DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair,With death on the horizon, This will not stop me, Gods call only..........
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contributio
n

Thursday, 16 April 2015

Dr. Akanksha Gupta


Dr.Akanksha Gupta

Dr. Akanksha Gupta

Medicinal Chemist with industrial and Post doc experience


aks25gupta (Google Talk)


Summary
A professional and progressive researcher through continuous learning and implementing new ideas through my dedication, hard work. Skilled researcher with doctorate in medicinal and organic chemistry. Strong background in data interpretation by modern spectroscopic methods, drug designing and synthetic organic chemistry. Good written, oral communication and computational skills. Always ready to assignment on teaching and/or research.
Done Ph.D. (thesis entitled "Design and Synthesis of Novel Nuclear Receptor Modulator”) in Medicinal Chemistry from Central Drug Research Institute, Lucknow India. she have also three years industrial experience. During the course of  Ph.D program and job at industry, worked on various aspects of Synthetic and Medicinal Chemistry. She has also done post doctorate with Dr. Julio Camarero in university of southern California.

Her research work based on the design, synthesis and biological study of novel scaffolds for the treatment of osteoporosis and breast cancer disease. In order to obtain a new potential lead, our drug discovery effort were focused toward identifying a potential SERMs,  have designed and synthesized several novel synthetic scaffolds and evaluated them for their anti-osteoporotic, anti-implantation and anti-proliferative activity. she explored myself with the interface of Organic Chemistry and Biology.
In this process, She synthesized series of carbocyclic and heterocyclic scaffolds.

After submission of her thesis, she joined pharmaceutical industry and worked on the design and multiple step synthesis of biologically active molecules. There she also worked on to develop new synthetic methods with good yield. During her stay in Industry, she worked on various metal halogen exchange and C-H activation reactions and she developed a huge interest in metal exchange chemistry. Currently she is residing in Pleasanton, CA

Dr. Akanksha Gupta, Ph.D. (Medicinal & Process Chemistry) Mobile+1 (510)-736-9076 (cell)
 

Experience




PG diploma in Intellectual property rights

Indira Gandhi National Open University (IGNOU)
October 2012 – Present (2 years 7 months)Noida



Post Doctoral Reasearch Fellow

University of Southern California
September 2011 – September 2012 (1 year 1 month)California, CA
Research on Peptide chemistry



Research Scientist

Teva Pharmaceutical Industries Ltd.
June 2010 – August 2011 (1 year 3 months)Greater Noida, INDIA
Process development of API and impuritiy profiling: Design syntheitic route, synthesis, characterization and purification of impurities in various APIs like Tadalafil, Valsartan, Pregabalin, Gemfibrozil, Atorvastatin, Derifenacine etc. Identification, quantification, and control of impurities in the active pharmaceutical drug substance. Identification of impurity by various chromatographic as well as spectroscopic methods such as HPLC, UPLC, LCMS, GCMS, NMR, IR and purification by crystallization, Column and combi-flash tequnique



Senior Research Scientist

AMRI
April 2009 – May 2010 (1 year 2 months)Hyderabad Area, India
Design novel synthetic routes to target molecules, planning and executing projects independently and to demonstrate expertise in both the theoretical and practical aspects of organic chemistry.



Senior Research Associate

AMRI
May 2008 – April 2009 (1 year)Hyderabad Area, India
Responsible to finish project on time with high quality, communication with client and co-ordination with chemists, preparation of update and final reports. Handled catalogue compounds and also did multi kilo scale project. Prepared 6- 8 kg compound



Research Scholar

Central Drug Research Institute, Lucknow Edit Ph.D, Medicinal Organic Chemistry
August 2003 – May 2008 (4 years 10 months)Lucknow Area, India

Education




Post Doctoral Reasearch Fellow

University of Southern California
September 2011 – September 2012 (1 year 1 month)California, CA
Research on Peptide chemistry



PG diploma in Intellectual property rights

Indira Gandhi National Open University (IGNOU)
October 2012 – Present (2 years 7 months)Noida



Central Drug Research Institute, Lucknow

Ph.D, Medicinal Organic Chemistry
2003 – 2008
Research work focused on design and synthesis of novel scaffolds which act as nuclear receptor modulator and used for the prevention and treatment of various high profile human diseases such as breast cancer, endometrial cancer, osteoporosis, diabetes and in fertility regulation etc. Among the nuclear hormone receptors super gene family we are most interested in estrogen receptor (ER) and also in peroxisome-proliferators-activated receptor for anti-diabetic activity. As estrogen action is also associated with many health problems in women. In order to use estrogen receptor modulator in its full length, we have designed some selective estrogen receptor modulator (SERMs). The aim of the present dissertation is synthesis and identification of some novel scaffolds with selective agonistic as well as antagonistic activity in desired tissue profiles and further the biological evaluation of these scaffolds in vitro cell line model and in vivo animal models for predictive clinical utility.

