DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair,With death on the horizon, This will not stop me, Gods call only..........
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contributio
n

Friday, 13 February 2015

DR ANTHONY MELVIN CRASTO, a worlddrugtracker

ANTHONY MELVIN CRASTO

DR ANTHONY MELVIN CRASTO Ph.D, worlddrugtracker

Email
MOBILE-+91 9323115463
GLENMARK SCIENTIST ,  INDIA


DR ANTHONY CRASTO, PhD, ICT Organic chemistry, Currently working with GLENMARK GENERICS LTD research centre as Principal Scientist, process research (bulk actives) at Mahape, Navi Mumbai, India, helping millions, million hits on google on all organic chemistry websites, Hands on experience in developing novel routes for drug molecules and implementation on commercial scale. several international patents published. 

Ph.D from ICT, Mumbai,ORG CHEM, Prof. S. SESHADRI, 25+ years in industry( API), mostly multinationals, process development in companies like Hoechst Marion Roussel(Sanofi aventis), Searle, RPG, Innovassynth, Glenmark, with exposure to basic research at SEARLE under Dr Nagarajan (Director Ciba), Tech transfer in plant eg deltamethrin 3 tonnes in RPG, bulk drug gmp (only 7 months) in Hoechst Marion Roussel(SANOFI AVENTIS), Custom syn in Innovasynth(SANDOZ, Basel, BASF Germany), exposure to natural pdts, drugs int, vet drugs, and some exposure in agro.speciality chemicals, flavours and fragrances, nutraceuticals and mettalocenes. ability to deliver products in the production plant(atleast 35 in career).
  • DR ANTHONY MELVIN CRASTO Ph.D Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google NO ADVERTISEMENTS , ACADEMIC , NON COMMERCIAL SITEs, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution


DR ANTHONY MELVIN CRASTO Ph.D , Born in Mumbai in 1964 and graduated from Mumbai University, Completed his  PhD from ICT ,1991,  Mumbai, India in Organic chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with GLENMARK- GENERICS LTD, Research centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Prior to joining Glenmark, he worked with major multinationals like Hoechst Marion Roussel, now Sanofi Aventis,  & Searle India ltd, now Rpg lifesciences, etc. He has worked in Basic research, Neutraceuticals, Natural products, Flavors, Fragrances, Pheromones, Vet Drugs, Drugs, formulation, GMP etc. He has total 25 yrs exp in this field, he is now helping millions, has million hits on google on all organic chemistry websites.His New Drug Approvals ,  Green Chemistry International,  Eurekamoments in Organic Chemistry ,   WIX BLOG WORLD DRUG TRACKER
are some most read chemistry blogsHe has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 25 year tenure, good knowledge of IPM, GMP, Regulatory aspects, he has  several international drug patents published worldwide .
He suffered a paralytic stroke in dec 2007 and is bound to a wheelchair, this seems to have injected feul in him to help chemists around the world, he is more active than before and is pushing boundaries, he has one lakh connections on all networking sites, He makes himself available to all, contact him on  +91 9323115463, amcrasto@gmail.com


Education

INSTITUTE OF CHEMICAL TECHNOLOGY (UDCT now ICT)Image result for ict mumbai







Ph.D., ORGANIC CHEM.
THESIS synthesis of novel pyrethroid analogues, 

Ph.D Programme, ICT, Formerly University Department of Chemical Technology, Matunga, Mumbai, India

The facade of the main building of the Institute








R.J.college, Ghatkopar, Bombay (University of Bombay)

M.Sc., Organic Chemistry 1986



                
Web link
アンソニー     安东尼   Энтони    안토니     أنتوني


Experience







Principal Scientist, Process research

Glenmark Generics Ltd.

