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Tuesday 12 April 2016

Abdel Omri

Abdel Omri

Laurentian University
Canada
Abdel Omri obtained his PhD from Université de Montréal in 1996. After completing postdoctoral fellowships at McGill University and the University of Toronto (1996-1998), he spent more than 2 years as Research associate at NRC (institute of biological sciences in Ottawa) from 1998 to 2000. He is currently Full Professor in the Department of Chemistry and Biochemistry with a cross appointment to the Department of Biology, the Biomolecular Sciences PhD Programme, School of Rural and Northern Health PhD Programme. His research interests are focused on Lipid-based drug and vaccine delivery systems. His laboratory employs a multi-disciplinary approach to addressing the antimicrobial resistance to gram negative bacteria in cystic fibrosis patients and in medical devices implants. He is also involved in the education of undergraduate and graduate students through the coordination of several calendar courses in biochemistry, pharmacology and toxicology and pharmaceutical technology. In addition to research, He is actively involved in the research training of both undergraduate and graduate students. He has served in administrative capacities in several international scientific societies. He has published over 50 peer-reviewed research articles over his career on various aspects of drug delivery and targeting in addition to several published book chapters and books (2). He has served on a number of Editorial Boards and Granting Agencies in Canada and abroad. He also has 2 patents.

Research Interest

Biochemistry; Pharmacology; Toxicology; Pharmaceutical technology; Lipid-based drug and vaccine delivery systems.

Abdelwahab Omri

Full Professor

Chemistry and Biochemistry
Science, Engineering and Architecture

S-416, Science Building
Sudbury Campus

705.675.1151 ext 2190

aomri@laurentian.ca

https://laurentian.academia.edu/AbdelOmri

https://www.linkedin.com/in/abdel-omri-19842811

Biography

Dr. Omri obtained his Ph.D. degree from the Université de Montréal, Canada, in 1995. After completing postdoctoral fellowships at McGill University and the University of Toronto (1996–1998), he spent more than 2 years as Research Associate at NRC (Institute of Biological Sciences in Ottawa) from 1998 to 2000. Dr. Omri is currently a Full Professor at the Department of Chemistry and Biochemistry with a cross appointment to the Department of Biology, the Biomolecular Sciences Ph.D. Program, School of Rural and Northern Health Ph.D. Program. His research interests are focused on lipid-based drug and vaccine delivery systems. His laboratory employs a multidisciplinary approach to addressing the antimicrobial resistance to gram negative bacteria in cystic fibrosis patients and in medical devices implants. Dr. Omri is also involved in the education of undergraduate and graduate students through the coordination of several calendar courses in biochemistry, pharmacology and toxicology, and pharmaceutical technology. In addition to research, Dr. Omri is actively involved in the research training of both undergraduate and graduate students. Dr. Omri has served in administrative capacities in several international scientific societies. He has published over 60 peer-reviewed research articles over his career on various aspects of drug delivery and targeting in addition to several published book chapters and books (2). He has served on a number of editorial boards and granting agencies in Canada and abroad. Dr. Omri has 2 patents.

Education

Pharm B
MSc
PhD

Abdel Omri, Ph.D.

Northern Ontario School of Medicine, East Campus
935 Ramsey Lake Road
Sudbury ON Canada P3E 2C6
Email: aomri@nosm.ca

Current Position

Professor, Chemistry/Biochemistry
Cross appointed to Northern Ontario School of Medicine, Medical Sciences Division
Cross appointed to Biology, Laurentian University:
Faculty member: Biomolecular Sciences PhD program, Laurentian University
Faculty member: IRNH PhD program, School of Rural & Northern Health Laurentian University

Education and Training

Ph.D. Pharmacology (Faculty of Medicine). University of Montreal, 1996
M.Sc. Pharmacology (Faculty of Medicine). University of Montreal, 1992
B.Sc. Pharmacy, University of Baghdad (Baghdad), 1983

Research Investigations

My current interests include:

Liposomal delivery of antisense oligonucleotides. Effect on P-glycoprotein function in multidrug resistant cells in vitro and in vivo studies. Cationic liposome formulations are used to promote the penetration of antisense oligonucleotides into the cell membrane and protect them from enzymatic degradation (nucleases).
Liposomal delivery of antimicrobial agents towards resistant bacterial pathogens: pulmonary and systemic infections. Construction of liposomes with high encapsulation efficiency, favorable antimicrobial release profile and enhanced bactericidal activity, to overcome the problem of bacterial resistance caused by low permeability of the bacterial cell envelope and by production of antimicrobial-inactivating enzymes.
Liposomal formulations of drugs and vaccine for oral delivery. Liposomes are used to protect the encapsulated agents from the harsh gastrointestinal milieu (low pH, phospholipases, and bile salts) and to enhance their absorption to the systemic circulation and to increase the efficacy of these agents while minimizing their frequency of administration. Special liposomal formulation will be prepared, characterized and assayed for their efficacy in vitro and in animal models.

Membership and Contributions in Professional Organizations

American Society for Microbiology
American Society of Pharmacology and Experimental Therapeutics
Pharmacological Society of Canada
Canadian Society of Pharmaceutical Sciences
Ordre des Pharmaciens de Tunisie

Selected Publications

Shweta Gupta, Rajesh Kesarla Abdelwahab Omri. Formulation strategies to improve the bioavailabilty of poorly absorbed drugs with special emphasis on self-emulsifying systems ISRN Pharmaceutics, 2013. In press
Moayad Alhariri, Ali O. Azghani, Abdelwahab Omri. Liposomal antibiotics for infectious diseases. Expert Opinion on Drug Delivery. 2013 Nov;10 (11): 1515-32
Adam Bignucolo, Varun P. Appanna, Sean C. Thomas, Christopher Auger, Sungwon Han, Abdelwahab Omri, Vasu D. Appanna. Hydrogen peroxide stress provokes a metabolic reprogramming in P. fluorescens: Enhanced production of pyruvate. Journal of Biotechnology. 2013 Sept; 167 (3): 309–315
Mai Alhajlan, Moayad Alhariri, Abdelwahab Omri. Liposomal Clarithromycin: Effectiveness, Safety and Modulation of Pseudomonas aeruginosa Virulence Factors. Antimicrobial Agents and Chemotherapy. 2013 Jun; 57(6):2694-704.
Alhariri M, Omri A. Efficacy of liposomal bismuth-ethanedithiol-loaded tobramycin after intratracheal administration in rats with pulmonary Pseudomonas aeruginosa infection. Antimicrobial Agents and Chemotherapy. 2013 Jan; 57(1): 569-78.
Linette Sande, Marisel Sanchez, Joy Montes, Andrea J. Wolf, Margie A. Morgan, Abdelwahab Omri, George Y. Liu.Liposomal Encapsulation of Vancomycin Improves Killing of Methicillin-Resistant Staphylococcus aureus in a Murine Infection Model. Journal of Antimicrobial Chemotherapy. 2012 Sep;67(9): 2191-4.

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