Giovanna Bruni

Giovanna Bruni PhD

 University of Pavia, Pavia

Department of Chemistry

 

University of Pavia

Department of Chemistry

Pavia, Italy

Via Taramelli 12, 27100 Pavia Phone : +39 0382 987325 Fax : +39 0382 528544

 

 

 

 

LINKS

https://www.researchgate.net/profile/Giovanna_Bruni

https://it.linkedin.com/pub/giovanna-bruni/8b/774/7a

E-mail address

giovanna.bruni@unipv.it

Phone

+39 0382 987667 (office) +39 0382 987 797 (lab)

The long experience in the field of the physico-chemical characterization of pharmaceutical solids and the expertise gained in the use of thermal techniques and electron microscopy are the basis for an activity of problem solving in the pharmaceutical industry, for example in relation to the phenomena of polymorphism, pseudo-polymorfism and amorphism, the drug-excipient compatibility and the investigation of strategies to improve the solubility and other properties of drugs.

RESEARCH EXPERIENCE

• May 1994-present, · University of Pavia Department of Chemistry - Section of Physical Chemistry
  Italy · Pavia

Teacher at the Faculty of Pharmacy and at the Master of Cosmetologic Sciences.
Scientific responsible of research agreements with pharmaceutical factories.
Author and co-author of about eighty scientific publications on peer-reviewed international jounals (ISI).
Referee for international scientific journals and Associate Editor of Journal of Thermal Analysis and Calorimetry.

EDUCATION

• November 1994 , University of Pavia
  PhD in Pharmaceutical Chemistry and Technology.
  Italy · Pavia
• Jul 1990, University of Pavia
  Degree in Pharmacy.
  Italy · Pavia
• November 1989, University of Pavia
  Degree in Pharmaceutical Chemistry and Technology.
  Italy · Pavia

Teachings	Physical Chemistry - Course A and B (Master of Science in Pharmacy)
Curriculum	Bruni_CV
Publications	G. Brown, C. Milanese, G. Bellazzi, V. Berbenni, P. Cofrancesco, A. Marini, M. Villa, "Quantification of drug amorphous fraction by DSC", J. Therm. Anal. Calorim., 2007.89, 761-766 G. Bruni, V. Berbenni, C. Milanese, A. Swivel, A. Cardini, E. Viganò, Lanfranconi S., A. Marini, "Thermodynamic relationships between nateglinide polymorphs," J. Pharm. Biomed. Anal., 2009, 50, 764-770 G. Bruni, V. Berbenni, C. Milanese, A. Swivel, A. Cardini, Lanfranconi S., A. Marini, "New modifications of solid nateglinide", J. Pharm. Biomed. Anal., 2010, 51, 1054-1059 G. Bruni, V. Berbenni, C. Milanese, A. Swivel, A. Marini, "Drug-excipient compatibility studies in binary and ternary mixtures by physico-chemical techniques", J. Therm. Anal. Calorim., DOI: 10.007 / s10973-009-0382-z, Online First G. Bruni, F. Gozzo, D. Capsoni, M. Bini, P. Macchi, P. Simoncic, V. Berbenni, C. Milanese, A. Swivel, S. Ferrari, A. Marini, "Thermal, spectroscopic and ab -initio structural characterization of polymorphs carprofen, "Journal of Pharmaceutical Sciences, 2011, 100, 2321-2332
Collaborations	Fabia Gozzo, Paul Scherrer Institut, Swiss Light Source, 5232 Villigen PSI, Switzerland (fabia.gozzo@psi.ch) Csaba Novak, Institute of General and Analytical Chemistry, Budapest University of Technology and Economics, Budapest, Hungary (Cs-novak@mail.bme.hu) Andrea Cardini, AMSA (Anonima Synthetic Materials Association), Italy Como (a.cardini@amsacomo.it)

University of Pavia

Pavia, Italy

INFORMATION, Address,Strada Nuova, 65, 27100, Pavia, Italy

• Website, http://www.unipv.it/
• Phone,+39 0382 987878
• Fax,+39 0382 987874

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Lakshmi C. Kasi Viswanath

Assistant Professor of Chemistry at Oklahoma Baptist University

500 W. University, Shawnee, OK 74804

• 
  Oklahoma State University - Stillwater

  Department of Chemistry

  Stillwater, OK, United States

LINKS

• https://www.linkedin.com/pub/lakshmi-c-kasi-viswanath/37/249/23

  
  

