Natalie Flanagan
Postbaccalaureate Fellow – Cancer Research Training Award (CRTA) at National Cancer Institute (NCI)
https://www.facebook.com/natalie.flanagan.3386/about
CRTA Postbaccalaureate Fellow at National Cancer Institute at FrederickPast: University of Maryland and Pfizer
Studied Cell Biology and Genetics at University of Maryland, College ParkPast: Ledyard High School
Lives in Rockville, Maryland
In a relationship with Luke SkalaIn a relationship since November 17, 2012
Experience
Postbaccalaureate Fellow – Cancer Research Training Award (CRTA)
National Cancer Institute (NCI)
Organic Chemistry Lab TA
University of Maryland
– Ran on section of the Organic Chemistry I laboratory course for two semesters
– Worked with students in a laboratory setting and office hours to help them understand course materials and experimental procedures
– Worked with professors and other TAs to help develop and grade examinations
– Worked with students in a laboratory setting and office hours to help them understand course materials and experimental procedures
– Worked with professors and other TAs to help develop and grade examinations
Summer Intern
Pfizer
– Used protein crystallization to research ligand binding in a protein kinase system
– Learned a variety of laboratory techniques, including: expression and purification of proteins, and various protein crystallization techniques
– Gained a basic knowledge for how to interpret electron density maps used in three-dimensional protein structure determination
– Presented my research project at an internal poster presentation
– Learned a variety of laboratory techniques, including: expression and purification of proteins, and various protein crystallization techniques
– Gained a basic knowledge for how to interpret electron density maps used in three-dimensional protein structure determination
– Presented my research project at an internal poster presentation
Education
University of Maryland College Park
Bachelor’s Degree, Cell Biology and Genetics
Activities and Societies: Organic Chemistry Tutor – Primannum Honor Society, Chemistry TA, Phi Beta Kappa, Clinical Volunteer – HSC Pediatric Center
Ledyard High School
High School, General Studies
Antibodies are used extensively for a
wide range of basic research and clinical applications. While an
abundant and diverse collection of antibodies to protein antigens have
been developed, good monoclonal antibodies to carbohydrates are much
less common. Moreover, it can be difficult to determine if a particular
antibody has the appropriate specificity, which antibody is best suited
for a given application, and where to obtain that antibody. Herein, we
provide an overview of the current state of the field, discuss
challenges for selecting and using antiglycan antibodies, and summarize
deficiencies in the existing repertoire of antiglycan antibodies. This
perspective was enabled by collecting information from publications,
databases, and commercial entities and assembling it into a single
database, referred to as the Database of Anti-Glycan Reagents (DAGR).
DAGR is a publicly available, comprehensive resource for
anticarbohydrate antibodies, their applications, availability, and
quality
Monoclonal antibodies have
transformed biomedical research and clinical care. In basic research,
these proteins are used widely for a myriad of applications, such as
monitoring/detecting expression of biomolecules in tissue samples,
activating or antagonizing various biological pathways, and purifying
antigens. To illustrate the magnitude and importance of the antibody
reagent market, one commercial supplier sells over 50 000 unique
monoclonal antibody clones. In a clinical setting, antibodies are used
frequently as therapeutic agents and for diagnostic applications. As a
result, monoclonal antibodies are a multibillion dollar industry, with
antibody therapeutics estimated at greater than $40 billion annually,
diagnostics at roughly $8 billion annually, and antibody reagents at $2
billion annually as of 2012
Perspectives on Anti-Glycan Antibodies Gleaned from Development of a Community Resource Database
Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States
ACS Chem. Biol., Article ASAP
DOI: 10.1021/acschembio.6b00244
Publication Date (Web): May 25, 2016
Copyright © 2016 American Chemical Society
*E-mail: gildersj@mail.nih.gov.
ACS Editors’ Choice – This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
MAXY
Rest in peace baby. I hope puppy heaven is filled with treats and marrow bones. I'll miss you Maxy.
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