 – Present, Mahape, Navimumbai, India,
Currently working with GLENMARK GENERICS LTD research centre as Principal Scientist, process research (bulk actives) at Mahape ,Navi Mumbai,and leading a team of scientists in developing APIs for regulated markets, this involves visualization and execution of novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis in lab and commercialization on plant , support for DMF filing.
Currently, involved in development of several targets for regulated markets. Provide support to US/European marketing team for developing and execution of new projects
Process Development :-
• Providing guidance and support for process development for challenging of patents in regulated market.
• Design patent non-infringing scalable synthetic routes/process and scale-up of API’s
• Bench and Pilot scale synthesis transformations in hands on
• Optimization of the process, ie,developing industrially feasible process.
• Preparation of PDR, filing of patent and DMF
• Lead a group of Scientists and Group Leaders(for docs).
Skill sets:- Technical skills:
Synthesis:
• Development of novel synthetic routes/process for pharmaceuticals and successful implementation of the technology in pilot plant
• Conducted various reactions at laboratory and production scales.
• Synthesized various classes of compounds.
• Experienced to work under cGMP condition
Documentation:
• Literature survey: well conversant with the use of Sci Finder and Internet search techniques.
• Operating Instruction: Preparation of scale up report (process, yield, costing, quality, specification etc.).
• Setting of specifications: Supported analytical section for method development and establishment of specification for Raw Material, Intermediate and finished products.
Soft skills:-
• Creativity in problem solving, Highly motivated and Self-starting individual, Excellent communication skill,Team leader with good listening

Glenmark | EUREKAMOMENTS IN ORGANIC CHEMISTRY by DR ANTHONY MELVIN CRASTO Ph.D
GLENMARK SCIENTISTS
SICC SINGAPORE | EUREKAMOMENTS IN ORGANIC CHEMISTRY by DR ANTHONY MELVIN CRASTO Ph.D
SICC SINGAPORE2005 oct






Principal scientist, GLENMARK PHARMACEUTICALS LTD research centre

Glenmark Pharmaceuticals

 –  (1 year 7 months)MAHAPE, INDIA, email me, amcrasto@gmail.com, 09323115463, call now
RESEARCH ACTIVITIES COVERED IN THE ENTIRE CAREER
1) Extensive range of chemistry and scale of manufacture from laboratory, scale up laboratory, pilot plant, plant scale including third party activity.

Applied intellectual and synthetic skills to the process development of pharmaceutical drugs/their intermediates, and natural products, neutraceuticals, mettalocenes, speciality chemicals, flavours and fragrances in the laboratory and monitor them during plant trials.

Act as a technology transfer man and provide all data required for transfer from lab to commercialization.

Use of Internet and manual literature search methods to decide on non infringing route

Write DHR for API before implementation of novel route in the plant and assist for all batches for the DMF purposes, very well versed with IPR issues

Ability to develop novel routes for API,s and draft patents,well versed with polymorphism issues.several patents filed in US/EU
total exp23+ in industry, Currently working as principal scientist and leading a team of scientists in developing APIs for regulated markets, this involves novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis and commercialization and assist in providing support for DMF filing.
Currently involved in development of several targets for regulated markets. The job involves visualization of novel routes and its execution , simultaneously develop intellectual property and generate data in the process,. Provide support to US/European marketing team for developing and execution of new projects











Sr Manager R&D or Group principal scientist

Innovassynth

 –  (2 years 7 months)KHOPOLI, MH, INDIA, Led a team of 30 chemists for the custom synthesis business in the area of drugs, organic intermediates, speciality chemicals, flavours and fragrances, nutraceuticals and mettalocenes. (25 projects) This included rapid development, scale up and commercialization as per the needs of the foreign clients with a time frame.customers were Sandoz Basel, BASF Germany, 
INNOVA | EUREKAMOMENTS IN ORGANIC CHEMISTRY by DR ANTHONY MELVIN CRASTO Ph.D
INNOVA 








Manager, research and development, API,RPG Life sciences ltd (formerly American multinational SEARLE

