Professor Anita Maguire
Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre,University College Cork, Cork, Ireland
Department of Chemistry
University College Cork
Cork, Ireland
Tel: +353-21-4902125
Cork, Ireland
Tel: +353-21-4902125
Tel. (secretary) +353-21-4902167
Fax. +353-(0)21-4274097 (Departmental Office)
E-mail: a.maguire@ucc.ie
University College Cork
Biography
Professor Anita Maguire commenced as Vice President for Research and Innovation in UCC in January 2011.
Anita undertook undergraduate and postgraduate studies in Chemistry at UCC (B.Sc. 1985, Ph.D. 1989). Following postdoctoral research first at Namur, Belgium then at the University of Exeter, UK she returned to the Department of Chemistry in UCC in 1991, initially as a College Lecturer, then Associate Professor in Organic Chemistry in 2002, and was appointed to the newly-established Chair of Pharmaceutical Chemistry in 2004, playing a leading role in development of the School of Pharmacy in recent years. Since her appointment at UCC she has played a strategic role in the development of teaching and learning, including the introduction of Medicinal and Pharmaceutical Chemistry at undergraduate level for the first time.
Over the past twenty years at UCC she has led an active research team focusing on synthetic organic and pharmaceutical chemistry, which interacts extensively with the pharmaceutical sector in Ireland and internationally. She is very committed to postgraduate education, ensuring the research students gain the skills required to underpin their future careers; 25 PhD and 5 MSc students have graduated from her research team since 1997, most of whom have developed careers within the pharmaceutical industry both in Ireland and internationally.
She is Director of the interdisciplinary research centre, the Analytical and Biological Chemistry Research Facility established under PRTLI3, and has served as Head of the Department of Chemistry (2005-7) and Head of the School of Pharmacy (since 2009). She was elected to the Governing Body of University College Cork in December 2003.
She is actively engaged nationally in strategic policy development in relation to research, STI policy, the academic industry interface and strategic development of the pharmaceutical industry, including as a member of the Advisory Science Council and Irish Research Council for Science, Engineering and Technology (IRCSET). For example, she chaired the Advisory Science Council Task Force on The Role of PhDs in the Smart Economy which reported in December 2009.
Background
1985 B.Sc. (1st Hons.) at University College Cork
1989 Ph.D. at University College Cork (Prof. M.A. McKervey)
1989 Postdoctoral Associate, Facultes Universitaires, Namur, Belgium (Prof. A. Krief)
1990 Postdoctoral Fellow, University of Exeter, UK (Prof. S.M. Roberts)
1991 College Lecturer in Organic Chemistry, University College Cork
1998 Director, B.Sc. programme in The Chemistry of Pharmaceutical Compounds
2002 Director, Analytical and Biological Chemistry Research Facility
2002 Associate Professor of Organic Chemistry, University College Cork
2004 Professor of Pharmaceutical Chemistry
2004 Professor of Pharmaceutical Chemistry
Research Interests and Activities
Link to Organic and Pharmaceutical Synthesis Research Team page
· Novel synthetic methodology
- including the use of a-diazocarbonyl compounds and organosulfur compounds in synthesis
· Asymmetric synthesis
- including asymmetric catalysis and application of biotransformations in organic synthesis
· Synthesis of biologically active compounds
- current projects are targeted towards compounds with anti-viral and anti-cancer activity
· Extensive interaction with the pharmaceutical industry, within Ireland and overseas
Administrative Experience
· Member of National Research Support Fund Board from Jan.1999-Dec. 2001.
· Member of ICSTI from September 2000.
Chairman, ICSTI Task Force on Embedding the PharmaChem Sector in Ireland 2001-3.
· Member of IRCSET from June 2001.
· Vice Chairman (1998- 1999), Chairman (1999-2000) of the EU COST (European Co-operation in the Field of Scientific and Technical Research) Management Committee for Action D12 concerning "Organic Transformations: Selective Processes and Asymmetric Catalysis".
Vice Chairman (2001 to date) D24 “Sustainable Chemical Processes: Stereoselective Transition Metal-Catalysed Reactions”.
Member of Management Committee (2002 to date) D28 “Natural Products as a Source for Discovery , Synthesis and Application of New Pharmaceuticals”.
· Member of the Forfas Technology Foresight Chemical and Pharmaceutical Panel (1998)
.Research:
Anita Maguire’s research interests in Synthetic Organic Chemistry and Pharmaceutical Chemistry include:Asymmetric synthesis - including biocatalysis and transition metal catalysis;
Novel synthetic methodology - incl. the use of diazocarbonyl compounds & organosulfur compounds in synthesis;
Design and synthesis of bioactive compounds with pharmaceutical applications;
Crystal engineering;
Extensive interaction with the pharmaceutical industry both within Ireland and overseas is a key feature of the research team
Affiliations:
Elected as a Member of the Royal Irish Academy in 2014
Fellow of the Royal Society of Chemistry
Fellow of the Institute of Chemistry of Ireland
CChem
CSci
Links:
Office of VP for Research and Innovation
ABCRF and SSPC
Department of Chemistry
School of Pharmacy
Organic and Pharmaceutical Synthesis Research Team
Selected Publications
Excellent Stereocontrol in Intramolecular Buchner Cyclisations and Subsequent Cycloadditions; Stereospecific
Construction of Polycyclic Systems.
Construction of Polycyclic Systems.
A.R. Maguire, N.R. Buckley, P. O’Leary, and G. Ferguson, Chem. Commun., 1996, 2595-6.
Asymmetric Reduction of 1-Methylsulfonylalkan-2-ones with Baker's Yeast.
A.R. Maguire and D.G. Lowney, J. Chem. Soc., Perkin Trans. 1, 1997, 235 - 8.
Selective Manganese-Mediated Transformations Using the Combination : KMnO4 / Me3SiCl.
I.E. Marko, P.R. Richardson, M. Bailey, A.R. Maguire and N. Coughlan, Tetrahedron Lett., 1997, 38, 2339-42.
Enantioselective Introduction of a Benzenesulfonylmethyl Substituent at an Unactivated Carbon Atom via Chemoenzymatic
Methods.
Methods.
A.R. Maguire and L.L. Kelleher, Tetrahedron Lett., 1997, 38, 7459 - 62.
Synthesis of a-Diazo-b-Oxo Sulfoxides
A.R. Maguire, P.G. Kelleher, G. Ferguson, and J.F. Gallagher, Tetrahedron Lett., 1998, 39, 2819-22.
Rhodium Catalysed Decomposition of a-Diazosulfoxides : Formation of a-Oxo Sulfines as Intermediates
A.R. Maguire, P.G. Kelleher and S.E. Lawrence, Tetrahedron Lett., 1998, 39, 3849-52.
Stereocontrol in the Intramolecular Buchner Reaction of Diazoketones
A.R. Maguire, N.R. Buckley, P. O’Leary, and G. Ferguson, J. Chem. Soc., Perkin Trans. 1 , 1998, 4077-91.
Dynamic Kinetic Resolution in the Baker's Yeast Mediated Reduction of 2-Benzenesulfonylcycloalkanones
A.R. Maguire and N. O'Riordan, Tetrahedron Lett., 1999, 40, 9285-8.
Matrix Isolation and Photochemistry of a-Diazo Sulfoxides: Formation of an a-Oxo Sulfine as an Intermediate
W. Sander, A. Strehl, A.R. Maguire, S. Collins, and P.G. Kelleher, Eur. J. Org. Chem., 2000, 3329-3335.
Synthesis of Indomethacin Analogues for Evaluation as Moderators of MRP Activity
A.R. Maguire, S.J. Plunkett, S. Papot, M. Clynes, R. O’Connor and S. Touhey, Biorg. Med. Chem., 2001, 9, 745-762.
Enantioselective Synthesis of Sulindac
A.R. Maguire, S. Papot, A. Ford, S. Touhey, R. O’Connor, and M. Clynes, Synlett, 2001, 41-4.
4-Ethynyl-1,2-methylenedioxybenzene at 150K
S.E. Lawrence, A.J. Blake, A.R. Maguire, and E.J.A. Moynihan, Acta Cryst C, 2001, 412-413.
Dynamic Equilibria in the Products of Intramolecular Buchner Additions of Diazoketones to Aryl Rings Bearing Methoxy
Substituents
Substituents
Anita R. Maguire, Patrick O'Leary, Francis Harrington, Simon E. Lawrence and Alexander J. Blake, J. Org. Chem.,
2001, 66, 7166-7177.
2001, 66, 7166-7177.