  
  

https://www.researchgate.net/profile/Lakshmi_Viswanath2

https://www.okbu.edu/directory/lakshmi-viswanath

• lakshmi.viswanath@okbu.edu

Experience

Assistant Professor of Chemistry

Oklahoma Baptist University

August 2013 – Present (2 years 2 months)Shawnee

Doctoral Candidate

Oklahoma State University

January 2009 – Present (6 years 9 months)Stillwater, OK- 74075

GRADUATE RESEARCH ASSISTANT

Dept. of Chemistry, Oklahoma State University, Stillwater, OK
• Conducted research in Organic Chemistry related to the development of new electron donor/acceptor Subphthalocyanine derivatives involving porphyrins, perylenes and hydroquinones
• Demonstrated ability and extensive hands-on experience in designing and executing multi-step synthesis, optimizing chemical processes and scale-up of synthetic methods
• Outstanding expertise in analyzing and identifying organic compounds by modern analytical techniques [NMR (1H, 13C, 19F, 11B), FT-IR, UV-Vis, Fluorescence Spectroscopy, HRMS, MALDI-TOF, GC/MS, LC/MS, TGA, DSC, HOPM, Cyclic Voltammetry etc.]
• Highly skilled in organic chemicals separation and purification by traditional and modern methods (Flash Chromatography, MPLC etc.)
• Adept in SciFinder Scholar, ChemDraw

GRADUATE TEACHING ASSISTANT

Dept. of Chemistry, Oklahoma State University, Stillwater, OK
• Instructed students on General chemistry and Organic Chemistry
• Conducted office hours every week and assisted students in their homework and course projects


PUBLICATIONS AND PRESENTATIONS

• Synthesis of Symmetrical and Unsymmetrical Subphthalocyanine Dimers Containing a Hydroquinone Bridge, (Manuscript in preparation)
• Synthesis of Electron Donor-Acceptor Subphthalocyanine Derivatives of Porphyrins (Manuscript in preparation)
• Axial Reactivity of Dodecafluorosubphthalocyanine on ortho and para substituted perylene diimides (Manuscript in preparation)
• Paper Presentation on “Synthesis of Strained Porphyrinophanes as Novel Systems for Reactivity” in the 45th Midwest Regional Meeting American chemical Society, Wichita, KS, Oct-2010
• Poster Presentation on “Synthesis and Characterization of Subphthalocyanine–Porphyrin and Subphthalocyanine–Perylene Donor/Acceptor Conjugates ” in the 245th ACS National Meeting and Exposition, New Orleans, LA, Apr-2013

Senior Research Officer

Sanmar Speciality Chemicals, Chennai

June 2006 – January 2009 (2 years 8 months)

• Designed and executed the syntheses of the target molecules and optimized existing chemical processes
• Handled 15 different projects ranging from 50 mg to 3 Kg dispatches
• Ample experience in handling pyrophoric and moisture sensitive chemicals such as n-BuLi, and Raney Nickel

Education

Anna University

Master of Science (M.Sc.), Applied Chemistry, A

2004 – 2006

Project: Synthesis and Characterization of Symmetrical Chiral Liquid Crystal Dimers
o Synthesized five different organic based symmetrical chiral liquid crystal dimers and characterized their Liquid crystal Phases using HOPM and DSC

Gold Medalist (Rank 1)

Madras University

Bachelor's degree, Chemistry, A

2001 – 2004

Recipient of Gold Medal (Rank 1)

Lakshmi C KASI VISWANATH

posted Oct 21, 2009, 8:58 AM by Faith Arrow   [ updated Mar 11, 2010, 2:52 PM ]

