Simi Gunaseelan, Ph.D.
Assistant Professor of Pharmaceutical Sciences, The University of Texas at Tyler, TEXAS, USA
links
Title: Assistant Professor of Pharmaceutical Sciences
Department: Pharmaceutical Sciences - Pharmacy
Building: WTB 346
Email: sgunaseelan@uttyler.edu
Phone: 903.565.5783
Department: Pharmaceutical Sciences - Pharmacy
Building: WTB 346
Email: sgunaseelan@uttyler.edu
Phone: 903.565.5783
Experience
Assistant Professor of Pharmaceutical Sciences, The University of Texas at Tyler College of Pharmacy
Assistant Professor of Pharmaceutical Sciences, The University of Texas at Tyler, Tyler, TEXAS, USA
A. Responsibilities / Committee Appointments as ‘Founding Faculty’ at University of Texas at Tyler, Ben and Maytee Fisch College of Pharmacy, Tyler, Texas, USA (2014-Present):
• Curricular Development (Team-Based Learning Course Content, Curricular Sequencing & Integration), Curricular Mapping (2016 Standards, Appendix B, Cape Outcomes, etc.) and Programmatic & Curricular Assessment Plans
• Chair, Assessment Committee
• Member, Library Advisory Committee at University Level
B. Teaching Responsibilities at University of Texas at Tyler, Ben and Maytee Fisch College of Pharmacy, Tyler, Texas, USA (2014-Present):
• Pharmaceutical Calculations
• Pharmaceutics (Physical Pharmacy and Dosage Forms)
• Compounding Lab
• Biopharmaceutics and Advanced Drug Delivery Systems
• Elective Courses on Introduction to Nuclear Pharmacy and Advanced Drug Delivery Systems
C. Scholarly Work at University of Texas at Tyler, Ben and Maytee Fisch College of Pharmacy, Tyler, Texas, USA (2014-Present):
• Scientific research on HIV Prevention
• Development of Drug Formulations
• Pharmacy Educational Research
This scholarly work led to 2 publications in peer-reviewed journals.
• Curricular Development (Team-Based Learning Course Content, Curricular Sequencing & Integration), Curricular Mapping (2016 Standards, Appendix B, Cape Outcomes, etc.) and Programmatic & Curricular Assessment Plans
• Chair, Assessment Committee
• Member, Library Advisory Committee at University Level
B. Teaching Responsibilities at University of Texas at Tyler, Ben and Maytee Fisch College of Pharmacy, Tyler, Texas, USA (2014-Present):
• Pharmaceutical Calculations
• Pharmaceutics (Physical Pharmacy and Dosage Forms)
• Compounding Lab
• Biopharmaceutics and Advanced Drug Delivery Systems
• Elective Courses on Introduction to Nuclear Pharmacy and Advanced Drug Delivery Systems
C. Scholarly Work at University of Texas at Tyler, Ben and Maytee Fisch College of Pharmacy, Tyler, Texas, USA (2014-Present):
• Scientific research on HIV Prevention
• Development of Drug Formulations
• Pharmacy Educational Research
This scholarly work led to 2 publications in peer-reviewed journals.
- (Open)2 honors and awards
Assistant Professor of Pharmaceutical Sciences, West Coast University School of Pharmacy
Assistant Professor of Pharmaceutical Sciences, West Coast University, Los Angeles, CALIFORNIA, USA
A. Responsibilities / Committee Appointments as ‘Founding Faculty’ at West Coast University, School of Pharmacy, Los Angeles, California, USA (2012 – 2014):
• Development of School’s Vision, Mission, Values, Long & Short-term Strategic Planning of Goals, Curricular Philosophy, Programmatic Learning Outcomes, Curricular Development (Course Content, Course Credit Allocation, Curricular Sequencing & Integration), Curricular Mapping (Appendix B, Cape Outcomes, etc.) and Programmatic & Curricular Assessment Plans
• Accreditation Council for Pharmacy Education (ACPE) Application Preparation for Pre-Candidate Status
• Chair, Writing ACPE Curriculum Standards 9-15
• Chair, Admissions Committee
• Member, Faculty Search Committee
• Member, Bylaws Committee
• Member, Assessment Committee
• Member, Academic Standing Committee
B. Teaching Responsibilities at West Coast University, School of Pharmacy, Los Angeles, California, USA (2012 – 2014):
• Pharmaceutical Calculations
• Pharmaceutics I (Physical Pharmacy and Dosage Forms)
• Compounding Lab
• Pharmaceutics II (Biopharmaceutics and Advanced Drug Delivery Systems)
• Contemporary Biotechnology
• Medicinal Chemistry
• Elective Courses on Introduction to Nuclear Pharmacy and Clinical Toxicology
C. Teaching Responsibilities at West Coast University, College of Nursing, California, USA (2012 – 2014):
• Biochemistry, Fall Term 2013 (North Hollywood Campus, 40 hours of teaching) & Winter Term 2013 (Ontario Campus, 24 hours of teaching) (Total of 64 hours of teaching to nursing students).