New Methods for the Synthesis of N-Benzoylated Uridine and Thymidine Derivatives
Anita R. Maguire, Isabelle Hladezuk and Alan Ford, Carbohydrate Research, 2002, 337(4), 369-372.
Structure-Activity Relationship of Indomethacin Analogues for MRP-1, COX-1 and COX-2 Inhibition; Identification of
Novel Chemotherapeutic Drug Resistance Modulators
Novel Chemotherapeutic Drug Resistance Modulators
S. Touhey, R. O’ Connor, S.J. Plunkett, A.R. Maguire and M. Clynes, Eur. J. Cancer, 2002, 38(12), 1661-70.
Chemoenzymatic methods in the asymmetric synthesis of α-diazosulfoxides
Anita R. Maguire, Stuart G. Collins and Alan Ford, ARKIVOC, 2003, Part (vii), 96-109
Book Chapters
| Year | Publication | |
|---|---|---|
| (2013) | 'Asymmetric 1,3-dipolar cycloadditions of acrylamides in the synthesis of bioactive heterocycles' Kissane M and Maguire A R (2013) 'Asymmetric 1,3-dipolar cycloadditions of acrylamides in the synthesis of bioactive heterocycles' In: K L Ameta; R P Pawar; A J Domb (eds). Bioactive Heterocycles: Synthesis and Biological Evaluation. Hauppauge NY: Nova Science Publishers. [Details] | |
| (2011) | 'C-C Bond formation (metal-carbene catalyzed)' Ford, A and Maguire, A R (2011) 'C-C Bond formation (metal-carbene catalyzed)' In: Erick M Carreira and Hisashi Yamamoto (eds). Comprehensive Chirality. London: Elsevier Science. [Details] | |
| (2007) | 'Aryl Sulfoxides and S-Arylsulfimides' Maguire, A R, Collins, S.; (2007) 'Aryl Sulfoxides and S-Arylsulfimides' In: C. Ramsden (eds). Science of Synthesis, Volume 31a: Compounds with Two Carbon-Heteroatom Bonds, Arene-X (X = Hal, O, S, Se, Te). Stuttgart: Thieme Chemistry. [Details] | |
| (1995) | 'The Formation of One or More C=C Bond(s) by Elimination of Sulfur, Selenium, Tellurium, Nitrogen, Phosphorus, Arsenic, Antimony, Bismuth, Silicon, Germanium, Boron or Metal Functions' A.R. Maguire (1995) 'The Formation of One or More C=C Bond(s) by Elimination of Sulfur, Selenium, Tellurium, Nitrogen, Phosphorus, Arsenic, Antimony, Bismuth, Silicon, Germanium, Boron or Metal Functions' In: Alan R. Katritzky; Otho Meth-Cohn; Charles W. Rees (eds). Comprehensive Organic Functional Group Transformations, Vol I, Part II. Amsterdam: Pergamon Elsevier. [Details] |
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2014) | 'Design and synthesis of alpha-carboxy nucleoside phosphonate (alpha-CNP) analogues and evaluation as HIV-1 reverse transcriptase-targeting agents' Keane, S; Ford, A; Mullins, N; Maguire, N; Legigan, T; Balzarini, J; Maguire, A (2014) 'Design and synthesis of alpha-carboxy nucleoside phosphonate (alpha-CNP) analogues and evaluation as HIV-1 reverse transcriptase-targeting agents'. Journal of Organic Chemistry, [DOI] [Details] | |
| (2014) | 'Cocrystallization of nutraceuticals' Sinha, A; Maguire, A; Lawrence, S E. (2014) 'Cocrystallization of nutraceuticals'. Crystal Growth & Design, [DOI][Details] | |
| (2014) | 'Baker's-Yeast-Mediated Reduction of Sulfur-Containing Compounds' Deasy, RE,Maguire, AR (2014) 'Baker's-Yeast-Mediated Reduction of Sulfur-Containing Compounds'. European Journal of Organic Chemistry, 2014 :3737-3756 [DOI] [Details] | |
| (2014) | 'Synthetic and Mechanistic Aspects on the Competition between C-H Insertion and Hydride Transfer in Copper-Mediated Transformations of alpha-Diazo-beta-Keto Sulfones' Slattery, CN,Ford, A,Eccles, KS,Lawrence, SE,Maguire, AR (2014) 'Synthetic and Mechanistic Aspects on the Competition between C-H Insertion and Hydride Transfer in Copper-Mediated Transformations of alpha-Diazo-beta-Keto Sulfones'. Synlett, 25 :591-595 [DOI] [Details] | |
| (2014) | 'Preparation of 2-Aminopyridoimidazoles and 2-Aminobenzimidazoles via Phosphorus Oxychloride-Mediated Cyclization of Aminoureas' Deasy, R. E.,Slattery, C. N.,Maguire, A. R.,Kjell, D. P.,Hawk, M. K. N.,Joo, J. M.,Gu, R. L.,Moynihan, H. (2014) 'Preparation of 2-Aminopyridoimidazoles and 2-Aminobenzimidazoles via Phosphorus Oxychloride-Mediated Cyclization of Aminoureas'. Journal Of Organic Chemistryjournal Of Organic Chemistry, 79 (88):3688-3695 [Details] | |
| (2014) | 'Synthesis of novel 24-amino-25,26,27-trinorlanost-8-enes: Cytotoxic and Apoptotic Potential in U937 Cells' O’Keeffe, R.; Kenny, O.; Brunton, N. P.; Hossain, M. B.; Rai, D. K.; Jones, P. W.; O’Brien, N.; Maguire, A. R.; Collins, S. G. (2014) 'Synthesis of novel 24-amino-25,26,27-trinorlanost-8-enes: Cytotoxic and Apoptotic Potential in U937 Cells'. Bioorganic & Medicinal Chemistry, [Details] | |
| (2014) | 'Catalyst and substituent effects on the rhodium(II)-catalysed intramolecular Buchner reaction' McNamara, OA,Buckley, NR,O'Leary, P,Harrington, F,Kelly, N,O'Keeffe, S,Stack, A,O'Neill, S,Lawrence, SE,Slattery, CN,Maguire, AR (2014) 'Catalyst and substituent effects on the rhodium(II)-catalysed intramolecular Buchner reaction'. Tetrahedron, 70 :6870-6878 [DOI] [Details] | |
| (2014) | 'Crystal Landscape of Primary Aromatic Thioamides' Eccles, K. S.,Morrison, R. E.,Maguire, A. R.,Lawrence, S. E. (2014) 'Crystal Landscape of Primary Aromatic Thioamides'. Crystal Growth & Design, 14 (66):2753-2762  [Details] | |
| (2014) | 'Baker's Yeast Mediated Reduction of 2-Acetyl-3-methyl Sulfolane' Deasy, RE,O'Riordan, N,Maguire, AR (2014) 'Baker's Yeast Mediated Reduction of 2-Acetyl-3-methyl Sulfolane'.Catalysts, 4 :186-195 [DOI] [Details] | |
| (2014) | 'Hetero-Wolff Rearrangement of an a-Sulfinyl Carbene: Thermally Activated Intersystem Crossing of the Lowest Excited Triplet State of a Ground-State Singlet Carbene' O'Sullivan, O. C. M.,Collins, S. G.,Maguire, A. R.,Buche, G. (2014) 'Hetero-Wolff Rearrangement of an a-Sulfinyl Carbene: Thermally Activated Intersystem Crossing of the Lowest Excited Triplet State of a Ground-State Singlet Carbene'. European Journal of Organic Chemistry, 2014 (1111):2297-2304 [Details] | |
| (2014) | 'Enantioselective copper catalysed C-H insertion reaction of 2-sulfonyl-2-diazoacetamides to form gamma-lactams' Clarke, LA,Ring, A,Ford, A,Sinha, AS,Lawrence, SE,Maguire, AR (2014) 'Enantioselective copper catalysed C-H insertion reaction of 2-sulfonyl-2-diazoacetamides to form gamma-lactams'. Organic & Biomolecular Chemistry, 12 :7612-7628 [DOI] [Details] | |
| (2014) | 'Insight into the Mechanism of Formation of Channel Hydrates via Templating' Stokes, SP,Seaton, CC,Eccles, KS,Maguire, AR,Lawrence, SE (2014) 'Insight into the Mechanism of Formation of Channel Hydrates via Templating'. Crystal Growth & Design, 14 :1158-1166 [DOI] [Details] | |
| (2014) | 'Taming Hazardous Chemistry in Flow: The Continuous Processing of Diazo and Diazonium Compounds' Deadman, B. J.; Collins, S. G.; Maguire, A. R. (2014) 'Taming Hazardous Chemistry in Flow: The Continuous Processing of Diazo and Diazonium Compounds'. Chemistry-A European Journal, [Details] | |