M.S., Organic Chemistry (2003, 77.3%) Lucknow University, Lucknow (U. P.), India

B.S., Chemistry, Zollogy and Botany (2000,74.4%) Lucknow University, Lucknow, (U. P.), India


Publications 

· “Amino acid catalyzed thio-Michael addition reactions” Atul Kumar, Akanksha. Tetrahedron, 2007, 63, 11086-11092. 

· “Zirconium chloride catalyzed efficient synthesis of 1, 3-diaryl-2-propenones in solvent free conditions via aldol condensation” Atul Kumar, Akanksha. Journal of Molecular Catalysis A: Chemical, 2007, 274, 212-216. 

· “HbA/H2O2: an efficient biomimetic catalytic system for the oxidation of sulfides to sulfoxides” Atul Kumar, Akanksha. Tetrahedron Letters, 2007, 48, 7857-7860. 

· “An efficient one way selective oxidative cleavage of oximes using hypervalent iodine” Atul Kumar, Pervez Ahmad, Akanksha and Ram Awatar Murya. Combinatorial Chemistry and high throughput screening, 2005, 8, 445-447. 

· “Multicomponent, solvent-free synthesis of β-aryl-β-mercapto ketones using zirconium chloride as a catalyst” Atul Kumar, Akanksha. Tetrahedron Letters, 2007, 48, 8730. 

· “Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents” Atul Kumar, Vishwa Deepak Tripathi, Promod Kumar, Lalit Prakash Gupta, Akanksha, Ritu Trivedi, Hemant Bid, V.L. Nayak, Jawed A. Siddiqui, Bandana Chakravarti, Ruchi Saxena, Anila Dwivedi, M.I. Siddiquee, U. Siddiqui, Rituraj Konwar, Naibedya Chattopadhyay. Bioorganic & Medicinal Chemistry, 2011,19 5409.

 · Design and Synthesis of novel benzisoxazole motif with basic amino anti-estrogenic side chain as ER-receptor subtype ligands selective. Bioorganic and Medicinal Chemistry letter.Atul Kumar, Akanksha Communicated. Attented/Paper Presented in International 

Conferences: 
· Attended “Indian Science Congress” from Lucknow University, Lucknow, India, 3-7 January 2002. · Attended the joint International Conference on “Current Trends in Drug Discovery Research” Central Drug Research Institute, Lucknow, India, 17-21 Febuary-2004. · IInd Inter. Symp. on Current Trends in Drug Discovery Research, Central Drug Research Institute, Lucknow, India, 17-22 Febuary-2007. Presented a poster on in the “Qunoline amide as a antithrombotic agent.” · 10th National Symposium in Chemistry, Indian Institute of Science, Bangalore, 1 Febuary-2008. Presented a poster on “Human hemoglobin an efficient biomimetic catalytic system for the oxidation of sulfides to sulfoxides.”


Selected Abstracts · “Qunoline amide as a antithrombotic agent.” Atul Kumar, Akanksha. 2nd Inter. Symp. on Curr.Trends in Drug Discovery Res. (CTDDR-2006),organized by CDRI (CSIR), Lucknow, India, Feb 2006. · “Human hemoglobin an efficient biomimetic catalytic system for the oxidation of sulfides to sulfoxides.” Atul Kumar, Akanksha.10th National Symposium in Chemistry Division of Chemical Sciences organized by Indian Institute of Science, Bangalore.


Selected Oral presentation · “Artificial Sweetners” (Jan 2003) in University of Lucknow, Lucknow · “Design and Synthesis of Novel Nuclear Receptor Modulator” (Jan 2008) at Central Drug Research Institute, Lucknow-226001, India. · Diels Alder Reaction” (April 2006) at Central Drug Research Institute, Lucknow-226001, India.
  1. Map of pleasanton california
The Altamont Commuter Express train leaving Pleasanton station in the afternoon



Muirwood Park, Pleasanton


 

No comments:

Post a Comment