RPG Life Sciencess

 –  (5 years 8 months)PAWNE, MH, INDIA, 

1 Donepezil : Manufactured 4 kilos on pilot plant scale as R & D demonstration, the process was developed from scratch. Plans are to make 25 kilos with 300% profit margins


2) Pantoprazole : Process is being modified continuously to cope-up with price crash
3) PZL Chloride an intermediate of Pantoprazole : Multi step process is being continuously modified / developed to meet cost demands
4) Manufactured 3 tonnes deltamethrin on plant scale as R & D demonstration at an commercially viable cost, the process was developed from scratch ie lit,lab work, scale-up, pilot trials and also included third party work for one bromination step,which needed 8 reactors. Later on annually about 25 tonnes were manufactured. later on the company was taken over by a multinational for deltamethrin. the price in market crashed to half.
5) Acetamiprid : Developed a process from scratch. Process was handed over to isagro for commercialization in 2001 during hiving of the company from RPG
6) M-alcohol an intermediate of Tetra conazole : During isagro transition period in 2001, the process from Italy was adapted to Indian plant conditions, scaled up with some modification and handed over for commercialization. This is being produced on a regular basis.
7) Pyrazosulfuron ethyl : Developed a process from scratch. Process was handed over to isagro for commercialization in 2001 during hiving of the company from RPG
MANY PROJECTS ON CUSTOM SYNTHESIS FOR CBZ, PFIZER, AVENTIS, ETC WERE DONE DURING THIS TENURE IN RPG LIFE SCIENCES

LONDON | EUREKAMOMENTS IN ORGANIC CHEMISTRY by DR ANTHONY MELVIN CRASTO Ph.D
LONDON 2000 SEPT







Manager, R &D-sister concern of RPG--1 MONTH, ISAGRO INDIA PVT LTD-- AN ITALIAN MULTINATIONAL


 Isagro S.p.A


  –  (2 months) 

Carried out Synthetic Research work partly at (R&D) at RPG RESEARCH CENTRE NAVIMUMBAI- PLANT WAS AT PANOLI, GUJARAT, INDIA









7 MONTHS ONLY WITH GMP/QA DEPT AND REPORTING TO GMP HEAD , ASIA PACIFIC

HOECHST MARION ROUSSEL
A –  (7 months)MULUND, INDIA,
QUALITY ASSURANCE/GOOD MANUFACTURING PRACTICES

1. Exposure to GMP in Bulk drugs and Formulations

2. Excellent Computer literacy.

3 Prepared Drug master files and Site master files for submission to Foreign
and Local regulatory bodies.

4. Conducted Process validations of Bulk drugs.

5. Exposure to cleaning validations.

6. Reviewing of SOP's for different departments.

7. Reviewing of MFR's and BMR's

8. All aspects of documentation with respect to GMP guidelines.

9. Involved in a successful preparation for an audit by the Australian
regulatory body." Therapeutic Goods Administration (TGA) "

10. Similar involvement with a WHO audit of formulations

11. Conducted several GMP audits.

12 Conducted several Vendor assessments.


MANUFACTURING
Practical Production training in Pharmaceutical manufacturing in the following Departments.
1. Powder injectibles

2. Large Volume Parenterals (Haemaccel)

3. Small Volume Parenterals (Liquid injectibles)

4. Tablets.






Executive BULK DRUG QA for short time at German multinational Hoechst Marion Roussel Ltd 

HOECHST INDIA LIMITED

A –  (7 months)
VISITED TABLETS, LARGE VOLUME PARENTERALS, INJ, STORES ETC AS PART OF GMP TRAINING









CUSTOM SYNTHESIS

BASF

M –  (3 months)
CUSTOM SYNTHESIS OF API, Eg COENZYME Q10, ETC







PROJECTS HANDLED IN CUSTOM SYN AREA

Sandoz

M –  (3 months)
MANY PROJECTS ON CUSTOM SYNTHESIS FOR CBZ, PFIZER, AVENTIS, ETC WERE DONE DURING THIS TENURE IN INNOVASSYNTH