| (2013) | 'Cytotoxic and apoptotic potential of potato glycoalkaloids in a number of cancer cell lines' Kenny, O. M; Brunton, N. P.; Rai, D. K.; Collins, S. G.; Jones, P. W.; Maguire, A. R.; O'Brien, N. M (2013) 'Cytotoxic and apoptotic potential of potato glycoalkaloids in a number of cancer cell lines'. Journal of Agricultural Science and Applications, 2 (4):184-192 [Details] | |
| (2013) | 'Synthesis and assessment of the relative toxicity of the oxidised derivatives of campesterol and dihydrobrassicasterol in U937 and HepG2 cells' O'Callaghan Y, Kenny O, O'Connell NM, Maguire AR, McCarthy FO, O'Brien NM (2013) 'Synthesis and assessment of the relative toxicity of the oxidised derivatives of campesterol and dihydrobrassicasterol in U937 and HepG2 cells'.Biochimie, 95 (3):496-503 [DOI] [Details] | |
| (2013) | 'Electronic effects of aryl-substituted bis(oxazoline) ligands on the outcome of asymmetric copper-catalysed C-H insertion and aromatic addition reactions' Slattery, CN,O'Keeffe, S,Maguire, AR (2013) 'Electronic effects of aryl-substituted bis(oxazoline) ligands on the outcome of asymmetric copper-catalysed C-H insertion and aromatic addition reactions'. Tetrahedron-Asymmetry, 24 :1265-1275 [DOI] [Details] | |
| (2013) | 'Investigation of steric and electronic effects in the copper-catalysed asymmetric oxidation of sulfides' O'Mahony, G. E.,Eccles, K. S.,Morrison, R. E.,Ford, A.,Lawrence, S. E.,Maguire, A. R. (2013) 'Investigation of steric and electronic effects in the copper-catalysed asymmetric oxidation of sulfides'. Tetrahedrontetrahedron, 69 (4747):10168-10184 [Details] | |
| (2013) | 'Copper-catalysed enantioselective intramolecular C-H insertion reactions of alpha-diazo-beta-keto esters and alpha-diazo-beta-keto phosphonates' Slattery, CN,Maguire, AR (2013) 'Copper-catalysed enantioselective intramolecular C-H insertion reactions of alpha-diazo-beta-keto esters and alpha-diazo-beta-keto phosphonates'. Tetrahedron Letters, 54 :2799-2801 [DOI] [Details] | |
| (2013) | 'Asymmetric oxidation of sulfides' O'Mahony, GE,Ford, A,Maguire, AR (2013) 'Asymmetric oxidation of sulfides'. Journal Of Sulfur Chemistry, 34 :301-341 [DOI] [Details] | |
| (2013) | 'Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages' Kenny, O. M; McCarthy, C. M; Brunton, N. P.; Hossain, M. B.; Rai, D. K.; Collins, S. G.; Jones, P. W.; Maguire, A. R.; O'Brien, N. M. (2013) 'Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages'. Life Sciences, 92 :775-782 [Details] | |
| (2013) | 'Synthetic approaches to the daucane sesquiterpene derivatives employing the intramolecular Buchner cyclisation of alpha-diazoketones' Foley, David A.,O'Leary, Patrick,Buckley, N. Rachael,Lawrence, Simon E.,Maguire, Anita R. (2013) 'Synthetic approaches to the daucane sesquiterpene derivatives employing the intramolecular Buchner cyclisation of alpha-diazoketones'. Tetrahedron, 69 (6):1778-1794 [Details] | |
| (2013) | 'Telescoped Approach to Aryl Hydroxymethylation in the Synthesis of a Key Pharmaceutical Intermediate' Slattery, C. N.,Deasy, R. E.,Maguire, A. R.,Kopach, M. E.,Singh, U. K.,Argentine, M. D.,Trankle, W. G.,Scherer, R. B.,Moynihan, H. (2013) 'Telescoped Approach to Aryl Hydroxymethylation in the Synthesis of a Key Pharmaceutical Intermediate'. Journal of Organic Chemistry, 78 (1212):5955-5963 [Details] | |
| (2013) | 'Catalyst, additive and counterion effects on the efficiency and enantioselectivity of copper-catalysed C-H insertion reactions of alpha-diazosulfones' Slattery, Catherine N. and Clarke, Leslie-Ann and Ford, Alan and Maguire, Anita R. (2013) 'Catalyst, additive and counterion effects on the efficiency and enantioselectivity of copper-catalysed C-H insertion reactions of alpha-diazosulfones'. Tetrahedron, 69 (4):1297-1301 [Details] | |
| (2013) | 'Total synthesis of padanamides A and B' Long, BH,Tang, SB,Chen, LG,Qu, SW,Chen, B,Liu, JY,Maguire, AR,Wang, Z,Liu, YQ,Zhang, H,Xu, ZS,Ye, T (2013) 'Total synthesis of padanamides A and B'. Chemical Communications, 49 :2977-2979 [DOI] [Details] | |
| (2013) | 'Design and synthesis of stable alpha-diazo-beta-oxo sulfoxides' Collins, SG,O'Sullivan, OCM,Kelleher, PG,Maguire, AR (2013) 'Design and synthesis of stable alpha-diazo-beta-oxo sulfoxides'. Organic & Biomolecular Chemistry, 11 :1706-1725 [DOI] [Details] | |
| (2013) | 'Synthesis and evaluation of novel ellipticines as potential anti-cancer agents' Deane, FM,O'Sullivan, EC,Maguire, AR,Gilbert, J,Sakoff, JA,McCluskey, A,McCarthy, FO (2013) 'Synthesis and evaluation of novel ellipticines as potential anti-cancer agents'. Organic & Biomolecular Chemistry, 11 :1334-1344[DOI] [Details] | |
| (2013) | 'Total Synthesis and Biological Evaluation of Grassypeptolide A' Liu, H,Liu, YQ,Wang, Z,Xing, XY,Maguire, AR,Luesch, H,Zhang, H,Xu, ZS,Ye, T (2013) 'Total Synthesis and Biological Evaluation of Grassypeptolide A'. Chemistry-A European Journal, 19 :6774-6784 [DOI] [Details] | |
| (2013) | 'Influence of the position of the substituent on the efficiency of lipase-mediated resolutions of 3-aryl alkanoic acids' Deasy, RE,Moody, TS,Maguire, AR (2013) 'Influence of the position of the substituent on the efficiency of lipase-mediated resolutions of 3-aryl alkanoic acids'. Tetrahedron-Asymmetry, 24 :1480-1487 [DOI] [Details] | |
| (2013) | 'A novel CyclinE/CyclinA-CDK Inhibitor targets p27(Kip1) degradation, cell cycle progression and cell survival: Implications in cancer therapy' Dai, L,Liu, YQ,Liu, JY,Wen, XM,Xu, ZS,Wang, Z,Sun, H,Tang, SB,Maguire, AR,Quan, JM,Zhang, H,Ye, T (2013) 'A novel CyclinE/CyclinA-CDK Inhibitor targets p27(Kip1) degradation, cell cycle progression and cell survival: Implications in cancer therapy'. Cancer Letters, 333 :103-112 [DOI] [Details] | |
| (2013) | 'Co-crystallisation through halogen bonding with racemic or enantiopure sulfinamides' Eccles, Kevin S.,Morrison, Robin E.,Daly, Carla A.,O'Mahony, Graham E.,Maguire, Anita R.,Lawrence, Simon E. (2013) 'Co-crystallisation through halogen bonding with racemic or enantiopure sulfinamides'. CrystEngComm, 15 (37):7571-7575 [Details] | |
| (2012) | 'Biocatalytic Approaches to the Henry (Nitroaldol) Reaction' Milner, SE,Moody, TS,Maguire, AR (2012) 'Biocatalytic Approaches to the Henry (Nitroaldol) Reaction'. European Journal of Organic Chemistry, :3059-3067 [DOI] [Details] | |
| (2012) | 'Asymmetric Synthesis of cis-7-Methoxycalamenene via the Intramolecular Buchner Reaction of an alpha-Diazoketone' McDowell PA, Foley DA, O'Leary P, Ford A, Maguire AR (2012) 'Asymmetric Synthesis of cis-7-Methoxycalamenene via the Intramolecular Buchner Reaction of an alpha-Diazoketone'. The Journal of Organic Chemistry, 77 (4):2035-2040 [DOI] [Details] | |
| (2012) | 'Understanding the p-Toluenesulfonamide/Triphenylphosphine Oxide Crystal Chemistry: A New 1:1 Cocrystal and Ternary Phase Diagram' Croker, Denise M.; Foreman, Michael E.; Hogan, Bridget N.; Maguire, Nuala M.; Elcoate, Curtis J.; Hodnett, Benjamin K.; Maguire, Anita R.; Rasmuson, Ake C.; Lawrence, Simon E. (2012) 'Understanding the p-Toluenesulfonamide/Triphenylphosphine Oxide Crystal Chemistry: A New 1:1 Cocrystal and Ternary Phase Diagram'. Crystal Growth & Design, 12 (2):869-875 [DOI] [Full Text] [Details] | |
