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Monday, 22 August 2016

Isabelle Thome

Isabelle Thomé

Isabelle Thomé

Scientist Research and Development, Hoffmann La Roche




process research & development

 – Present (1 year 5 months)Basel Area, Switzerland

Postdoctoral Researcher with Prof. Phil S. Baran

The Scripps Research Institute
 –  (1 year 4 months)San Diego
C-H Imidation of (hetero)arenes and natural product synthesis
Studies toward the total synthesis of a sesquiterpene
(Open)1 honor or award

Doctoral Student with Prof. Carsten Bolm

RWTH Aachen University
 –  (5 years 6 months)RWTH Aachen
Development of new methods for the C-N bond formation
iron catalysis - cross couplings with parts-per-million quantities of copper - transition metal-free C-N bond formations

Interdoctoral Research with Prof. Bruce H. Lipshutz

UC Santa Barbara
 –  (4 months)Santa Barbara, California Area
Cross-couplings of alkyl with heteroaromatic halides, in water at room temperature
(Open)1 honor or award

Collaboration with Prof. Stephen L. Buchwald

Massachusetts Institute of Technology (MIT)
 –  (1 month)Cambridge, Massachusetts
On the role of metal contaminants in catalysis with FeCl3

Research Assistant

Karlsruhe Institute of Technology (KIT) / University of Karlsruhe (TH)
 –  (1 year)Institute of Nanotechnology, Karlsruhe


 –  (2 months)Ludwigshafen


Landes Lehr- und Versuchsanstalt
 –  (2 months)Trier

Honors & Awards

Feodor-Lynen Postdoctoral scholarship

Alexander von Humboldt

DAAD – German academic exchange service, scholarship



Karlsruher Institut für Technologie (KIT)

  • Chemical entrepreneurship


A Mild, Ferrocene-Catalyzed C–H Imidation of (Hetero)Arenes(Link)

Journal of the American Chemical Society
March 23, 2014
A simple method for direct C–H imidation is reported using a new perester-based self-immolating reagent and a base-metal catalyst. The succinimide products obtained can be easily deprotected in situ (if desired) to reveal the corresponding anilines directly. The scope of the reaction is broad, the conditions are extremely mild, and the reaction is tolerant of oxidizable and acid-labile...more

Catalytic, Asymmetric Synthesis of Phosphonic alpha-(Hydroxyalkyl)butenolides with Contiguous Quaternary and Tertiary Stereogenic Centers(Link)

Chemistry - A European Journal
January 8, 2014
A procedure that enables high yielding access to phosphonic γ-(hydroxyalkyl)butenolides with excellent regio-, diastereo- and enantiocontrol is reported. The simultaneous construction of up to two adjacent quaternary stereogenic centers by a catalytic asymmetric vinylogous Mukaiyama aldol reaction unites biologically and medicinally relevant entities, namely α-hydroxy phosphonates and γ-(...more

Transition-Metal-Free Intramolecular N-Arylations(Link)

Organic Letters
March 21, 2012
N-Substituted phenoxazines and related aza analogs have been prepared from N-acetylated aryloxy anilides by transition-metal-free, base-catalyzed cyclization reactions. In the presence of a mixture of 10 mol % of N,N′-dimethylethylenediamine (DMEDA) and 2 equiv of K2CO3 in toluene at 135 °C the products are obtained in high yields.

Base-Catalyzed Synthesis of Substituted Indazoles under Mild, Transition-Metal-Free Conditions(Link)

Angewandte Chemie
June 5, 2013
Back to basics: A transition-metal-free method developed for the synthesis of indazoles involves an inexpensive catalytic system composed of a diamine and K2CO3. Various (Z)-2-bromoacetophenone tosylhydrazones were converted into indazoles at room temperature in excellent yields (see example; Ts=p-toluenesulfonyl). The yield was improved by photoisomerization with UV light when E/Z isomeric...more

Trace metal impurities in catalysis(Link)

Chemical Society Reviews
January 4, 2012
Metal-catalysed transformations are a powerful tool in organic chemistry and the enormous progress, which has been made in the last few decades, was one more time honoured by the Nobel Prize in Chemistry in 2010. Many metal-containing compounds have been applied in carbon–carbon and carbon–heteroatom bond formations. However, not every component originally claimed as catalyst turned out to be the...more

Dimethyl Sulfoxide/Potassium Hydroxide: A Superbase for the Transition Metal-Free Preparation of Cross-Coupling Products(Link)

Advanced Synthesis and Catalysis
October 28, 2010
Potassium hydroxide (KOH) in dimethyl sulfoxide (DMSO) forms a superbasic medium that allows one to access cross-coupling products from reactions between aryl halides with various sulfur-, oxygen- and nitrogen-based nucleophiles under transition metal-free conditions.

Cross-couplings of alkyl halides with heteroaromatic halides, in water at room temperature(Link)

Tetrahedron Letters
April 27, 2011
Zn-mediated, Pd-catalyzed cross-coupling reactions between heteroaromatic and alkyl halides can be done at room temperature in pure water using a commercially available Pd catalyst and PTS, a nanomicelle-forming amphiphile. Notably, zinc metal inserts selectively into a carbon sp3-halide bond, while palladium adds oxidatively to a carbon sp2-bond.
4 authors

Synthesis of Chiral Sulfoximine-Based Thioureas and their Application in Asymmetric Organocatalysis(Link)

Beilstein Journal of Organic Chemistry
September 3, 2012
For the first time, chiral sulfoximine derivatives have been applied as asymmetric organocatalysts. In combination with a thiourea-type backbone the sulfonimidoyl moiety leads to organocatalysts showing good reactivity in the catalytic desymmetrization of a cyclic meso-anhydride and moderate enantioselectivity in the catalytic asymmetric Biginelli reaction. Straightforward synthetic routes provide...more

The Journal of Physical Chemistry B
October 5, 2010
Single-molecule microscopy is a powerful tool for investigating various uptake mechanisms of cell-penetrating biomolecules. A particularly interesting class of potential transporter molecules are peptoids. Fluorescence labels for such experiments need to comply with several physical, chemical, and biological requirements. Herein, we report the synthesis and photophysical investigation of new...more


Karlsruher Institut für Technologie (KIT)

Diplom, Chemistry

Diploma thesis at Karlsruhe Institute of Technology (KIT)
Institute of Nanotechnology, Organic Chemistry
with Prof. Dr. Stefan Bräse, KIT, Germany
“New functionalized chromophores”


  • Apr 2010–
    Aug 2010
    University of California, Santa Barbara
    Organic chemistry
    United States · Santa Barbara
  • May 2008–
    Oct 2013
    RWTH Aachen University
    Organic Chemistry · Dr. rer. nat.
    Germany · Aachen
  • Oct 2002–
    Jan 2008
    Karlsruhe Institute of Technology
    Chemistry · Diploma
    Germany · Karlsruhe

Awards & achievements

  • Jan 2014
    Scholarship: Feodor Lynen Postdoctoral Fellowship
  • May 2010
    Scholarship: DAAD short term scholarship


  • Languages
    English, French, German
  • Scientific Societies
    German Chemical Society
Isabelle Thome's Photo