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Friday, 13 February 2015

Prof Helen Hailes

Prof Helen Hailes
  • Professor of Chemical Biology
  • Dept of Chemistry
  • Faculty of Maths & Physical Sciences
Research Summary
Research activity in our group is focused on the use of synthetic organic chemistry to probe and solve biological problems. Current projects include the use of water as a reaction solvent and the use of catalytic and biocatalytic synthetic strategies. Also novel kinase inhibitors, cytosine-based hydrogen-bonding polymers and new lipid design for use in a ternary gene delivery vector.
Academic Background
1991PhDDoctor of Philosophy – Organic ChemistryUniversity of Cambridge
1987BABachelor of Arts – Chemistry and MetallurgyUniversity of Cambridge
publications..total 146
9 Research Activities
Prof Helen Hailes

Dr. Vasanth K Nalam

Dr. Vasanth K Nalam

DGM-R&D at Suven Life Sciences Ltd.
  1. Glenmark Research Centre
  2. Lupin Limited. (Research Park),
  3. Unichem Laboratories Ltd
  1. University of Mumbai


Nalam Vasanth Kumar


More than 20 years of rich experience in process research for API’s, new chemical entities (NCE’s), custom chemical synthesis (CCS) and contract research & manufacturing services (CRAMS) with reputed pharmaceutical organizations. Good understanding and analytical capabilities over various research areas (Medicinal chemistry & process research) and different business segments like APIs, CCS business.

Role and Responsibilities:

-New synthetic route identification.
-Development of non-infringing synthetic routes for Generic API’s and new chemical entities (NCE) with multiple-step chemistry and Scale-up varies therapeutic areas in a cost effective and environment friendly manner.
-Selection of cost effective suitable synthetic route for commercialization (Process research).
-Process optimization and process robustness demonstration from lab scale to commercial supplies (process development)
-Project leadership roles.
-Managing large team, team building, motivation and drive the team to achieve target.

Professional Experience:

-Complete project management includes heading a group of scientists working in various kind of projects (API, CCS)
-Providing sound technical proposals (chemistry selection, estimation of cost and timelines) & project plans for the custom synthesis and contract research for various clients.
-Responsible to meet the timeline for DMF filings as per business plan.
-Responsible for addressing the regulatory and business queries.
-Responsible for successful scale-up of technology at plant.
-Trouble shooting in Kilo lab/PP/Plant
-Identification of cost contributors and reduction of cost for better project margins and competitive advantage during the execution of projects.



Suven Life Sciences Ltd.
 – Present (6 years plus

Principal Scientist

Glenmark Research Centre
 –  (2 years)Mumbai

Research Scientist

Lupin Limited. (Research Park)
 –  (2 years 11 months)Pune

Group Leader

Unichem Laboratories Ltd
 –  (2 years 3 months)Pharmaceutical Company India - Unichem Laboratories Ltd.

Research Associate

Dr Reddys Labs
 –  (9 years 4 months)


University of Mumbai


Kakatiya University

M.Sc, Chemistry

Kakatiya University

Warangal Area, India

Kakatiya University

Research Publications
Ü Process Research and Development of Melatonin
    C. Prabhakar, N.Vasanth Kumar, M. Ravikanth Reddy, M.R. Sarma and G. Om Reddy.
    Organic Process Research & Development 1999, 3, 155-160
Ü Synthesis and Biological activity of novel Anti-bacterial Quinolones
M R Sarma, N Vasanth Kumar, A S R Prasad, S Eswaraiah, C Prabhakar, G Om Reddy, M Sitaram Kumar, A K Sadhukhan, A Venkateswarlu & K Anji Reddy. Indian Journal of Chemistry. Vol. 40B, 2001, 331-335
Ü Synthesis of some novel   ethyl 6-cyano-7-substituted-5-methyl-2-oxo-2H-pyrano [2, 3-b] pyridine-3-carboxylate derivatives. N Vasanth Kumar & Uday C Mashelker.  Indian J Chem. 45B, 2006, 1770.
Ü Diasteroselective synthesis of some novel Benzopyranopyridine derivatives.
Pradeep K Mohakhud, Sujeet Kumar, N Vasanth Kumar, V. Ravi Kumar, J. Moses Babu, K. Vyas and G Om Reddy, Beilstein Journal of Organic Chemistry 2006, 2:25  
Ü Synthesis of novel 1,2,4-oxadiazole heterocyclic compounds contain 2-H-pyranopyridine-2-one moiety and related compounds. N Vasanth Kumar & Uday C Mashelker.  Indian Journal of Chemistry, 46B, 2007, 216.
Ü Synthesis of novel 3-substituted derivatives of 2H-pyrano[2,3-b]pyridine-2-one moiety 
N Vasanth Kumar & Uday C Mashelkar. Journal of Indian Chemical Society, Vol. 84,October 2007, 1048-1051.
Ü Synthesis of new heterocyclic compounds containing 2H-pyrano-[2,3-b]pyridine-2-one moiety
N Vasanth Kumar & Uday C Mashelkar, Indian Journal of Heterocyclic Chemistry, Vol. 17, July-Sept., 2007, 99-100
Ü Synthesis of some novel 1,2,4-triazolo[4,3-a]-2H-pyrano[3,2-e] pyridine derivatives.
N Vasanth Kumar & Uday C Mashelkar,  Heterocyclic Communications, Vol. 13, No. 4, 2007, 211-214.

Patents & Patent Applications
Ü A novel method for the preparation of aryl piperazinyl heterocyclic compounds.
   Tyagi Om dutt; Srivastava Tushar kumar; Chauhan Yogendra Kumar; Nalam Vasanth Kumar WO
   2006/011157 A2.
Ü Preparation of [2-Methyl-5Phenyl-3-(Piperazin-1-yl Methyl)] Pyrrole Derivatives
     Arora Sudershan Kumar; Sinha Neelima; Jain Sanjay; Upadhayaya Ram Shankar; Tyagi Om Dutt; Nalam
    Vasanth; Chauhan Yogendra Kumar WO 2006/ 109323 A1.
Ü Preparation of (2-methyl-5-phenyl-3-(piperazin-1-ylmethyl)) pyrrole derivatives
    Nalam Vasanth; Chauhan yogendra Kumar; Upadhayaya Ram Shankar; Sinha Neelima; Jain Sanjay;
    Tyagi Om Dutt; Arora Sudershan Kumar AU2006233943

Ü Novel Method for the Preparation of Aryl Piperazinyl-Heterocyclic Compounds

    Tyagi Om D; Srivastava Tushar k ; Chauhan Yogendra K ; Nalam Vasanth K US2007238877
Ü Improved Process for the preparation of 7-amino-3-alkyl-3-cephem-4-carboxylic acid   compounds. Application 961/MUM/2004 published 2007-04-27, filed 2004-09-08
Ü A process for the preparation of novel crystalline form of Ziprasidone base.
    Application 1118/MUM/2004 published 2007-06-08, filed 2004-10-19
Ü A process for the preparation of novel crystalline form of Ziprasidone Hydrochloride Monohydrate Salt.
Application 1119/MUM/2004 published 2007-06-08, filed 2004-10-19.
Ü Improved Process for the manufacture of Ziprasidone.
     Tyagi Om D; Srivastava Tushar k ; Chauhan Yogendra K ; Nalam Vasanth K, Patil Sadanand Nilkanth.