| (2012) | 'Utilizing Sulfoxide•••Iodine Halogen Bonding for Cocrystallization' By Eccles, Kevin S.; Morrison, Robin E.; Stokes, Stephen P.; O'Mahony, Graham E.; Hayes, John A.; Kelly, Dawn M.; O'Boyle, Noel M.; Fabian, Laszlo; Moynihan, Humphrey A.; Maguire, Anita R, Lawrence, Simon E. (2012) 'Utilizing Sulfoxide•••Iodine Halogen Bonding for Cocrystallization'. Crystal Growth & Design, 12 (6):2969-2977 [DOI][Details] | |
| (2012) | 'Investigation of Additive Effects in Enantioselective Copper-Catalysed C-H Insertion and Aromatic Addition Reactions of alpha-Diazocarbonyl Compounds' Slattery, CN,Clarke, LA,O'Neill, S,Ring, A,Ford, A,Maguire, AR (2012) 'Investigation of Additive Effects in Enantioselective Copper-Catalysed C-H Insertion and Aromatic Addition Reactions of alpha-Diazocarbonyl Compounds'. Synlett, :765-767 [DOI] [Details] | |
| (2012) | 'Characterisation, solubility and intrinsic dissolution behaviour of benzamide: dibenzyl sulfoxide cocrystal' Grossjohann, C,Eccles, KS,Maguire, AR,Lawrence, SE,Tajber, L,Corrigan, OI,Healy, AM (2012) 'Characterisation, solubility and intrinsic dissolution behaviour of benzamide: dibenzyl sulfoxide cocrystal'. International Journal of Pharmaceutics, 422 :24-32 [DOI] [Full Text] [Details] | |
| (2012) | 'Expanded scope of heterocyclic biaryl synthesis via a palladium-catalysed thermal decarboxylative cross-coupling reaction' Kissane, M,McNamara, OA,Mitchell, D,Coppert, DM,Moynihan, HA,Lorenz, KT,Maguire, AR (2012) 'Expanded scope of heterocyclic biaryl synthesis via a palladium-catalysed thermal decarboxylative cross-coupling reaction'.Tetrahedron Letters, 53 :403-405 [DOI] [Details] | |
| (2012) | 'Development of O-H insertion for the attachment of phosphonates to nucleosides; synthesis of alpha-carboxy phosphononucleosides' Hladezuk, I,Chastagner, V,Collins, SG,Plunkett, SJ,Ford, A,Debarge, S,Maguire, AR (2012) 'Development of O-H insertion for the attachment of phosphonates to nucleosides; synthesis of alpha-carboxy phosphononucleosides'.Tetrahedron, 68 :1894-1909 [DOI] [Details] | |
| (2012) | 'Oxidized Derivatives of Dihydrobrassicasterol: Cytotoxic and Apoptotic Potential in U937 and HepG2 Cells' Kenny, O,O'Callaghan, Y,O'Connell, NM,McCarthy, FO,Maguire, AR,O'Brien, NM (2012) 'Oxidized Derivatives of Dihydrobrassicasterol: Cytotoxic and Apoptotic Potential in U937 and HepG2 Cells'. Journal of Agricultural and Food Chemistry, 60 :5952-5961 [DOI] [Details] | |
| (2012) | 'Synthetic routes to campesterol and dihydrobrassicasterol: a first reported synthesis of the key phytosterol dihydrobrassicasterol' O'Connell, NM,O'Callaghan, YC,O'Brien, NM,Maguire, AR,McCarthy, FO (2012) 'Synthetic routes to campesterol and dihydrobrassicasterol: a first reported synthesis of the key phytosterol dihydrobrassicasterol'. Tetrahedron, 68 :4995-5004 [DOI] [Details] | |
| (2012) | 'Copper-Catalyzed Asymmetric Oxidation of Sulfides' O'Mahony GE, Ford A, Maguire AR (2012) 'Copper-Catalyzed Asymmetric Oxidation of Sulfides'. The Journal of Organic Chemistry, [DOI] [Details] | |
| (2012) | 'Recent Trends in Whole Cell and Isolated Enzymes in Enantioselective Synthesis' Maguire, AR; Milner SE (2012) 'Recent Trends in Whole Cell and Isolated Enzymes in Enantioselective Synthesis'.Arkivoc, (i):321-382 [Details] | |
| (2012) | 'Investigating the influence of the sulfur oxidation state on solid state' Daly, Carla A.; Eccles, Kevin S.; Bateman, Lorraine M.; O'Boyle, Noel M.; Lawrence, Simon E.; Maguire, Anita R. (2012) 'Investigating the influence of the sulfur oxidation state on solid state'. Crystal Engineering Communications, 14 (23):7848-7850 [Details] | |
| (2011) | 'Modifications to the Vilsmeier-Haack formylation of 1,4-dimethylcarbazole and its application to the synthesis of ellipticines' Deane, FM; Miller, CM; Maguire, AR; McCarthy, FO; (2011) 'Modifications to the Vilsmeier-Haack formylation of 1,4-dimethylcarbazole and its application to the synthesis of ellipticines'. Journal of Heterocyclic Chemistry, 48 (4):814-823 [DOI] [Details] | |
| (2011) | 'ReactNMR and ReactIR as Reaction Monitoring and Mechanistic Elucidation Tools: The NCS Mediated Cascade Reaction of alpha-Thioamides to alpha-Thio-beta-chloroacrylamides' Foley, DA,Doecke, CW,Buser, JY,Merritt, JM,Murphy, L,Kissane, M,Collins, SG,Maguire, AR,Kaerner, A (2011) 'ReactNMR and ReactIR as Reaction Monitoring and Mechanistic Elucidation Tools: The NCS Mediated Cascade Reaction of alpha-Thioamides to alpha-Thio-beta-chloroacrylamides'. The Journal of Organic Chemistry, 76 :9630-9640 [DOI] [Details] | |
| (2011) | 'Cocrystals of Fenamic Acids with Nicotinamide' Fabian, L,Hamill, N,Eccles, KS,Moynihan, HA,Maguire, AR,McCausland, L,Lawrence, SE; (2011) 'Cocrystals of Fenamic Acids with Nicotinamide'. Crystal Growth & Design, 11 :3522-3528 [DOI] [Full Text] [Details] | |
| (2011) | 'A Practical Synthesis of Biaryls via a Thermal Decarboxylative Pd-Catalyzed Cross-Coupling Reaction Operating at Moderate Temperature' Mitchell, D,Coppert, DM,Moynihan, HA,Lorenz, KT,Kissane, M,McNamara, OA,Maguire, AR; (2011) 'A Practical Synthesis of Biaryls via a Thermal Decarboxylative Pd-Catalyzed Cross-Coupling Reaction Operating at Moderate Temperature'. Organic Process Research & Development, 15 :981-985 [DOI] [Details] | |
| (2011) | 'Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids' Rebecca E Deasy, Maude Brossat, Thomas S Moody and Anita R Maguire (2011) 'Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids'. Tetrahedron: Asymmetry, 22 :47-61 [Full Text] [Details] | |
| (2011) | 'Evaluation of the Bruker SMART X2S: crystallography for the nonspecialist?' Eccles, KS,Stokes, SP,Daly, CA,Barry, NM,McSweeney, SP,O'Neill, DJ,Kelly, DM,Jennings, WB,Dhubhghaill, OMN,Moynihan, HA,Maguire, AR,Lawrence, SE; (2011) 'Evaluation of the Bruker SMART X2S: crystallography for the nonspecialist?'. Journal of Applied Crystallography, 44 :213-215 [DOI] [Full Text] [Details] | |
| (2011) | 'Confab - Systematic generation of diverse low-energy conformers' O'Boyle NM, Vandermeersch T, Flynn CJ, Maguire AR, Hutchison GR; (2011) 'Confab - Systematic generation of diverse low-energy conformers'. Journal of cheminformatics, 3 [DOI] [Full Text] [Details] | |
| (2011) | 'Asymmetric copper-catalysed intramolecular C-H insertion reactions of alpha-diazo-beta-keto sulfones' Slattery, Catherine N. and Maguire, Anita R. (2011) 'Asymmetric copper-catalysed intramolecular C-H insertion reactions of alpha-diazo-beta-keto sulfones'. Organic & Biomolecular Chemistry, 9 (3):667-669 [Details] | |
