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Wednesday, 9 March 2016

Chandrakant Ramkrishna Malwade

Chandrakant Malwade

Abstract Image
Crystallization is an inevitable step in the purification of artemisinin either from the plantArtemisia annua or from reaction mixtures of semisynthetically produced artemisinin.
Rational design of crystallization process requires knowledge about the solid–liquid equilibrium in a given solvent system and effect of impurities on it.
In the present work, a crystallization process was designed to purify artemisinin from fractions of a flash chromatography column effluent collected after injecting extracts of Artemisia annua leaves.
The fractions from chromatography containing artemisinin were combined together into one fraction, and the impurities present in this fraction were identified.
The solubility of artemisinin in the mobile phase used for chromatography, i.e.,n-hexane–ethyl acetate mixture of varying compositions, was measured at 25, 15, and 5 °C, respectively. The collective effect of impurities present in the combined fraction on the solid–liquid equilibrium of artemisinin was evaluated by measuring the solubility of artemisinin in the combined fraction at same temperatures. The results show that the impurities present in the combined fraction increase the solubility of artemisinin.
Finally, the crystallization of artemisinin from the combined fraction designed on the basis of artemisinin solubility data was carried out in two steps by adding an antisolvent and cooling crystallization.
The yield of artemisinin obtained in the process was 50%, and it was found that the impurities present in the combined fraction at a given concentration do not affect the crystallization of artemisinin.

Figure 2. Chemical structure of artemisinin (1) and impurities [artemisitene (2), dihydroartemisinic acid (3), artemisinic acid (4), arteannuin B (5), and coumarin (6)] found in the combined fraction.

Crystallization of Artemisinin from Chromatography Fractions ofArtemisia annua Extract

 Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, 39106 Magdeburg, Germany
§ Institute of Process Engineering, Otto von Guericke University, 39106 Magdeburg, Germany
Org. Process Res. Dev., Article ASAP
DOI: 10.1021/acs.oprd.5b00399
Publication Date (Web): February 09, 2016
Copyright © 2016 American Chemical Society
*E-mail: crm@kbm.sdu.dk; phone: 0045 65508669.

Conceptual process synthesis for recovery of natural products from plants: a case study of artemisinin from Artemisia annua
CR Malwade, H Qu, BG Rong, LP Christensen
Industrial & Engineering Chemistry Research 52 (22), 7157-7169
Ternary solubility phase diagrams of mandelic acid and N-methylephedrine in chiral solvents with different carbon chain lengths
SK Tulashie, H Lorenz, CR Malwade, A Seidel-Morgenstern
Crystal Growth & Design 10 (9), 4023-4029
Purification of artemisinin from quercetin by anti-solvent crystallization
CR Malwade, H Qu, BG Rong, LP Christensen
Frontiers of Chemical Science and Engineering 7 (1), 72-78
Evaporative crystallization of carbamazepine from different organic solvents
CR Malwade, H Qu, BG Rong, LP Christensen
Biwic 2013: Proceedings of the 20 th Bremen International Workshop on ...
Anti-solvent crystallization of artemisinin and the effect of a natural co-existing impurity
CR Malwade, H Qu, BG Rong, LP Christensen
Biwic 2012: Proceedings of the 19 th Bremen International Workshop on 


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