D. Scholarly Work at West Coast University, School of Pharmacy, California, USA (2012 – 2014):
• Pharmacy curricular development
• Global trends in introducing clinical and patient-centered pharmaceutical care aspects of pharmacy education in the pharmacy curriculum.
• Review of cardiovascular effects on natural products.
This scholarly work led to 3 publications in peer-reviewed journals.
• Development of School’s Vision, Mission, Values, Long & Short-term Strategic Planning of Goals, Curricular Philosophy, Programmatic Learning Outcomes, Curricular Development (Course Content, Course Credit Allocation, Curricular Sequencing & Integration), Curricular Mapping (Appendix B, Cape Outcomes, etc.) and Programmatic & Curricular Assessment Plans
• Accreditation Council for Pharmacy Education (ACPE) Application Preparation for Pre-Candidate Status
• Chair, Writing ACPE Curriculum Standards 9-15
• Chair, Admissions Committee
• Member, Faculty Search Committee
• Member, Bylaws Committee
• Member, Assessment Committee
• Member, Academic Standing Committee
B. Teaching Responsibilities at West Coast University, School of Pharmacy, Los Angeles, California, USA (2012 – 2014):
• Pharmaceutical Calculations
• Pharmaceutics I (Physical Pharmacy and Dosage Forms)
• Compounding Lab
• Pharmaceutics II (Biopharmaceutics and Advanced Drug Delivery Systems)
• Contemporary Biotechnology
• Medicinal Chemistry
• Elective Courses on Introduction to Nuclear Pharmacy and Clinical Toxicology
C. Teaching Responsibilities at West Coast University, College of Nursing, California, USA (2012 – 2014):
• Biochemistry, Fall Term 2013 (North Hollywood Campus, 40 hours of teaching) & Winter Term 2013 (Ontario Campus, 24 hours of teaching) (Total of 64 hours of teaching to nursing students).
D. Scholarly Work at West Coast University, School of Pharmacy, California, USA (2012 – 2014):
• Pharmacy curricular development
• Global trends in introducing clinical and patient-centered pharmaceutical care aspects of pharmacy education in the pharmacy curriculum.
• Review of cardiovascular effects on natural products.
This scholarly work led to 3 publications in peer-reviewed journals.
Degrees
- 2002
Doctor of Philosophy, Ph.D. (Physical Organic Chemistry), Dept. of Chemistry, North-Eastern Hill University, Shillong, India.
- 1996
Master of Science, M.Sc.(Organic Chemistry), Dept. of Chemistry, North-Eastern Hill University, Shillong, India.
- 1994
Bachelor of Science, B.Sc.(Chemistry), North-Eastern Hill University, Shillong, India
Education
Loma Linda University School of Pharmacy, Dept. of Pharmaceutical Sciences, CALIFORNIA, USA
Subliming Solid-Based Intravaginal Microbicide Delivery Technology for HIV Prevention
A. Research Work at Loma Linda University, School of Pharmacy, California, USA (Collaboration with Scripps Research Institute, California and University of Pittsburgh, Pennsylvania) (2010 – 2012):
Research included the development of ‘Universal Subliming Solid-based Drug Delivery Systems’ for achieving steady-state durations of intravaginal HIV microbicide delivery ranging from weeks to several months.
This research work led to 2 publications in highly reputed journals.