Lakshmi is a graduate student at Oklahoma State University and is very passionate to reach the lost with the word of Christ.  She actively participates at Hosanna Church, Stillwater, Oklahoma. She comes from India where she was used by God in ministering and working with youth groups. She has put a lot of hardwork for the New Testament Prophetic 101 class by attending the class and submitting all the homeworks.  We from FAMI are excited to come in contact with people like Lakshmi who burn for Christ....https://sites.google.com/site/famiwebclass/student-of-the-month/johndoe Dr. Lakshmi Viswanath Assistant Professor of Chemistry Wood Science, 206C OBU Box 61772 405-585-4133 lakshmi.viswanath@okbu.edu Biography Dr. Lakshmi Chockalingam Kasi Viswanath earned a bachelor’s degree in chemistry from Madras University in Chennai, India. She also earned a master’s degree in applied chemistry from Anna University in Chennai, India, a second master’s degree in philosophy in chemistry from Madurai Kamaraj University in Madurai, India, and a doctorate in organic chemistry from Oklahoma State University. Viswanath previously served as the senior research officer for Sanmar Specialty Chemicals in Chennai, India. She has been awarded a gold medal- top rank- in the master’s program at Anna University, and the gold medal- top rank- bachelor’s program at Madras University.

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Dr. Paolo Lombardi

Owner, Naxospharma; Co-owner & CSO, AESIS Therapeutics

links

https://it.linkedin.com/pub/paolo-lombardi/6/3aa/ba1

• email.........p.lombardi@naxospharma.eu
• https://scholar.google.com/citations?user=LK22z00AAAAJ&hl=en

• Phone	+39-0238203181 (Work)
  Address	Naxospharma srl via G. Di Vittorio, 70 20026 Novate Milanese Italy

Summary

Professional with extensive experience in the Pharmaceutical Industry. Presently, scientist-entrepreneur.
• Backgrounds in organic synthetic chemistry, process research chemistry, medicinal chemistry.
• Demonstrated expertise in the drug discovery in important therapeutic fields by successful leadership of many result-oriented research projects.
• Creativity and strong commitment to the invention and IP protection of several therapeutical New Chemical Entities, some of which have been advanced into clinical development and into global market.
• Capacity in planning the preclinical iter of candidate compounds, from the design of viable syntheses for the scale-up process up to their earlier therapeutic evaluations. Insight into IND development processes.
• Basically a self-starter, self-motivated drug hunter with a ‘can-do’ spirit and a sense for focusing on creating the drug, very comfortable in operating in start-up situations, securing skills in managing and motivating research staff and facilitating relationships with the scientific community, with the vision and creativity to ‘make things happen’.
• Co-inventor and Inventor of 65+ patents, author and co-author of 150+ research papers, reviews, abstracts, invited lectures and seminars. Teaching appointments at Universities, Master courses & Specialist Schools

https://scholar.google.it/citations?user=LK22z00AAAAJ&hl=en

Specialties: My( his ) statements:

• Knowing about innovation is one thing; making it work is another.
• Chemistry-driven drug discovery may be politically incorrect, but it works.
• Life sciences which neglect chemistry should arouse our suspicion.
• Cells follow the laws of chemistry
• We wish to cooperate with those who have both knowledge and integrity
• Nature does not care what politicians call it, she just keeps on doing it


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Experience

Co-founder & CSO

AESIS Therapeutics

 

December 2013 – Present (1 year 9 months)Jesi, Ancona, Italy

A dual spin out company from Naxospharma (Milan, Italy) and Aromics (Barcelona, Spain) aiming at moving inventive findings from the two parent companies into early stage clinical development. Current projects: new agents against HER2+ breast cancer and against malignant mesotheliomas.

President and Owner

Naxospharma srl

April 2003 – Present (12 years 5 months)Milan Area, Italy

Chemistry-driven, R&D-only small pharma/biotech aiming at finding new drug candidates to license-out for further development.
Incorporates the culture, know how elements and the people most strongly related to the major achievements of late Farmitalia: distamycin (Herperal ®); daunomycin (Daunoblastin®): doxorubicin (Adriblastin®, Adriamycin®); epirubicin (Farmorubicin®, Ellence®); idarubicin (Zavedos®); exemestane (Aromasin®).
Grants from European Commission, Italian Ministries, Regional and local authorities. Recipient of Premio Mercurio d'Oro (Golden Mercury Award) 2010, Regione Lombardia.
Recipient of Premio Internazionale (International Prize) Le Fonti as the best Research & Biotech Company http://www.premiolefonti.it/vincitori.php
Creation of 5 patents portfolio.
Board:
Paolo Lombardi, PhD - President, owner
Prof. Federico-Maria Arcamone - Member
Caterina Vallani, DVM – Member, co-owner

Corporate coworkers and scientists on Linkedin:
Franco Buzzetti
Gaetano Fiorillo
Tanjia Monir Syeda
Cristina Geroni
Carlo Battistini
Laura Franchini

Head of Medicinal Chemistry

Chrysalon

June 2001 – January 2003 (1 year 8 months)

Lyon area
Partecipating in creating value for this biotech since its foundation.

