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Tuesday, 21 April 2015

Brindar Sandhu

Brindar Sandhu at the UCB Amgen Scholars Poster Session ...


Brindar Sandhu

Email: brindar.sandhu@emory.edu https://www.linkedin.com/pub/brindar-sandhu/29/a79/a42 http://www.researchgate.net/profile/Brindar_Sandhu


University of Michigan

B.S.E., Biomedical Engineering
2006 – 2010
Activities and Societies: Asha for Education, SWE, BMES


Graduate Student

Emory University
August 2011 – Present (3 years 9 months)Atlanta, GA
Genetics & Molecular Biology Ph.D. program
Dissertation topic: "Aminoglycoside phosphotransferases: Models for Enzyme Evolution" Rotation project, lab of Justin Gallivan, Ph.D.: "Creating a Theophylline-binding OFF-Riboswitch" Attempted to create a riboswitch utilizing an aptamer that changed secondary structure upon binding of the small molecule theophylline in the 5’ UTR, such that downstream translation of a reporter gene is inhibited Rotation project, lab of David Lynn, Ph.D.: "Selecting for Amyloid Production to Epigenetically Regulate Plasmid Copy Number" Developed a proposal based on the RepA plasmid replication protein, specifically a mutant version that induces the formation of amyloid, to regulate plasmid copy number through antibiotic selection and amyloid production Rotation project, lab of Ichiro Matsumura, Ph.D.: "Using Bacteria as a Sensor" Attempted to engineer the metal-reducing bacterium, Shewanella oneidensis, to act as a gating detection device to, upon addition of lactose, sense the small molecule, theophylline, and upon binding, transcribe and translate the lacY and lacZ genes and emit electrons that can be detected using a voltmeter

Social co-chair, Graduate Student Council

Emory University
August 2013 – Present (1 year 9 months)
Help plan, set-up, and execute mixers for Laney graduate students (4 per year) Facilitate cab reimbursement program with the Graduate Student Government Association (GSGA) Serve as a Laney representative to GSGA

President, Graduate Students in Genetics

Emory University
November 2013 – August 2014 (10 months)
Co-founded and currently aid in running the extracurricular group Graduate Students in Genetics, or GSIG. We hold monthly networking mixers in order to facilitate networking for those interested in genetics within the graduate school. GSIG is a chartered group through the Laney Graduate School's Graduate Student Council.

GMB Student Representative

Emory University
August 2013 – July 2014 (1 year)
Function as a liaison between faculty and students within the GMB program Serve on the recruitment and the retreat committee to help plan, set up, and run recruitment for incoming class as well as the annual program retreat

Teaching Assistant - BIOL 264: Genetics: A Human Perspective

Emory University
January 2014 – May 2014 (5 months)
Facilitate weekly class discussions
Graded three exams per semester along with another TA and the instructor.

Teaching Assistant - BIOL 370: Introduction to Microbiology

Emory University
August 2012 – December 2012 (5 months)Atlanta, GA
Graded weekly homework assignments and three exams throughout the semester for an undergraduate course of 130 students
Held review sessions in preparation for the three exams Held weekly office hours for assistance with homework assignments

Postbaccalaureate Research Fellow

National Institutes of Health
June 2010 – June 2011 (1 year 1 month)Bethesda, MD
National Institute of Diabetes and Digestive and Kidney Diseases Genetics of Simple Eukaryotes Section Laboratory of Biochemistry and Genetics
Ran a screen for URE2 mutations that prevent the Hsp40 Ydj1 from curing Ure2delta yeast cells of the [URE3] prion to deduce essential domain interactions for prion propagation in Saccharomyces cerevisiae Tested known mutations to the Hsp40 Sis1 that cause changes to the [PSI+] prion for phenotypic changes to the [URE3] prion in Saccharomyces cerevisiae

Grader, BiomedE 321: Bioreaction Engineering & Design

University of Michigan
January 2010 – April 2010 (4 months)Ann Arbor, MI
Department of Biomedical Engineering
Worked with the instructional aide, graduate student instructor, and the professors to grade homework assignments, exams, and regrade requests, return them to the students, and upload grades online

Undergraduate Research Assistant

University of Michigan Health System
May 2008 – April 2010 (2 years)Ann Arbor, MI
Urology Department
Project 1 (Sept 2009 – Apr 2010): “The Roles of Soluble E-Cadherin and EGFR in Prostate Cancer” Used timed experiments, immunoprecipitations, and western blots to analyze interaction of soluble E-Cadherin and EGFR in prostate cancer cell lines Project 2 (Jun 2008 – Apr 2009): “The Role of ADAM15 in the Metastatic Progression of Prostate Cancer” Examined the interaction of ADAM15 (A Disintegrin And Metalloproteinase) and EGFR family members and the AKT signaling pathway in LNCaP cells using western blots and immunoflourescence Presented results in oral presentation at conclusion of program Wrote final reports at the end of each semester summarizing data and conclusions Co-author on abstract submitted to American Association of Cancer Research: Advances in Prostate Cancer Research National Conference: “Activation of the Disintegrin Protease ADAM15 Leads to Cleavage of E-cadherin and Enhanced Signaling in Prostate Cancer Cells”

Amgen Scholar

University of California, Berkeley
June 2009 – August 2009 (3 months)Berkeley, CA
Department of Bioengineering
Project: “Induced Control of MLCK-Dependent Mechanobiology in Human Glioma Cells” Performed 2-D collagen gel, 3-D gel contraction, immunoflourescence and cell migration assays to demonstrate changes in tumor invasiveness properties in human glioma cells as myosin light chain kinase (MLCK) activity was varied using a tetracycline-off promoter construct Presented results in poster and oral presentations at conclusion of program Discussed research with other scholars and professional scientists at 2009 Amgen Scholars U.S. Symposium at UCLA (July 2009)

Summer Research Intern

University of Kansas
May 2007 – July 2007 (3 months)Lawrence, KS
Research Experience for Undergraduates Department of Chemical and Petroleum Engineering
Project: “Subcritical CO2-melded Poly(D,L-lactide-co-glycolide) Microsphere-based Tissue Scaffolds for Cartilage Tissue Engineering” Seeded novel tissue scaffolds with chondrocyte cells to determine feasibility for future osteochondral tissue engineering Tested strength of microsphere-based scaffolds with uniaxial compression tests Tested cell viability and cartilage formation with histological and immunohistochemical assays Presented results in the form of a poster at a university-wide poster symposium

Honors & Awards

NIH GMB Training Grant

Emory Genetics & Molecular Biology Ph.D. Program
August 2011


Emory University

  • Introduction to prokaryotic molecular genetics
  • Genetics of progenitor and stem cells
  • Eukaryotic chromosome organization & function
  • Model genetic systems
  • Ethical conduct in research
  • Hypothesis design & scientific writing
  • Introductory graduate seminar

Limin Wang, Milind Singh, Mihael Lazebnik, Michael Detamore, and Liang Zhao. Front Row: Ivy Tran, Brindar Sandhu, Jeannie Salash, and Jordan Christian.

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