B. Teaching Responsibilities at Loma Linda University, School of Pharmacy, California, USA (2010 – 2012):
• Pharmaceutics II (Physical Pharmacy), PY1, Winter Quarter 2012
Research included the development of ‘Universal Subliming Solid-based Drug Delivery Systems’ for achieving steady-state durations of intravaginal HIV microbicide delivery ranging from weeks to several months.
This research work led to 2 publications in highly reputed journals.
B. Teaching Responsibilities at Loma Linda University, School of Pharmacy, California, USA (2010 – 2012):
• Pharmaceutics II (Physical Pharmacy), PY1, Winter Quarter 2012
Rutgers University School of Pharmacy, Dept. of Pharmaceutical Sciences, NEW JERSEY, USA
Polymer-Based Drug Delivery Technology for Cancer and HIV Therapeutics
Research Work at Rutgers University, School of Pharmacy, New Jersey, USA (2002 – 2010): Research included the development of an anti-cancer drug delivery system using novel hydrogel formulation for cancer therapy by releasing drug or modified version of that drug (nanocarriers using PEGs/polymers, peptidic carriers and targeting agents) at a relatively constant rate for a period ranging from days to weeks. Research also included the development of an anti-HIV drug delivery system using novel prodrugs/nanocarriers of HIV protease inhibitors and peptides and peptide mimetics involving PEGs/polymers, peptidic carriers and targeting agents with a potential for development into new types of AIDS therapeutics.
This research work led to 3 ‘Issued’ United States Patents, 2 United States Patent Applications and 8 publications in highly reputed journals.
This research work led to 3 ‘Issued’ United States Patents, 2 United States Patent Applications and 8 publications in highly reputed journals.
North-Eastern Hill University, Dept. of Chemistry, Shillong, INDIA
Doctor of Philosophy (Ph.D.), Physical Organic Chemistry
PhD Research Work at North-Eastern Hill University, Dept. of Chemistry, Shillong, India (1997 – 2002):
• Oxidation of different types of aldehydes, ketones and acids using inorganic oxidizing agent, quinolinium dichromate (QDC). Chemical characterization of oxidized products.
• Kinetics and Mechanism of Oxidation Reactions – Extensive kinetic studies on oxidation reactions of aldehydes, ketones and acids spectrophotometrically. Evaluating mechanistic pathway of these oxidation reactions based on their kinetic profile.
This research work led to 10 publications in journals of repute.
• Oxidation of different types of aldehydes, ketones and acids using inorganic oxidizing agent, quinolinium dichromate (QDC). Chemical characterization of oxidized products.
• Kinetics and Mechanism of Oxidation Reactions – Extensive kinetic studies on oxidation reactions of aldehydes, ketones and acids spectrophotometrically. Evaluating mechanistic pathway of these oxidation reactions based on their kinetic profile.
This research work led to 10 publications in journals of repute.
Summary
Dr. Gunaseelan is currently an Assistant Professor at the University of Texas at Tyler College of Pharmacy for the past 2 years. She moved from West Coast University School of Pharmacy, California where she served as an Assistant Professor for 2 years. She possesses 8 extensive years of research experience from Rutgers University School of Pharmacy, New Jersey. She also gained 2 years of research and teaching experience from Loma Linda University School of Pharmacy, California. For the past 14 years she has been working on `Novel Drug Delivery Systems' for HIV Prevention & HIV and Cancer Therapeutics. At Rutgers University, New Jersey, she worked on NIH RO1 grant projects where her main focus was on `Polymer-Based Drug Delivery Technology for HIV & Cancer Therapeutics' while at Loma Linda University, California, she worked on NIH RO1 grant project specific to `Subliming Solid-Based Intravaginal Microbicide Delivery Technology for HIV Prevention'. Her research work resulted in 5 patents, 25 publications in high-impact journals and 27 presentations at national and international level. Her dedication towards research work at Rutgers University, New Jersey, led her to be a recipient of Merit Award for 3 consecutive years. She has been honored with a 'Certificate of Recognition' for her research presentation (podium) on "Novel Intravaginal Delivery of Antiretroviral-based Microbicides for HIV Prevention" at the 2015 World Drug Delivery Summit, Houston where she was an Invited Speaker. She received the 2016-2017 University of Texas at Tyler Research Award for her research "Elimination of Bitterness in Pediatric Oral Suspension using Novel Formulation". She is currently a reviewer for Advanced Drug Delivery Reviews, Pharmaceutical Research and Controlled Release Society Meetings.