| (2011) | 'Synthesis of enantioenriched sulfoxides' O'Mahony, Graham E. and Kelly, Padraig and Lawrence, Simon E. and Maguire, Anita R. (2011) 'Synthesis of enantioenriched sulfoxides'. Arkivoc, :1-110 [Full Text] [Details] | |
| (2011) | 'Pleiotropic role for monocyte C-fms protein in response to vascular injury: Potential therapeutic target' Metharom P, Martin K, Kumar AH, Sawhney N, Cronin MF, McCarthy DG, Maguire AR, Caplice NM; (2011) 'Pleiotropic role for monocyte C-fms protein in response to vascular injury: Potential therapeutic target'.Atherosclerosis, 216 (1):74-82 [Details] | |
| (2011) | 'Selective beta-oxidation of alpha-sulfanyl amides' Kissane, Marie and Murphy, Maureen and Bateman, Lorraine M. and McCarthy, Daniel G. and Maguire, Anita R. (2011) 'Selective beta-oxidation of alpha-sulfanyl amides'. Tetrahedron, 67 (30):5494-5499 [DOI] [Full Text] [Details] | |
| (2011) | 'Stereoselective Synthesis of 2-Thio-3-Chloroacrylamides and Investigation of their Reactivity' Kissane, Marie and Maguire, Anita R. (2011) 'Stereoselective Synthesis of 2-Thio-3-Chloroacrylamides and Investigation of their Reactivity'. Synlett, (9):1212-1232 [Details] | |
| (2011) | 'Expanding the crystal landscape of isonicotinamide: concomitant polymorphism and co-crystallisation' Eccles, Kevin S. and Deasy, Rebecca E. and Fabian, Laszlo and Braun, Doris E. and Maguire, Anita R. and Lawrence, Simon E. (2011) 'Expanding the crystal landscape of isonicotinamide: concomitant polymorphism and co-crystallisation'. Crystal Engineering Communications, 13 (23):6923-6925 [Details] | |
| (2011) | 'Bioactivities of Glycoalkaloids and Their Aglycones from Solanum Species' Milner, Sinead Eileen and Brunton, Nigel Patrick and Jones, Peter Wyn and O'Brien, Nora Mary and Collins, Stuart Gerard and Maguire, Anita Rose (2011) 'Bioactivities of Glycoalkaloids and Their Aglycones from Solanum Species'.Journal of Agricultural and Food Chemistry, 59 (8):3454-3484 [Details] | |
| (2011) | 'Addition-substitution reactions of 2-thio-3-chloroacrylamides with carbon, nitrogen, oxygen, sulfur and selenium nucleophiles' Kissane, M. and Murphy, M. and O'Brien, E. and Chopra, J. and Murphy, L. and Collins, S. G. and Lawrence, S. E. and Maguire, A. R.; (2011) 'Addition-substitution reactions of 2-thio-3-chloroacrylamides with carbon, nitrogen, oxygen, sulfur and selenium nucleophiles'. Organic and Biomolecular Chemistry, 9 :2452-2472 [Full Text] [Details] | |
| (2011) | 'Design and Synthesis of alpha-Carboxy Phosphononucleosides' Debarge, S,Balzarini, J,Maguire, AR; (2011) 'Design and Synthesis of alpha-Carboxy Phosphononucleosides'. The Journal of Organic Chemistry, 76 :105-126 [DOI] [Details] | |
| (2011) | 'The Use of Co-crystals for the Determination of Absolute Stereochemistry: An Alternative to Salt Formation' Eccles, KS,Deasy, RE,Fabian, L,Maguire, AR,Lawrence, SE; (2011) 'The Use of Co-crystals for the Determination of Absolute Stereochemistry: An Alternative to Salt Formation'. The Journal of Organic Chemistry, 76 :1159-1162[DOI] [Details] | |
| (2011) | 'The norcaradiene-cycloheptatriene equilibrium' McNamara, OA,Maguire, AR; (2011) 'The norcaradiene-cycloheptatriene equilibrium'. Tetrahedron, 67 :9-40 [DOI][Details] | |
| (2011) | 'A practical chemo-enzymatic approach to highly enantio-enriched cyanohydrin acetates' Maguire, NM,Ford, A,Clarke, SL,Eccles, KS,Lawrence, SE,Brossat, M,Moody, TS,Maguire, AR (2011) 'A practical chemo-enzymatic approach to highly enantio-enriched cyanohydrin acetates'. Tetrahedron-Asymmetry, 22 :2144-2150 [DOI] [Details] | |
| (2011) | 'Unzipping the Dimer in Primary Amides by Cocrystallization with Sulfoxides' Eccles, KS,Elcoate, CJ,Maguire, AR,Lawrence, SE (2011) 'Unzipping the Dimer in Primary Amides by Cocrystallization with Sulfoxides'. Crystal Growth & Design, 11 :4433-4439 [DOI] [Details] | |
| (2010) | 'Highly enantioselective intramolecular copper catalyzed C-H insertion reactions of alpha-diazosulfones' Flynn, CJ; Elcoate, CJ; Lawrence, SE; Maguire, AR; (2010) 'Highly enantioselective intramolecular copper catalyzed C-H insertion reactions of alpha-diazosulfones'. Journal of the American Chemical Society, 132 (4):1184-1185 [DOI][Details] | |
| (2010) | 'Asymmetric 1,3-dipolar cycloadditions of acrylamides' Kissane, M; Maguire, AR; (2010) 'Asymmetric 1,3-dipolar cycloadditions of acrylamides'. Chemical Society Reviews, 39 (2):845-883 [DOI] [Full Text] [Details] | |
| (2010) | 'Diastereoselective sulfur oxidation of 2-thio-3-chloroacrylamides' Kissane, Marie; Lawrence, Simon E; Maguire, Anita R (2010) 'Diastereoselective sulfur oxidation of 2-thio-3-chloroacrylamides'. Tetrahedron: Asymmetry, 21 :871-884 [Full Text] [Details] | |
| (2010) | '1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones' Kissane, Marie; Lawrence, Simon E; Maguire, Anita R (2010) '1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones'. Tetrahedron, 66 :4564-4572 [DOI] [Full Text] [Details] | |
| (2010) | 'Catalytic Asymmetric C-H Insertion Reactions of alpha-Diazocarbonyl Compounds' Slattery, Catherine N; Ford, Alan; Maguire, Anita R; (2010) 'Catalytic Asymmetric C-H Insertion Reactions of alpha-Diazocarbonyl Compounds'. Tetrahedron, 66 (34):6681-6705 [Full Text] [Details] | |
| (2010) | 'The influence of reaction conditions on the Diels-Alder cycloadditions of 2-thio-3-chloroacrylamides; investigation of thermal, catalytic and microwave conditions' Kissane, Marie; Lynch, Denis; Chopra, Jay; Lawrence, Simon E; Maguire, Anita R; (2010) 'The influence of reaction conditions on the Diels-Alder cycloadditions of 2-thio-3-chloroacrylamides; investigation of thermal, catalytic and microwave conditions'. Organic and Biomolecular Chemistry, 8 (24):5602-5613 [DOI] [Full Text] [Details] | |
| (2010) | 'Cytotoxic and Apoptotic Effects of the Oxidized Derivatives of Stigmasterol in the U937 Human Monocytic Cell Line' O'Callaghan YC, Foley DA, O'Connell NM, McCarthy FO, Maguire AR, O'Brien NM; (2010) 'Cytotoxic and Apoptotic Effects of the Oxidized Derivatives of Stigmasterol in the U937 Human Monocytic Cell Line'. Journal of Agricultural and Food Chemistry, 58 :10793-10798 [DOI] [Details] | |
| (2010) | 'Process Development and Pilot-Plant Synthesis of (2-Chlorophenyl)[2-(phenylsulfonyl)pyridin-3-yl]methanone' Kopach, Michael E; Kobierski, Michael E; Coffey, D. Scott; Alt, Charles A; Zhang, Tony; Borghese, Alfio; Trankle, William G; Roberts, Dilwyn J; Moynihan, Humphrey; Lorenz, Kurt; McNamara, Oria A; Kissane, Marie; Maguire, Anita R; (2010) 'Process Development and Pilot-Plant Synthesis of (2-Chlorophenyl)[2-(phenylsulfonyl)pyridin-3-yl]methanone'. Organic Process Research & Development, 14 (5):1229-1238 [DOI] [Details] | |
| (2010) | 'Efficient kinetic bioresolution of 2-nitrocyclohexanol' Milner, Sinead E; Brossat, Maude; Moody, Thomas S; Elcoate, Curtis J; Lawrence, Simon E; Maguire, Anita R; (2010) 'Efficient kinetic bioresolution of 2-nitrocyclohexanol'. Tetrahedron: Asymmetry, 21 (88):1011-1016 [Details] | |