Consultant

IBI G. Lorenzini

June 1997 – December 1998 (1 year 7 months)

Rome area
Advise and counsel in the definition of new targets and new “state of the art” technologies for suitable research programmes. Building network of external collaborators. Starting-up projects.

Vice-President for Chemistry

Menarini Ricerche S.p.A.

July 1989 – September 1996 (7 years 3 months)

Rome area
Building and development of a chemistry-driven competitive Drug Discovery Department. Discovery chemistry (design and synthesis of DNA-interacting compounds, receptor antagonists, enzyme inhibitors), Structural chemistry (high resolution NMR and MS, molecular modelling), Technology chemistry (solid phase continuous flow synthesis, peptides, libraries). Direction of projects and programmes to discover anticancer and antiviral agents, neurokinin antagonists, antiprotozoarian agents, aromatase inhibitors. Establishing efficiency and success rate of delivering drug candidates. Discovered NCEs which entered pre- and clinical development (Sabarubicin, 3rd generation antitumour anthracycline).
Creation of 18 patents corporate portfolio.

Project leader

Farmitalia Carlo Erba

September 1975 – June 1989 (13 years 10 months)

Milan area
Antinfective research: contributions to the chemistry and synthesis of non-classical β-lactams: penems, nocardicin and clavulanic acid analogues
Process research chemistry: studies of viable syntheses of β-lactams, anthracyclines and their intermediates
Anticancer research: to discover inhibitors of aromatase (ultimate enzyme in oestrogens biosynthesis) as potential drugs for the treatment of breast and other hormone-dependent tumours. Achieved the goal of discovering Exemestane (marketed as AROMASIN) and the clinical follow-up Minamestane, both orally active for post-menopausal breast cancer therapy. Provided viable industrial synthetic methods for both compounds,
Creation of 34 patents corporate portfolio.

Research assistant

Southampton University Chemistry Department

February 1972 – October 1972 (9 months)

Research work on catalysed Diels-Alder cycloaddition for the syntheses of industrially useful compounds in the laboratory of late Prof. R. C. Cookson (Research grant presented by Firmenich et Cie., Geneve, CH).

2nd Lieutenant Naval Weapons

Italian Navy

April 1970 – December 1971 (1 year 9 months)

Reserve officer of the civil service. Ammunition factory at Aulla. Warship “C. Duilio”.

Education

University of Southampton

PhD, Chemistry

1972 – 1975

Dissertation in synthetic organic chemistry. Supervisor: Prof. R. C. Cookson

Italian Naval Academy at Livorno

Midshipman, Naval Weapons

1970 – 1970

Drilling period (4 months) en route to become a Navy officer of the civil service