Executive process development for short timeHOECHST SCHERING AGREVO a sister concern of HMR,

HOECHST SCHERING AGREVO

F –  (4 months)
PROCESS DEVELOPMENT OF AGROCHEMICALS FOR VERY SHORT TIME SINCE THIS COMPANY WAS A SISTER CONCERN OF HOECHST MARION ROUSSEL AND REPORTED TO DR RALPH STAPEL,DIRECTOR PROCESS DEVELOPMENT(ANILOPHOS, DELTAMETHRIN, TEFURAMETHRIN)











Exec proc.development pharmaceuticals, Hoechst Marion Roussel, now Sanofi Aventis

Sanofi-aventis

J –  (4 years 1 month)
MULUND, Mumbai. INDIA The job involved all aspects of synthesis and commercialization from research lab to production,
PROJECTS HANDLED:
1.Pentoxyfylline : Independently developed a new route

2.Roxatidine : In a team worked on some of its intermediates; Process development and production trouble Shooting

4.ECPPA : Independently developed a 5 step route for the
synthesis of this single isomer (Enalapril/Ramipri
Intermediate)

5.Furamethrin Alc : Independently developed a commercially viable route for its manufacture involving Acetylene as the raw material.

6.Tefuramethrin : Independently developed its synthesis for M/S
Diannihon Jochugiko Japan.

7. Several Drugs/ Vet.Drugs : Trouble shooting for production (eg. PitofenoneHCl, Frusemide, Ramipril, etc.)
HOECHST | EUREKAMOMENTS IN ORGANIC CHEMISTRY by DR ANTHONY MELVIN CRASTO Ph.D
HOECHST
RALPH STAPEL
DR RALPH STAPEL, TECH DIRECTOR
HOECHST

https://lh5.googleusercontent.com/-a-CsWwXtn_w/R0reXVENlQI/AAAAAAAABbE/28fJyVWuEwc/s500/1414893317_9f6478b4c4%255B1%255D.jpg


Photohoechst lab






PROJECTS HANDLED as Management Trainee Research and devl. SEARLE INDIA LTD

Searle

 –  (1 year 8 months)PAWNE, INDIA
1 year 7 months)
(Drugs and Natural products )

1) Azathioprine :worked on all the steps. ALSO WORKED ON CANNABINOID DRUGS, OLIVETOL, worked on menthadienol, iohexol, x ray contrast agents,







ORGANIC process development, INDIAN ORGANIC CHEMICALS, KHOPOLI, INDIA

INDIAN ORGANIC CHEMICALS

J –  (4 years 4 months)
ID ORGANIC PROCESS DEVELOPMDENT AS A RESEARCH FELLOW, 









Ph. D research fellow, Organic chemistry

Institute Of Chemical Technology

 –  (4 years 4 months)MATUNGA, MUMBAI, INDIA,
4years
Worked as Indian Organic; PhD programme(organic chemistry) on the topic " Synthesis of novel pyrethroids analogues". Simultaneously did project work for IOC.




blogs are 
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you can post articles and will be administered by me on the google group which is very popular across the world
WORLD DRUG TRACKER FACEBOOK



Certifications





DIPLOMA IN INDUSTRIAL AND ANALYTICAL CHEMISTRY

CIPLA RUIA TDM LAB





GENERAL ELECTRONICS

BOMBAY INSTITUTE OF TECHNOLOGY






DIPLOMA IN BUSINESS MANAGEMENT

WELINGKAR INSTITUTE, PODAR COLLEGE, MUMBAI



COMPUTER PROGRAMMING, MULUND, MUMBAI






MILLION HITS ON GOOGLE, HELPING MILLIONS

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Patents




Process for the preparation of atovaquone

United States US20090105350

Issued October 9, 2008
Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN







Process for the preparation of tadalafil

Europe WO 2007110734
Issued 
Process for the preparation of tadalafil, ep also EP2004644
Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN
Process for the preparation of tadalafil
PCT Application WO2007110734 | Filed: 03/23/2007 |...







