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Saturday, 20 October 2018

Kalyan Kumar Pasunooti


Dr. Kalyan Kumar Pasunooti

Kalyan Kumar Pasunooti,



Dr. Kalyan Kumar Pasunooti pursued his PhD degree from Nanyang Technological University (NTU) (www.ntu.edu.sg), Singapore (2007 – 2011) in the field of Medicinal, Peptide & Protein chemistry. His graduate research work is focused on “Synthesis of bioactive amino acid building blocks and their applications towards the peptides and glycopeptides.” His have total 16 years of academic and industry experience with major multinationals companies & academic institutions and have worked with many collaborative professors around the globe. He authored with more than 28 international peer-reviewed high impact publications such as PNAS, Wily (Angew Chemie), RSC (Chem Comm and Org Biomol Chem), most of American Chemical Society journals (Journal of American Chemical Society, Org. Lett., ACS Chem Bio, J Comb Chem and Bioconugate Chem) and Elsevier (Tetrahedron Letters) journals which are featured many times in Chem. Eng. News and other journals. He holds American patent while work with Johns Hopkins-School of Medicine, USA and this molecule in phase II clinical trials for treating cancer.
Prior to his graduate studies, he spent 5 years as a research scientist in reputable research organizations namely GVK Bio, India (www.gvkbio.com) (2006-2007) and Dr. Reddy’s Laboratories Ltd (www.drreddys.com) (2003-2006) in India. After his PhD graduation, he worked for world leading research institutes such as Johns Hopkins-School of Medicine, USA (www.hopkinsmedicne.org) (2012-2013), Nanyang Technological University-NTU, Singapore) (www.ntu.edu.sg) (2013 – 2017) and Singapore MIT Alliance for research & Technology-SMART (www.smart.mit.edu) (2017–2018). His research interests focused on development of next generation biologically relevant peptide & protein therapeutics using their newly discovered methodologies for biomedical applications.
He has excellent skills in designing synthesis, purification and characterization of complex peptide and small molecules for medicinal chemistry applications. He gained extensive experience in Medicinal, Carbohydrate, Peptide & Protein and nucleotide & nucleoside Chemistry and familiar with modern methods and experienced in designing & executing synthesis for various bioactive peptide and small molecule inhibitors. He well versed in synthesis and characterization of complex organic molecules and with the analytical data interpretation.

Dr. Kalyan Kumar Pasunooti

Research Scientist at Singapore-MIT Alliance for Research & Technology Centre

Singapore'

Accomplished Peptide, Protein and Medicinal chemist with 16 years of academic and industrialexperience in the field of drug discovery and development. Specializations: Peptide & Protein Chemistry,Medicinal Chemistry (Drug Discovery and Development) and Chemical Biology.

ExperienceSingapore-MIT Alliance for Research & Technology Centre

Research Scientist

Company NameSingapore-MIT Alliance for Research & Technology Centre

  • Jul 2017 – Present

    1 yr 4 mos

    Singapore

    Medicinal Chemistry and Drug Discovery

  • Research Fellow

    Nanyang Technological University, Singapore

    Oct 2013 – Jun 2017

    3 yrs 9 mos

    Singapore

    Peptide & Protein Chemistry and Medicinal Chemistry

  • Postdoctoral Fellow

    Johns Hopkins Medicine

    May 2012 – Sep 2013

    1 yr 5 mos

    Baltimore, Maryland Area

    Medicinal chemistry, Drug Discovery, Pharmacology and Chemical Biology

  • Postdoctoral Associate

    Nanyang Technological University

    Jul 2011 – Mar 2012

    9 mos

    Singapore

    Organic synthesis, Peptide & Carbohydrate chemistry and Medicinal chemistry.

  • Senior Research Associate in Medicinal Chemistry

    GVK Biosciences

    Jan 2007 – Jul 2007

    7 mos

    Hyderabad Area, India

    Synthesis of bioactive molecules for medicinal chemistry applications.

  • Junior Scientist in Medicinal Chemistry (Anti-Infective group)

    Dr. Reddy's Laboratories

    Aug 2003 – Dec 2006

    3 yrs 5 mos

    Hyderabad Area, India

    Medicinal chemistry (Anti-Infective group): My work entails design and synthesis of newoxazolidinone derivatives and new chemical entities as novel antibacterial agents. As a researchscientist my job demanded me to carry out extensive literature survey to design possible syntheticroutes for a proposed molecule and to carry out the total synthetic part in the laborator... See more
    • Education

    • Nanyang Technological University

      PhD
      Organic and Bioorganic chemistry
       – 

    • Osmania University

      M. Sc
      Physical Organic Chemistry
       – 

    • Kakatiya University

      B. Sc,
      Mathematics Physics Chemistry
       – 
     
     
     Research Scientist at Singapore-MIT Alliance for Research and Technology

    Abstract Image
    Palladium-catalyzed acetoxylation of the primary γ-C(sp3)–H bonds in the amino acids Val, Thr, and Ile was achieved using a newly discovered 5-methylisoxazole-3-carboxamide directing group. The γ-acetoxylated α-amino acid derivatives could be easily converted to γ-mercapto amino acids, which are useful for native chemical ligation (NCL). The first application of NCL at isoleucine in the semisynthesis of a Xenopus histone H3 protein was also demonstrated.

    5-Methylisoxazole-3-carboxamide-Directed Palladium-Catalyzed γ-C(sp3)–H Acetoxylation and Application to the Synthesis of γ-Mercapto Amino Acids for Native Chemical Ligation

    School of Biological Sciences, Nanyang Technological University, Singapore 637551
    Org. Lett., 2016, 18 (11), pp 2696–2699
    DOI: 10.1021/acs.orglett.6b01160
    Publication Date (Web): May 24, 2016
    Copyright © 2016 American Chemical Society
    *E-mail: cfliu@ntu.edu.sg.
    link
    https://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b01160
    hps://pubs.acs.org/doi/suppl/10.1021/acs.orgletttt.6b01160/suppl_file/ol6b01160_si_001.pdf
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    1 comment:

    1. creative peptides27 March 2019 at 07:00

      Peptide chemists have a myriad of approaches available to optimize lead peptide structures for activity, potency and the desired selectivity for the target of interest. Thus multiple modifications and/or longer-range structural features (e.g. Peptide Modification

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