http://www.uttyler.edu/directory/pharmacy-pharmaceuticalsciences/gunaseelan.php
http://drugdelivery.pharmaceuticalconferences.com/speaker/2015/simi-gunaseelan-university-of-texas-usa
http://www.uttyler.edu/directory/pharmacy-pharmaceuticalsciences/gunaseelan.php
http://drugdelivery.pharmaceuticalconferences.com/speaker/2015/simi-gunaseelan-university-of-texas-usa
Teaching Appointments
2014 – Present
Founding Faculty (Assistant Professor), Dept. of Pharmaceutical Sciences, Ben and Maytee Fisch College of Pharmacy, The University of Texas at Tyler, Texas, USA.
2014 – Present
Founding Faculty (Assistant Professor), Dept. of Pharmaceutical Sciences, Ben and Maytee Fisch College of Pharmacy, The University of Texas at Tyler, Texas, USA.
2012 – 2014
Founding Faculty (Assistant Professor), Dept. of Pharmaceutical Sciences, School of Pharmacy, West Coast University, California, USA.
Founding Faculty (Assistant Professor), Dept. of Pharmaceutical Sciences, School of Pharmacy, West Coast University, California, USA.
2010 -2012
Senior Research Associate (NIH project - “Subliming Solid - Based Intravaginal Microbicide Delivery Technology for HIV Prevention”), Dept. of Pharmaceutical Sciences, School of Pharmacy, Loma Linda University, California, USA.
Senior Research Associate (NIH project - “Subliming Solid - Based Intravaginal Microbicide Delivery Technology for HIV Prevention”), Dept. of Pharmaceutical Sciences, School of Pharmacy, Loma Linda University, California, USA.
2002 - 2009
Postdoctoral Associate, Research Associate, Senior Research Associate(NIH projects-“Polymer-Based Drug Delivery Technology for Cancer& AIDS Therapeutics”), Dept. of Pharmaceutical Sciences, School of Pharmacy, Rutgers University, New Jersey, USA.
Complete Curriculum Vitae
Postdoctoral Associate, Research Associate, Senior Research Associate(NIH projects-“Polymer-Based Drug Delivery Technology for Cancer& AIDS Therapeutics”), Dept. of Pharmaceutical Sciences, School of Pharmacy, Rutgers University, New Jersey, USA.
Complete Curriculum Vitae
Simi Gunaseelan
University of Texas, USA.Title: Novel Intravaginal Delivery of Antiretroviral-based Microbicides for HIV prevention
Biography
Gunaseelan’s research expertise is in drug delivery. For the past 10 years she has been working towards developing ‘Novel Drug Delivery Systems’ for HIV Prevention & HIV and Cancer Therapeutics. Her research works resulted in 5 patents, more than 20 publications in high-impact journals and presentations in 20 national and international conferences. Her dedication towards research work at Rutgers University School of Pharmacy New Jersey, led her to be a recipient of Merit Award for 3 consecutive years. She is currently a journal reviewer for Advanced Drug Delivery Reviews, Pharmaceutical Research, and Controlled Release Society Meeting AbstractsAbstract
Objectives: Microbicides, products applied vaginally or rectally, are effective at preventing HIV transmission. However, many products (e.g., peptides, antiretroviral drugs) are reactive or incompatible in the existing diffusion/hydrolysis/dissolution based delivery systems. To overcome the issues of extended delivery and product compatibility, the use of a novel subliming solid matrix-based delivery system is described here. Methods: The microbicides C5A, tenofovir fumarate, emtricitabine, dapivarine, UC-781 and IQP0528 were employed as representatives of a range of molecular structures and physicochemical properties. Hydrophobic, chemically inert subliming solid matrices, utilized for microbicide formulations and achieving a defined range of sustained release rates, included norbornane, hexamethylcyclotrisiloxane, perfluoroundecane, perfluorododecane and cyclododecane. Rates of matrix sublimation and concomitant microbicide release were determined in vitro. Formulations were tested for cellular toxicity, and durations of anti-HIV-1 activity by constant release of microbicides from the sublimable matrices. Results: Subliming solid matrices release microbicides by surface erosion achieved through sublimation. Zero order sustained microbicide release was achieved in vitro, at rates independent of microbicide structures and properties, and controlled exclusively by sublimation enthalpies of each hydrophobic matrix material. The matrices provided prolongation of anti-HIV-1 activity relative to bolus microbicide administration, when evaluated in cultured human ectocervical tissue, macrophages, and TZM reporter cells. No evidence of matrix toxicity was observed after continuous exposure to macrophages, T-lymphocytes, PBMC cells and ectocervical explants. Implications: Subliming matrices offer unique attributes that will allow steady-state delivery of any microbicide, over durations ranging from weeks to months, by employing, simple, stable, and readily available matrix materials, suggesting novel delivery capabilities.