Amorphous eprosartan mesylate and process for the preparation thereof

United States US20080014263

Issued
Amorphous eprosartan mesylate and process for the preparation thereof
Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN







Method for preparation of dronedarone via palladium-catalyzed hydrogenation and methanesulfonylation

Europe WO 2012007959

Issued January 2012
Method for preparation of dronedarone via palladium-catalyzed hydrogenation and methanesulfonylation WO 2012007959
Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN







Method for preparation of 2, 3-diaryl-5-substituted pyridines and their intermediates

Europe WO 2011158250

Issued December 22, 2011
Method for preparation of 2, 3-diaryl-5-substituted pyridines and their intermediates ETORICOXIB
Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN







Amorphous eprosartan mesylate and process for the preparation thereof

United States US 20080014263

Issued January 17, 2008
Amorphous eprosartan mesylate and process for the preparation thereof






AMORPHOUS BAZEDOXIFENE ACETATE AND PREPARATION THEREOF

United States US 20100310870

Issued
US 20100310870, AMORPHOUS BAZEDOXIFENE ACETATE AND PREPARATION THEREOF







A PROCESS OF PREPARATION OF METHANAMINE-N-[4(3,4-DICHLOROPHENY)-3,4-DIHYDRO-1(2H)-NAPHTHALENYLIDENE

India INDIAN PAT Ref. No: Appl No.243/BOM/1999 A, Year: 01/1999

Issued January 1, 1999
A PROCESS OF PREPARATION OF METHANAMINE-N-[4(3,4-DICHLOROPHENY)-3,4-DIHYDRO-1(2H)-NAPHTHALENYLIDENE
Ref. No: Application No.243/BOM/1999 A, Year: 01/1999







IMPROVED PROCESS FOR THE PREPARATION OF TADALAFIL

India INDIN PAT Ref. No: 1135/MUM/2006

Issued July 18, 2008
Ref. No: 1135/MUM/2006 - Published: 2008-07-18 - GLENMARK PHARMACEUTICALS LIMITED, Year: 07/2008







A PROCESS FOR THE PREPARATION OF ATOVAQUONE CRYSTALLINE

India Ref. No: 1742/MUM/2007 A, Year: 01/2009

Issued January 1, 2009
Ref. No: 1742/MUM/2007 A, Year: 01/2009

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Inaugural ACS Industry Symposium, 11-12 November 2016 in Hyderabad, India

Recent Advances in Drug Development

Register Today for the ACS Symposium in India on Recent Advances in Drug Development
To view this email as a web page, go here.
Register now for the inaugural ACS Industry Symposium, 11-12 November 2016 in Hyderabad, India. Be sure to secure your seat today as rates will increase on 27 October!
http://acssymposium.org.in/
The theme of the Symposium is Recent Advances in Drug Development. The event will feature lectures by the world's leading researchers and experts in the pharma industry, including:
  • Dr. Peter Senter of Seattle Genetics
  • Dr. Jagath Reddy Junutula of Cellerant Therapeutics, Inc.
  • Dr. Ming-Wei Wang of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences
This is an exclusive event being organized in partnership with Dr. Reddy's Laboratories for pharma professionals throughout India. Space is limited so register today!
Please visit our website to learn more about the speakers and the program.
Register today to ensure your access to the ACS Industry Symposium. We look forward to seeing you in Hyderabad in November.
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Inaugural ACS Industry Symposium, 11-12 November 2016 in Hyderabad, India Recent Advances in Drug Development

//////////////

                    

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ANTHONY MELVIN CRASTOI was  paralysed in dec2007, Posts dedicated to my family, my organisation Glenmark, Your readership keeps me going and brings smiles to my family







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