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Sunday, 28 December 2014

One Day One Scientist honoured..........Prof Steven V Ley 28 Dec 2014


Professor Steven Ley is currently Director of Research at the Department of Chemistry, University of Cambridge following on from 21 years as the BP (1702) Professor of Chemistry and is also a Fellow of Trinity College.  Steve obtained his PhD from Loughborough University with Professor Harry Heaney and afterwards carried out postdoctoral research with Professor Leo Paquette (Ohio State University) then Professor Derek Barton (Imperial College).  He was appointed as a lecturer at Imperial College in 1975, promoted to Professor in 1983, and then to Head of Department in 1989.  In 1990 he was elected to the Royal Society (London) and was President of The Royal Society of Chemistry from 2000-2002.

Steve’s research interests are varied and span many disciplines including new synthetic methodologies, the total synthesis of natural products and the development of enabling technologies for chemical synthesis especially in the area of flow chemistry technologies.  He has published over 780 papers and has gained 50 major awards including recently the Tetrahedron Prize for Creativity in Organic Chemistry (Elsevier); Heinrich Wieland Prize (Boehringer Ingelheim, Germany); The Paracelsus Prize (Swiss Chemical Society); The Royal Medal (The Royal Society, London),  The Longstaff Prize (The Royal Society of Chemistry) and the IUPAC Thales-Nano Prize in Flow Chemistry.

Prof Steven V Ley FRS CBE FMedSci

Department of Chemistry
University of Cambridge
Lensfield Road, Cambridge
England, CB2 1EW
United Kingdom
Email: svl1000@cam.ac.uk
Tel: +44 (0)1223 336398


Our research focusses on organic chemistry, the science that explores all aspects of organic compounds such as molecular structure, composition, the synthesis and properties of carbon-containing compounds and the methods and strategies that we use to achieve this.
We are committed to promoting excellence in postgraduate research through rigorous skills training and the provision of excellent laboratory facilities. We engender ambition and adventure to help our group members go on to become future pioneers and leaders in their own right.
The heart of our research interests lies in the discovery and development of new chemical methodologies, in the broadest sense. A main focus for us is tackling the challenges facing chemical manufacturing in the future and addressing strategic needs for more sustainable processes in chemical synthesis.

Steven Victor Ley FRS is the BP Professor of Organic Chemistry at the University of Cambridge, and is a Fellow of Trinity College. He was President of the Royal Society of Chemistry (2000–2002) and was made a CBE in January 2002. In 2011, he was included by The Times in the list of the “100 most important people in British science”.[1]
His main research field is the total synthesis of biomolecules. His group has published extensively on this topic, and has completed the synthesis of more than 140 natural target compounds, with notable examples including indanamycin, routiennocin, avermectin B1a, okadaic acid, spongistatin, thapsigarginepothilone A, antascomicin B, bengazole A andrapamycin. His total synthesis of azadirachtin, completed in 2007, is widely regarded as one of the major landmarks in total synthesis. In the course of this work, he has also made substantial advances in many areas of organic chemistry, including the development of new catalystsprotecting groups and reagents. He is one of the inventors of TPAP, a widely employed oxidizing reagent. He has also pioneered the use of immobilized reagents and flow techniques in multi-step organic synthesis. This work now incorporates flow chemistry for multistep organic synthesis applications.

Honours and Awards[edit]

Steve Ley's work of almost 800 papers has been recognised by about 40 major prizes and awards, the most recent of which are:

798. The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions, S. Glockner, D.N. Tran, R.J. Ingham, S. Fenner, Z.E. Wilson, C. Battilocchio, S.V. Ley Org. Biomol. Chem.2015, 13, 207
797. Process intensification for the continuous flow hydrogenation of ethyl nicotinate, T. Ouchi, C. Battilocchio, J.M. Hawkins, S.V. LeyOrg. Process Res. Dev.2014, 18, 1560-1566
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796.  Reconfiguration of a continuous flow platform for extended operation: application to a cryogenic fluorine-directed ortho-lithiation reaction, J.A. Newby, D.W. Blaylock, P.M. Witt, R.M. Turner, P.L. Heider, B.H. Harji, D.L. Browne, S.V. Ley, Org. Process Res. Dev.2014, 18, 1221-1228
795. Design and application of a low-temperature continuous flow chemistry platform, J.A. Newby, D.W. Blaylock, P.M. Witt, J.C. Pastre, M.K. Zacharova, S.V. Ley, D. L. Browne, Org. Process Res. Dev.,2014, 18, 1211-1220
tfigure6793. Regioselective preparation of saturated spirocyclic ring-expanded fused pyrazoles R.R. Merchant, D.M.Allwood, D.C.Blakemore, S.V.Ley, J. Org. Chem.2014, 880-8811
792. Flow chemistry meets advanced functional materials R.M. Myers, D.E. Fitzpatrick, R.M. Turner, S.V. Ley, Chem. Eur. J.  2014, 20, 12348-12366
792. Chem. Eur. J., 2014, 20, 12348-12366
791. Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology M.A. Kabeshov, B. Musio, P.R.D. Murray, D.L. Browne, S.V.Ley, Org. Lett.  2014, 16, 4618-4621
790. Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium G. Rouquet, D.C. Blakemore, S.V. Ley, Chem. Comm. 2014, 50, 8908-8911
789. Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations, M. Baumann, I.R. Baxendale, C.H. Hornung, S.V. Ley, M.V. Rojo, K.A. Roper, Molecules 2014, 19, 9736-9759

External links


  1.  [1]
  2.  [2]
  3.  Tetrahedron Prize for Creativity in Organic Chemistry
  4. Jump up^ "Director of the Department of Chemistry, University of Cambridge, UK - Heinrich Wieland Prize 2009 for outstanding achievements in the synthesis of key natural products".http://www.heinrich-wieland-prize.de. Retrieved 7 October 2014.



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