| (2010) | '1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with diazoalkanes' Kissane, Marie; Lawrence, Simon E; Maguire, Anita R; (2010) '1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with diazoalkanes'. Organic and Biomolecular Chemistry, 8 (1212):2735-2748 [Full Text] [Details] | |
| (2010) | 'Sulfoxides: Potent Co-Crystal Formers' Eccles, Kevin S.,Elcoate, Curtis J.,Stokes, Stephen P.,Maguire, Anita R.,Lawrence, Simon E.; (2010) 'Sulfoxides: Potent Co-Crystal Formers'. Crystal Growth & Design, 10 (10):4243-4245 [Full Text] [Details] | |
| (2010) | 'Synthesis and Characterization of Stigmasterol Oxidation Products' Foley, David A; O'Callaghan, Yvonne; O'Brien, Nora M; McCarthy, Florence O; Maguire, Anita R; (2010) 'Synthesis and Characterization of Stigmasterol Oxidation Products'. Journal of agricultural and food chemistry, 58 (2):1165-1173 [DOI] [Details] | |
| (2010) | 'Convenient and robust one-pot synthesis of symmetrical and unsymmetrical benzyl thioethers from benzyl halides using thiourea' Eccles, KS,Elcoate, CJ,Lawrence, SE,Maguire, AR; (2010) 'Convenient and robust one-pot synthesis of symmetrical and unsymmetrical benzyl thioethers from benzyl halides using thiourea'. Arkivoc, ((ix)):216-228 [Full Text] [Details] | |
| (2010) | 'Synthesis and stereoselective oxidation of alpha-thio-beta-chloropropenyloxazolidin-2-ones' Kissane, M,Murphy, M,Lawrence, SE,Maguire, AR; (2010) 'Synthesis and stereoselective oxidation of alpha-thio-beta-chloropropenyloxazolidin-2-ones'. Tetrahedron: Asymmetry, 21 :2550-2558 [DOI] [Full Text] [Details] | |
| (2010) | 'Does intermolecular S = O...H-C-S = O hydrogen bonding in sulfoxides and sulfones provide a robust supramolecular synthon in the solid state?' Brondel, N,Moynihan, EJA,Lehane, KN,Eccles, KS,Elcoate, CJ,Coles, SJ,Lawrence, SE,Maguire, AR; (2010) 'Does intermolecular S = O...H-C-S = O hydrogen bonding in sulfoxides and sulfones provide a robust supramolecular synthon in the solid state?'. Crystengcomm, 12 :2910-2927 [DOI] [Details] | |
| (2010) | 'Synthetic approaches to bicyclo[5.3.0]decane sesquiterpenes' Foley, DA,Maguire, AR (2010) 'Synthetic approaches to bicyclo[5.3.0]decane sesquiterpenes'. Tetrahedron, :1131-1175 [DOI] [Details] | |
| (2009) | 'Phytosterol Oxidation Products: Their Formation, Occurrence, and Biological Effects' E. Ryan, F. O. McCarthy, A. R. Maguire and N. M. O'Brien. ; (2009) 'Phytosterol Oxidation Products: Their Formation, Occurrence, and Biological Effects'. Food Reviews International, 25 :157-174 [Details] | |
| (2009) | 'Efficient construction of novel carbocyclic frameworks via intramolecular aromatic addition of diazoketones followed by Diels-Alder cycloaddition' O'Leary, P,Maguire, AR; (2009) 'Efficient construction of novel carbocyclic frameworks via intramolecular aromatic addition of diazoketones followed by Diels-Alder cycloaddition'. Arkivoc, :130-151 [Details] | |
| (2009) | 'Synthesis of aryl benzyl NH-sulfoximines' Barry, N,Brondel, N,Lawrence, SE,Maguire, AR; (2009) 'Synthesis of aryl benzyl NH-sulfoximines'. Tetrahedron, 65 :10660-10670 [DOI] [Details] | |
| (2009) | 'Enhancement of Enantioselection in the Copper-Catalysed Intramolecular Buchner Reaction by Variation of the Counterion' O'Neill, S,O'Keeffe, S,Harrington, F,Maguire, AR; (2009) 'Enhancement of Enantioselection in the Copper-Catalysed Intramolecular Buchner Reaction by Variation of the Counterion'. Synlett, :2312-2314 [DOI] [Details] | |
| (2008) | 'Microwave-assisted reactions of alpha-diazosulfoxides to form alpha-oxo sulfines' O'Sullivan, Orlagh C. M.; Collins, Stuart G.; Maguire, Anita R.; (2008) 'Microwave-assisted reactions of alpha-diazosulfoxides to form alpha-oxo sulfines'. Synlett, 5 :659-662 [Details] | |
| (2008) | 'Investigation of the chemoselective and enantioselective oxidation of alpha-thio-beta-chloroacrylamides' M. Kissane, D. Lynch, J. Chopra, S.E. Lawrence, A.R. Maguire; (2008) 'Investigation of the chemoselective and enantioselective oxidation of alpha-thio-beta-chloroacrylamides'. Tetrahedron: Asymmetry, 19 (10):1256-1273 [DOI][Full Text] [Details] | |
| (2008) | 'Investigation of The Reaction of alpha-Thioamides, alpha-Esters and alpha-Nitriles With N-Halosuccinimides' Kissane, M, Murphy, M, Lynch, D, Ford, A, Maguire, AR; (2008) 'Investigation of The Reaction of alpha-Thioamides, alpha-Esters and alpha-Nitriles With N-Halosuccinimides'. Tetrahedron, 64 (32):7639-7649 [DOI] [Full Text] [Details] | |
| (2008) | 'Engineered dehydrogenase biocatalysts for non-natural amino acids: efficient isolation of the D-enantiomer from racemic mixtures' Paradisi, F,Conway, PA,Maguire, AR,Engel, PC; (2008) 'Engineered dehydrogenase biocatalysts for non-natural amino acids: efficient isolation of the D-enantiomer from racemic mixtures'. Organic and Biomolecular Chemistry, 6 :3611-3615 [DOI] [Details] | |
| (2007) | 'Enantioselective Intramolecular Buchner Reaction of alpha-Diazoketones' O'Keeffe, S, Harrington, F, Maguire, AR; (2007) 'Enantioselective Intramolecular Buchner Reaction of alpha-Diazoketones'. Synlett, -1 (15):2367-2370 [DOI] [Details] | |
| (2007) | 'Impact of sulfur substituents on the C H...O interaction of terminal alkynes in crystal engineering' K N Lehane, E J A Moynihan, N Brondel, S E Lawrence, A R Maguire; (2007) 'Impact of sulfur substituents on the C H...O interaction of terminal alkynes in crystal engineering'. Crystal Engineering Communications, * (*):*-* [Details] | |
| (2007) | 'Phenylalanine dehydrogenase mutants: efficient biocatalysts for synthesis of non-natural phenylalanine derivatives' Paradisi F, Collins S, Maguire AR, Engel PC; (2007) 'Phenylalanine dehydrogenase mutants: efficient biocatalysts for synthesis of non-natural phenylalanine derivatives'. Journal of Biotechnology, 128 (2):408-411 [DOI] [Details] | |
| (2007) | 'Investigation of the synthetic and mechanistic aspects of the highly stereoselective transformation of alpha-thioamides to alpha-thio-beta-chloroacrylamides' O'brien E, Murphy M, Lynch D, Schaeffer M, Kissane M, Chopra J, Ford A, Ferguson G, Maguire AR; (2007) 'Investigation of the synthetic and mechanistic aspects of the highly stereoselective transformation of alpha-thioamides to alpha-thio-beta-chloroacrylamides'. Organic and Biomolecular Chemistry, 5 (8):1228-1241 [DOI][Details] | |
| (2007) | 'Selective release of DNA from the surface of indium- tin oside thin electrode films using thiol-disulfide' E S Moore, M Curtin, J Ionita, A R Maguire, G Ceccone, P Galvin; (2007) 'Selective release of DNA from the surface of indium- tin oside thin electrode films using thiol-disulfide'. Analytical Chemistry, * (79):2050-* [Details] | |
| (2007) | 'Phytosterol, squalene, tocopherol content and fatty acid profile of selected seeds, grains, and legumes' Ryan, E,Galvin, K,O'Connor, TP,Maguire, AR,O'Brien, NM; (2007) 'Phytosterol, squalene, tocopherol content and fatty acid profile of selected seeds, grains, and legumes'. Plant Foods For Human Nutrition, 62 :85-91 [DOI][Details] | |
