DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair,With death on the horizon, This will not stop me, Gods call only..........
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contributio
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Thursday, 25 December 2014

One day One Scientist Honoured........Dr C. Oliver Kappe 26 DEC 2014


cokappe
THE KAPPE LABORATORY
Institute of Chemistry, University of Graz, Austria
CHRISTIAN DOPPLER LABORATORY FOR MICROWAVE CHEMISTRY (CDLMC)Austria

C. Oliver Kappe is Professor of Chemistry at the University of Graz, Austria.


 
 The Kappe Laboratories are housed at the Institute of Chemistry (IfC), University of Graz,



He received his diploma- (1989) and his doctoral (1992) degrees in organic chemistry from the University of Graz where he worked with Professor Gert Kollenz on cycloaddition and rearrangement reactions of acylketenes.

 C. Oliver Kappe is Professor of Organic Chemistry and Director of the Christian Doppler Laboratory for Microwave Chemistry (CDLMC) at the University of Graz, Austria. He received his diploma- (1989) and his doctoral (1992) degrees in organic chemistry from the University of Graz where he worked with Professor Gert Kollenz on cycloaddition and rearrangement reactions of acylketenes. After periods of postdoctoral research work on reactive intermediates and matrix isolation spectroscopy with Professor Curt Wentrup at the University of Queensland in Brisbane, Australia (1993-1994) and on synthetic methodology/alkaloid synthesis with Professor Albert Padwa at Emory University in Atlanta, USA (1994-1996), he moved back to the University of Graz in 1996 to start his independent academic career. He obtained his "Habilitation" in 1998 in organic chemistry and was appointed Associate Professor in 1999. Since 2011 he holds the position of Professor of "Technology of Organic Synthesis" (Organische Synthesetechnologie) at the University of Graz. He has spent time as visiting scientist/professor at e.g. the Scripps Research Institute (La Jolla, USA, Professor K. Barry Sharpless, 2003), the Toyko Institute of Technology (Toyko, Japan, Professor T. Takahashi, 2008), the University of Sassari (Sassari, Italy, 2008), and the Sanford-Burnham Institute for Medical Research (Orlando, USA, 2010).

The co-author of ca. 300 publications, his main research interests have in the past focused on multicomponent reactions, combinatorial chemistry and the synthesis of biologically active heterocycles. More recently his research group has been involved with enabling technologies for synthetic chemistry, including microwave and continuous flow chemistry. For his innovative work in microwave chemistry he received the 2004 Prous Science Award from the European Federation for Medicinal Chemistry and the 2010 Houska Prize (100.000 €) in addition to a number of other awards.


DR SANJAY BAJAJ,,,,,,,,,,,,,,,,,,,DR ANTHONY CRASTO............PROF OLIVER KAPPE
FLOW CHEM CONFERENCE , MUMBAI, 22 JAN 2015......SELECTBIO

After periods of postdoctoral research work on reactive intermediates and matrix isolation spectroscopy with Professor Curt Wentrup at the University of Queensland in Brisbane, Australia (1993-1994) and on synthetic methodology/alkaloid synthesis with Professor Albert Padwa at Emory University in Atlanta, USA (1994-1996), he moved back to the University of Graz in 1996 to start his independent academic career. He obtained his "Habilitation" in 1998 in organic chemistry and was appointed Associate Professor in 1999. Since 2011 he holds the position of Professor of "Technology of Organic Synthesis" (Organische Synthesetechnologie) at the Instittue of Chemistry at the University of Graz. He has spent time as visiting scientist/professor at e.g. the Scripps Research Institute (La Jolla, USA, Professor K. Barry Sharpless, 2003), the Toyko Institute of Technology (Toyko, Japan, Professor T. Takahashi, 2008), the University of Sassari (Sassari, Italy, 2008), the Sanford-Burnham Institute for Medical Research (Orlando, USA, 2010) and the Federal University of Rio de Janeiro (Ri de Janeiro, Brazil, 2013).
The co-author of ca. 350 publications, his main research interests have in the past focused on multicomponent reactions, combinatorial chemistry and the synthesis of biologically active heterocycles. More recently his research group has been involved with enabling and process intensification technologies, including microwave and continuous flow chemistry. For his innovative work in microwave chemistry he received the 2004 Prous Science Award from the European Federation for Medicinal Chemistry and the 2010 Houska Prize (100.000 €) in addition to a number of other awards.
 
C. Oliver Kappe is currently Editor-in-Chief of the Journal of Flow Chemistry (Akadémiai Kiadó) and a board member of the Flow Chemistry Society. In addition he has been an Editor of the Journal QSAR and Combinatorial Sciences (Wiley-VCH, 2003-2007) and has served/serves on the Editorial/Advisory Boards of the Journal of Combinatorial Chemistry (ACS), Molecular Diversity (Springer), ChemMedChem and ChemSusChem (Wiley-VCH), Journal of Heterocyclic Chemistry (Wiley-VCH) and a number of other journals.
 