As a Faculty all geared up in my PhD gown to honor the University of Texas Students at the Phi Kappa Phi Honors Society_Tyler, Texas April 2016— at University of Texas at Tyler.
With my favorite Pharmacy Doctorate Students @ West Coast University, Los Angeles, California - November 2014
See ppt at
https://1drv.ms/p/s!AtJ9edelcTD8hFUEnjANw68ifsM- click to see ppt
Simi Gunaseelan
University of Texas, USA.Title: Novel Intravaginal Delivery of Antiretroviral-based Microbicides for HIV prevention
Biography
Gunaseelan’s research expertise is in drug delivery. For the past 10 years she has been working towards developing ‘Novel Drug Delivery Systems’ for HIV Prevention & HIV and Cancer Therapeutics. Her research works resulted in 5 patents, more than 20 publications in high-impact journals and presentations in 20 national and international conferences. Her dedication towards research work at Rutgers University School of Pharmacy New Jersey, led her to be a recipient of Merit Award for 3 consecutive years. She is currently a journal reviewer for Advanced Drug Delivery Reviews, Pharmaceutical Research, and Controlled Release Society Meeting AbstractsAbstract
Objectives: Microbicides, products applied vaginally or rectally, are effective at preventing HIV transmission. However, many products (e.g., peptides, antiretroviral drugs) are reactive or incompatible in the existing diffusion/hydrolysis/dissolution based delivery systems. To overcome the issues of extended delivery and product compatibility, the use of a novel subliming solid matrix-based delivery system is described here. Methods: The microbicides C5A, tenofovir fumarate, emtricitabine, dapivarine, UC-781 and IQP0528 were employed as representatives of a range of molecular structures and physicochemical properties. Hydrophobic, chemically inert subliming solid matrices, utilized for microbicide formulations and achieving a defined range of sustained release rates, included norbornane, hexamethylcyclotrisiloxane, perfluoroundecane, perfluorododecane and cyclododecane. Rates of matrix sublimation and concomitant microbicide release were determined in vitro. Formulations were tested for cellular toxicity, and durations of anti-HIV-1 activity by constant release of microbicides from the sublimable matrices. Results: Subliming solid matrices release microbicides by surface erosion achieved through sublimation. Zero order sustained microbicide release was achieved in vitro, at rates independent of microbicide structures and properties, and controlled exclusively by sublimation enthalpies of each hydrophobic matrix material. The matrices provided prolongation of anti-HIV-1 activity relative to bolus microbicide administration, when evaluated in cultured human ectocervical tissue, macrophages, and TZM reporter cells. No evidence of matrix toxicity was observed after continuous exposure to macrophages, T-lymphocytes, PBMC cells and ectocervical explants. Implications: Subliming matrices offer unique attributes that will allow steady-state delivery of any microbicide, over durations ranging from weeks to months, by employing, simple, stable, and readily available matrix materials, suggesting novel delivery capabilities.Speaker Presentations
Simi Gunaseelan
Presentations at the 2016 AACP (American Association of Colleges of Pharmacy) Meeting : A 5-Day Annual Pharmacy Conference_July 2016_Anaheim Convention Center, California — at Anaheim Convention Center.
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