| (2007) | 'Chemoselectivity and enantioselectivity in copper-catalysed oxidation of aryl benzyl sulfides' Kelly, P,Lawrence, SE,Maguire, AR; (2007) 'Chemoselectivity and enantioselectivity in copper-catalysed oxidation of aryl benzyl sulfides'. Synlett, :1501-1506 [DOI] [Details] | |
| (2006) | 'Asymmetric Synthesis of Aryl Benzyl Sulfoxides By Vanadium-Catalysed Oxidation: A Combination of Enantioselective Sulfide Oxidation and Kinetic Resolution In Sulfoxide Oxidation' Kelly, P, Lawrence, SE, Maguire, AR; (2006) 'Asymmetric Synthesis of Aryl Benzyl Sulfoxides By Vanadium-Catalysed Oxidation: A Combination of Enantioselective Sulfide Oxidation and Kinetic Resolution In Sulfoxide Oxidation'. European Journal of Organic Chemistry, -1 (19):4500-4509 [DOI] [Details] | |
| (2006) | 'Kinetic resolution in vanadium-catalyzed sulfur oxidation as an efficient route to enantiopure aryl benzyl sulfoxides' Kelly, P; Lawrence, SE; Maguire, AR; (2006) 'Kinetic resolution in vanadium-catalyzed sulfur oxidation as an efficient route to enantiopure aryl benzyl sulfoxides'. Synlett, 10 (*):1569-1573 [Details] | |
| (2006) | 'Fatty acid profile, tocopherol, squalene and phytosterol content of brazil, pecan, pine, pistachio and cashew nuts' Ryan E, Galvin K, O'Connor TP, Maguire AR, O'Brien NM; (2006) 'Fatty acid profile, tocopherol, squalene and phytosterol content of brazil, pecan, pine, pistachio and cashew nuts'. International Journal of Food Sciences and Nutrition, 57 (3-4):219-228 [DOI] [Details] | |
| (2006) | 'Photochemistry of cis-3-diazo-5,6-dimethyl-1,4-oxathian-2-one S-oxide in argon matrices' O'Sullivan, OCM,Collins, SG,Maguire, AR,Bohm, M,Sander, W; (2006) 'Photochemistry of cis-3-diazo-5,6-dimethyl-1,4-oxathian-2-one S-oxide in argon matrices'. European Journal of Organic Chemistry, :2918-2924 [DOI] [Details] | |
| (2005) | 'Desmethylabietospiran, a naturally occurring self-gelation agent' O'Neill JA, Gallagher OP, Devine KJ, Jones PW, Maguire AR; (2005) 'Desmethylabietospiran, a naturally occurring self-gelation agent'. Journal of Natural Products, 68 (1):125-128 [DOI] [Details] | |
| (2005) | 'Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products' E. Ryan;J. Chopra;F. McCarthy;A. R. Maguire;N. M. O'Brien; (2005) 'Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products'. British Journal of Nutrition, 94 :443-451 [DOI] [Full Text] [Details] | |
| (2005) | 'Phytosterol, Tocopherol and Squalene Content of Five Edible Nuts (Brazil, Pecan, Pine, Pistachio, Cashew)' Ryan, E, Galvin, K, O'Connor, TP, Maguire, AR, McCarthy, F; (2005) 'Phytosterol, Tocopherol and Squalene Content of Five Edible Nuts (Brazil, Pecan, Pine, Pistachio, Cashew)'. :41-41 [Details] | |
| (2005) | 'Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives' McCarthy, FO,Chopra, J,Ford, A,Hogan, SA,Kerry, JP,O'Brien, NM,Ryan, E,Maguire, AR; (2005) 'Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives'. Organic and Biomolecular Chemistry, 3 :3059-3065 [DOI] [Details] | |
| (2004) | 'Enantioselective synthesis of non-natural amino acids using phenylalanine dehydrogenases modified by site-directed mutagenesis' Busca P, Paradisi F, Moynihan E, Maguire AR, Engel PC; (2004) 'Enantioselective synthesis of non-natural amino acids using phenylalanine dehydrogenases modified by site-directed mutagenesis'. Organic and Biomolecular Chemistry, 2 (18):2684-2691 [DOI] [Details] | |
| (2003) | 'Comparison of the cytotoxic effects of beta-sitosterol oxides and a cholesterol oxide, 7 beta-hydroxycholesterol, in cultured mammalian cells' Maguire, L,Konoplyannikov, M,Ford, A,Maguire, AR,O'Brien, NM (2003) 'Comparison of the cytotoxic effects of beta-sitosterol oxides and a cholesterol oxide, 7 beta-hydroxycholesterol, in cultured mammalian cells'. British Journal of Nutrition, 90 :767-775 [DOI] [Details] | |
| (2003) | 'Chemoenzymatic methods in the asymmetric synthesis of a-diazosulfoxides' Maguire, A.R.; Collins, S.G.; Ford, A.; (2003) 'Chemoenzymatic methods in the asymmetric synthesis of a-diazosulfoxides'. ARKIVOC, Part (vii) :96-109 [Details] | |
| (2002) | 'New methods for the synthesis of N-benzoylated uridine and thymidine derivatives; a convenient method for N-debenzoylation' Maguire, AR,Hladezuk, I,Ford, A; (2002) 'New methods for the synthesis of N-benzoylated uridine and thymidine derivatives; a convenient method for N-debenzoylation'. Carbohydrate Research, 337 :369-372 [DOI] [Details] | |
| (2002) | 'Structure-Activity Relationship of Indomethacin Analogues for MRP-1, COX-1 and COX-2 Inhibition; Identification of Novel Chemotherapeutic Drug Resistance Modulators' S. Touhey, R. O'Connor, S. J. Plunkett, A. R. Maguire and M. Clynes.; (2002) 'Structure-Activity Relationship of Indomethacin Analogues for MRP-1, COX-1 and COX-2 Inhibition; Identification of Novel Chemotherapeutic Drug Resistance Modulators'. European Journal of Cancer, 38 (12):1661-1670 [Details] | |
| (2001) | 'Synthesis of Indomethacin Analogues for Evaluation as Moderators of MRP Activity' A.R. Maguire, S.J. Plunkett, S. Papot, M. Clynes, R. O’Connor and S. Touhey. ; (2001) 'Synthesis of Indomethacin Analogues for Evaluation as Moderators of MRP Activity'. Bio-Organic and Medicinal Chemistry Letters, 9 (*):745-762 [Details] | |
| (2001) | 'Dynamic equilibria in the products of intramolecular Buchner additions of diazoketones to aryl rings bearing methoxy substituents' Maguire, AR,O'Leary, P,Harrington, F,Lawrence, SE,Blake, AJ; (2001) 'Dynamic equilibria in the products of intramolecular Buchner additions of diazoketones to aryl rings bearing methoxy substituents'. The Journal of Organic Chemistry, 66 :7166-7177 [Details] | |
| (2001) | 'Enantioselective Synthesis of Sulindac' A.R. Maguire, S. Papot, A. Ford, S. Touhey, R. O'Connor, and M. Clynes.; (2001) 'Enantioselective Synthesis of Sulindac'. Synlett, :41-44 [Details] | |
| (2001) | '4-ethynyl-1,2-methylenedioxybenzene at 150 K' Lawrence, SE,Blake, AJ,Maguire, AR,Moynihan, JA; (2001) '4-ethynyl-1,2-methylenedioxybenzene at 150 K'. Acta Crystallographica. Section C, Crystal Structure Communications, 57 :412-413 [Details] | |
| (2000) | 'Matrix isolation and photochemistry of alpha-diazo sulfoxides: Formation of alpha-oxo sulfine as an intermediate' Sander, W,Strehl, A,Maguire, AR,Collins, S,Kelleher, PG; (2000) 'Matrix isolation and photochemistry of alpha-diazo sulfoxides: Formation of alpha-oxo sulfine as an intermediate'. European Journal of Organic Chemistry, :3329-3335 [Details] | |
| (1999) | 'Dynamic Kinetic Resolution in the Baker's Yeast Mediated Reduction of 2-Benzenesulfonylcycloalkanones ' A.R. Maguire and N. O'Riordan.; (1999) 'Dynamic Kinetic Resolution in the Baker's Yeast Mediated Reduction of 2-Benzenesulfonylcycloalkanones '. Tetrahedron Letters, 40 (*):9285-9288 [Details] | |
