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Friday, 9 December 2016

Dr Joelle Prunet



Dr Joelle Prunet

  • Senior Lecturer (Chemistry)
telephone: 01413308774
emailJoelle.Prunet@glasgow.ac.uk

A4-13 Organic Section, Chemistry, Joseph Black Building, Glasgow G12 8QQ

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links
https://uk.linkedin.com/in/joelle-prunet-36954315



Experience

Senior Lecturer - Head of Organic Chemistry

University of Glasgow

 – Present (7 years 5 months)

Directrice de Recherche

CNRS

 –  (5 years 11 months)

Education

Harvard University

PhD, Organic Chemistry

PhD advisor: Professor David A. Evans

Ecole Normale Superieure Paris

BsC

Lycee Saint-Genevieve

Research Interests

The main research interest of the Prunet group is the synthesis of biologically active natural products, such as taxol, a powerful antitumor agent, or dolabelide C and hexacyclinic acid, molecules with cytotoxic activity. In our approaches towards the target molecules, we uncover problems that cannot be easily solved by known reactions, and to overcome these difficulties we try to develop new methodologies that can also be applied to other syntheses.
‌‌Joelle Prunet - Taxol  Image result for university of glasgowPublication Highlights
  • Gamba-Canchez, D.; Prunet, J. J. Org. Chem. 2010, 75, 3129-3132 Synthesis of Modified Methyl Furanosides by Intramolecular Oxa-Michael Reaction followed by Pummerer Rearrangement.
  • Ma, C.; Schiltz, S.; Le Goff, Xavier F.; Prunet, J. Chem. Eur. J. 2008, 7314-7323 Ring-Closing Metathesis in the Synthesis of BC Ring-Systems of Taxol.
  • Toueg, J.; Prunet J. Org. Lett. 2008, 10, 45-48 Dramatic Solvent Effect on the Diastereoselectivity of Michael Addition: Study towards the Synthesis of the ABC Ring-System of Hexacyclinic Acid.
  • Rotulo-Sims, D.; Prunet J. Org. Lett. 2007, 9, 4147-4150 Tandem Conjugate Addition-Elimination for the Diastereoselective Synthesis of 4E-Alkenyl Syn 1,3-Diols.
  • Vincent, A.; Prunet, J. Synlett 2006, 2269-2271 Enantioselective Synthesis of the C1-C15 Fragment of Dolabelide C.


Ma, C., Letort, A., Aouzal, R., Wilkes, A., Maiti, G., Farrugia, L. J., Ricard, L., and Prunet, J. (2016) Cascade metathesis reactions for the synthesis of taxane and isotaxane derivatives. Chemistry: A European Journal, 22(20), pp. 6891-6899. (doi:10.1002/chem.201600592) (PMID:27062670)
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