Università degli Studi di Milano

doctor, Chemistry

1964 – 1969

Dissertation in the chemistry of natural products

liceo vittorio veneto

Diploma, science

1960 – 1964

Publications

6-Methylenandrosta-1, 4-diene-3, 17-dione (FCE 24304): a new irreversible aromatase inhibitor D Giudici, G Ornati, G Briatico, F Buzzetti, P Lombardi, E Di Salle Journal of steroid biochemistry 30 (1), 391-394	131	1988
New developments in antitumor anthracyclines F Arcamone, F Animati, G Capranico, P Lombardi, G Pratesi, S Manzini, ... Pharmacology & therapeutics 76 (1), 117-124	95	1997
Synthesis of aryl 2-benzofuranyl and aryl 2-indolyl carbinols of high enantiomeric purity via palladium-catalyzed heteroannulation of chiral arylpropargylic alcohols M Botta, V Summa, F Corelli, G Di Pietro, P Lombardi Tetrahedron: Asymmetry 7 (5), 1263-1266	93	1996
Doxorubicin disaccharide analogue: apoptosis-related improvement of efficacy in vivo F Arcamone, F Animati, M Berettoni, M Bigioni, G Capranico, AM Casazza, ... Journal of the National Cancer Institute 89 (16), 1217-1223	71	1997
Berberine: new perspectives for old remedies M Tillhon, LMG Ortiz, P Lombardi, AI Scovassi Biochemical pharmacology 84 (10), 1260-1267	68	2012
A rapid, safe and convenient procedure for the preparation and use of diazomethane P Lombardi Chemistry and industry	54	1990
4-Aminoandrostenedione derivatives: a novel class of irreversible aromatase inhibitors. Comparison with FCE 24304 and 4-hydroxyandrostenedione E Di Salle, D Giudici, G Ornati, G Briatico, R D'alessio, V Villa, P Lombardi The Journal of steroid biochemistry and molecular biology 37 (3), 369-374	43	1990
Large scale preparation of enantiopure S-ketoprofen by biocatalysed kinetic resolution N D’Antona, P Lombardi, G Nicolosi, G Salvo Process Biochemistry 38 (3), 373-377	39	2002
Substituted 1-[(benzofuran-2-yl)-phenylmethyl]-imidazoles as potent inhibitors of aromatase in vitro and in female rats in vivo R Whomsley, E Fernandez, PJ Nicholls, HJ Smith, P Lombardi, ... The Journal of steroid biochemistry and molecular biology 44 (4), 675-676	39	1993
Exemestane, a new steroidal aromatase inhibitor of clinical relevance P Lombardi Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1587 (2), 326-337	37	2002
A new irreversible aromatase inhibitor, 6-methylenandrosta-1, 4-diene-3, 17-dione (FCE 24304): antitumor activity and endocrine effects in rats with DMBA-induced mammary tumors T Zaccheo, D Giudici, P Lombardi, E Di Salle Cancer chemotherapy and pharmacology 23 (1), 47-50	37	1989
New anthracycline disaccharides. Synthesis of L-daunosaminyl-α (1→ 4)-2-deoxy-L-rhamnosyl and of L-daunosaminyl-α (1→ 4)-2-deoxy-L-fucosyl daunorubicin analogues F Animati, F Arcamone, M Berettoni, A Cipollone, M Franciotti, P Lombardi J. Chem. Soc., Perkin Trans. 1, 1327-1329	29	1996
6-substituted androsta-1, 4-diene-3, 17-diones F Buzzetti, N Barbugian, P Lombardi, EDI Salle US Patent 4,808,616	25	1989
Biophysical studies on the effect of the 13 position substitution of the anticancer alkaloid berberine on its DNA binding D Bhowmik, M Hossain, F Buzzetti, R D’Auria, P Lombardi, GS Kumar The Journal of Physical Chemistry B 116 (7), 2314-2324	22	2012
4-amino androstendione derivatives and process for their preparation F Faustini, R d'Alessio, V Villa, EDI Salle, P Lombardi US Patent 4,757,061	22	1988
Binding of Epstein-Barr virus nuclear antigen 1 to DNA: inhibition by distamycin and two novel distamycin analogues G Feriotto, A Ciucci, C Mischiati, F Animati, P Lombardi, P Giacomini, ... European Journal of Pharmacology: Molecular Pharmacology 267 (2), 143-149	21	1994
Synthesis of Two Distamycin Analogs and Their Binding Mode to d (CGCAAATTTGCG) 2 in the 2: 1 Solution Complexes as Determined by Two-Dimensional 1H-NMR F Animati, FM Arcamone, MR Conte, P Felicetti, A Galeone, P Lombardi, ... Journal of medicinal chemistry 38 (7), 1140-1149	20	1995
Killing of tumor cells: a drama in two acts V Giansanti, M Tillhon, G Mazzini, E Prosperi, P Lombardi, AI Scovassi Biochemical pharmacology 82 (10), 1304-1310	17	2011
Antimalarial activity of synthetic analogues of distamycin P Lombardi, A Crisanti Pharmacology & therapeutics 76 (1), 125-133	16	1997
Biochemical and pharmacological activity of novel 8-fluoroanthracyclines: influence of stereochemistry and conformation. F Animati, F Arcamone, M Bigioni, G Capranico, C Caserini, M De Cesare, ... Molecular pharmacology 50 (3), 603-609	16	1996

see
https://scholar.google.com/citations?user=LK22z00AAAAJ&hl=en&cstart=20&pagesize=20

1. 1. 
2. Directions

   Naxospharma SRL  
   
3. Chemistry Lab
6. Address:  Via Giuseppe di Vittorio, Novate Milanese, Italy

   Phone: +39 02 3820 2846

AESIS


 



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