| (1998) | 'Rhodium Catalysed Decomposition of alpha-diazosulfoxides formation of alpha-oxo sulfines as intermediates' Maguire, A.R.; Kelleher, P.G.; Lawrence, S.E.; (1998) 'Rhodium Catalysed Decomposition of alpha-diazosulfoxides formation of alpha-oxo sulfines as intermediates'. Tetrahedron Letters, 39 (22):3849-3852 [Details] | |
| (1998) | 'Stereocontrol in the Intramolecular Buchner Reaction of Diazoketones' A.R. Maguire, N.R. Buckley, P. O'Leary, and G. Ferguson.; (1998) 'Stereocontrol in the Intramolecular Buchner Reaction of Diazoketones'. Journal of The Chemical Society - Section D: Chemical Communication, Perkin Trans. 1 :4077-4091 [Details] | |
| (1998) | 'Transition Metal Catalysts and Immobilised Biocatalysts in Enantioselective Synthesis “Supported Reagents and Catalysts in Chemistry”, ed' A.R. Maguire and L.L. Kelleher. ed. B.K. Hodnett, A.P. Kybett, J.H. Clark, K. Smith.; (1998) 'Transition Metal Catalysts and Immobilised Biocatalysts in Enantioselective Synthesis “Supported Reagents and Catalysts in Chemistry”, ed'. Royal Society of Chemistry, Cambridge (*):116-121 [Details] | |
| (1998) | 'Synthesis of alpha-diazo-beta-oxo sulfoxides' Maguire, AR,Kelleher, PG,Ferguson, G,Gallagher, JF; (1998) 'Synthesis of alpha-diazo-beta-oxo sulfoxides'.Tetrahedron, 39 :2819-2822 [Details] | |
| (1997) | 'Asymmetric Reduction of 1-Methylsulfonylalkan-2-Ones With Baker's Yeast [B291]' Maguire, A. R.; Lowney, D. G; (1997) 'Asymmetric Reduction of 1-Methylsulfonylalkan-2-Ones With Baker's Yeast [B291]'. Journal of The Chemical Society. Perkin Transactions I, :235-238 [Details] | |
| (1997) | 'Enantioselective Introduction of a Benzenesulfonylmethyl Substituent at an Unactivated Carbon Atom Via Chemoenzymatic Methods [B293]' Maguire, A. R.; Kelleher, L. L.; (1997) 'Enantioselective Introduction of a Benzenesulfonylmethyl Substituent at an Unactivated Carbon Atom Via Chemoenzymatic Methods [B293]'. Tetrahedron Letters, 38 :7459-7462 [Details] | |
| (1997) | 'Selective Manganese-Mediated Transformations Using the Combination: KMnO_4/Me_3SiCl [B292]' Marko, I. E.; Richardson, P. R.; Bailey, M.; Maguire, A. R.; Coughlan, N.; (1997) 'Selective Manganese-Mediated Transformations Using the Combination: KMnO_4/Me_3SiCl [B292]'. Tetrahedron Letters, 38 :2339-2342 [Details] | |
| (1996) | 'Excellent stereocontrol in intramolecular Buchner cyclisations and subsequent cycloadditions; Stereospecific construction of polycyclic systems' Maguire, AR,Buckley, NR,O'Leary, P,Ferguson, G; (1996) 'Excellent stereocontrol in intramolecular Buchner cyclisations and subsequent cycloadditions; Stereospecific construction of polycyclic systems'. Chemical Communications, :2595-2596 [Details] | |
| (1996) | 'Efficient Kinetic Resolution of 2-Benzenesulfonylcyclopentanone Derivatives [B289]' Maguire, A. R.; Kelleher, L. L.; Ferguson, G.; (1996) 'Efficient Kinetic Resolution of 2-Benzenesulfonylcyclopentanone Derivatives [B289]'. Journal of Molecular Catalysis B: Enzymatic, 1 :115-126[Details] | |
| (1995) | 'Single Step Stereospecific Transformation of 2-Phenylthio Secondary Amides into (Z)-3-Chloro-_2Phenylthio Acrylamides [B287]' Maguire, A. R.; Murphy, M. E.; Schaeffer, M.; Ferguson, G.; (1995) 'Single Step Stereospecific Transformation of 2-Phenylthio Secondary Amides into (Z)-3-Chloro-_2Phenylthio Acrylamides [B287]'. Tetrahedron Letters, 36 :467-470 [Details] | |
| (1993) | 'Synthetic Approaches Towards Nucleocidin and Selected Analogues; Anti-HIV Activity in 4'-Fluorinated Nucleoside Derivatives [B285]' Maguire, A. R.; Meng, W.; Roberts, S. M.; Willetts, A. J.; (1993) 'Synthetic Approaches Towards Nucleocidin and Selected Analogues; Anti-HIV Activity in 4'-Fluorinated Nucleoside Derivatives [B285]'. Journal of The Chemical Society. Perkin Transactions I, :1795-1808 [Details] | |
| (1993) | 'Structure of 1-(3-Butynyl)Pyridinium {p}-Toluenesulfonate [B286]' Ferguson, G.; Gallagher, J. F.; Maguire, A. R.; Spalding, T. R.; Peters, G.; Morris, J. R.; (1993) 'Structure of 1-(3-Butynyl)Pyridinium {p}-Toluenesulfonate [B286]'. Acta Crystallographica, Section C, :2160-2162 [Details] | |
| (1990) | 'Organic Synthesis with alpha-Chloro Sulphides. Preparation of Aromatic gamma-Lactones from Phenols and alpha-Chloro Sulphide Carboxylates' M. Kennedy, M.A. McKervey, A.R. Maguire, and S. Naughton.; (1990) 'Organic Synthesis with alpha-Chloro Sulphides. Preparation of Aromatic gamma-Lactones from Phenols and alpha-Chloro Sulphide Carboxylates'.Journal of The Chemical Society, Perkin Trans. I :1041-1045 [Details] | |
| (1990) | 'The Intramolecular Buchner Reaction of Aryl Diazoketones. Substituent Effects and Scope in Synthesis' M. Kennedy, M.A. McKervey, A.R. Maguire, S.M. Tuladhar, and M.F. Twohig.; (1990) 'The Intramolecular Buchner Reaction of Aryl Diazoketones. Substituent Effects and Scope in Synthesis'. J. Chem. Soc, Perkin Trans. I :1047-1054 [Details] | |
| (1990) | 'Asymmetric Synthesis in Carbon-Carbon Bond Forming Reactions of alpha-Diazoketones catalysed by Homochiral Rhodium(II) Carboxylates' M. Kennedy, M.A. McKervey, A.R. Maguire, and G.H.P. Roos.; (1990) 'Asymmetric Synthesis in Carbon-Carbon Bond Forming Reactions of alpha-Diazoketones catalysed by Homochiral Rhodium(II) Carboxylates'. Journal of The Chemical Society, Chem. Commun :361-362 [Details] | |
| (1986) | 'Organic-Synthesis with alpha-Chlorosulfides - Conversion of Phenol into gamma-Lactones using Methyl-2-Chloro-2-(Alkyl or Arylthio)Carboxylates' KENNEDY, M,MAGUIRE, AR,MCKERVEY, MA; (1986) 'Organic-Synthesis with alpha-Chlorosulfides - Conversion of Phenol into gamma-Lactones using Methyl-2-Chloro-2-(Alkyl or Arylthio)Carboxylates'. Tetrahedron, 27 :761-764[Details] |
Org. Process Res. Dev., Article ASAP
DOI: 10.1021/op5003825
There is a growing trend in Ireland toward greater collaboration between academia and the pharmaceutical industry. This is an activity encouraged at a national policy level as a means of providing researchers from academic institutions the opportunity to gain important first-hand experience in a commercial research environment, while also providing industry access to expertise and resources to develop new and improved processes for timely medicines. The participating company benefits in terms of its growth, the evolution of its strategic research and development, and the creation of new knowledge that it can use to generate commercial advantage. The research institute benefits in terms of developing skill sets, intellectual property, and publications, in addition to access to identified current industry challenges. A case study is provided describing the collaborative partnership between a synthetic chemistry research team at University College Cork (UCC) and Eli Lilly and Company.
CORK IRELAND
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