Publications

Prof. C. O. Kappe has co-authored ca. 350 scientific publications since 1988 in a variety of different fields, including review articles, books and book chapters. For an overview of publications and citations, see: Publications/Citations from ResearchID.com. His current H-index is 58 (September 2014).
He is most well-known for his work in the field of microwave chemistry and his laboratory has authored over 150 original research articles, reviews and books on microwave-assisted synthesis since 1999. He has contributed chapters to most of the available reference books on the subject and has published numerous other review and feature articles on microwave synthesis. 

Most notably among those is a 2004 review in Angewandte Chemie, which has been voted best review article in this journal and is currently (year 2013) the most cited review in microwave synthesis. The comprehensive books "Microwaves in Organic and Medicinal Chemistry" and "Practical Microwave Synthesis for Organic Chemists - Strategies, Instruments, and Protocols" were published with Wiley-VCH in 2005 (2nd ed. 2012) and 2009, respectively and are currently considered the standard reference books in the field.
Recent publications focus on continuous flow chemistry, the use of microreactors in organic chemistry and process intensification.
Recent Hot Papers from the Kappe Lab:


Microwave Effects in Organic Synthesis – Myth or Reality?
C. O. Kappe, B. Pieber, D. Dallinger,
Angew. Chem. Int. Ed. 2013, 52, 1088

In Situ Generation of Diimide from Hydrazine and Oxygen - Transfer Hydrogenation of Olefins in Continuous Flow.
B. Pieber, S. T. Martinez, D. Cantillo, C. O. Kappe

Continuous Flow Generation and Reactions of Anhydrous Diazomethane Using a Teflon AF-2400 Tube-in-Tube Reactor
F. Mastronardi, B. Gutmann, C. O. Kappe,
Org. Lett. 2013, 15, 5590

Shifting Chemical Equilibria in Flow – Efficient Decarbonylation Chemistry Driven by Annular Flow Regimes.
B. Gutmann, P. Elsner, T. Glasnov, D. M. Roberge, C. O. Kappe

Use of Continuous Flow Technology to Harness Hazardous Chemistries and Process Conditions – A Tool for the Manufacturing of Active Pharmaceutical Ingredients (Review)
B. Gutmann, D. Cantillo, C. O. Kappe
Angew. Chem. Int. Ed. 2015, 54, in press.




The Kappe Lab in the Press:

New Stirring Design for Microwaves


Microwave Quarrel Heats Up

Diazomethane without Tears. Or Explosions

An Interview with C. O. Kappe

Microwave Effects Debate

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new article
C. Oliver Kappe, University of Graz, Austria, and colleagues prepared for the first time the potential new platform molecule H2MF in pure form and converted it to the polyester precursor 5-hydroxy-4-keto-pentenoic acid (HKPA).
read at






Research

Research in the Kappe group focuses on enabling technologies in organic synthesis and related areas. Of primary current interest is the use of microwave dielectric heating and continuous flow/microreactor technology. We are particularly interested to improve existing and/or develop new synthetic procedures (in many cases of significant industrial interest) using both of these technologies, either separately, or in combination with each other. Emphasis is also placed on the sustainability of the developed procedures.
FLOW CHEMISTRY
The use of microreactors and contnuous flow equipment in general has opened up new horizons for synthetic organic chemistry and the chemical manufacturing industry. Microreaction technology is generally defined as the continuous flow processing of reactions within structured channels of 10-500 micrometer diameter. Because of the high surface-to-volume ratio in microchannels of this type, heat transfer is very efficient and reaction temperatures in microreactors can be changed efficiently by application or removal of heat. In addition, enhanced mass transfer characteristics, safer synthesis of dangerous compounds, isolation of air and moisture sensitive chemistry, and reduction of hazardous waste can all be realized using microreactors. The ability to efficiently optimize reaction conditions by control of residence time and rapid experimentation also add value to the technology by shortening production development lifecycles. A particularly attractive feature of microreaction technology is the ease with which reaction conditions can be scaled - without the need for reoptimization - through the operation of multiple systems in parallel (numbering-up, scaling-out), thereby achieving production scale capabilities.
Emphasis in our work in the area of flow chemistry is placed on process intensification techniques, in particular working in high-temperature/high-pressure environments (Novel Process Windows), often dealing with extremely hazardous chemical transformations. We also have an interest in working with multiphasic (gas/liquid, gas/liquid/solid) flow regimes.
Recent published examples of our flow chemistry projects are highlighted below:
Continuous Flow Microreactor Chemistry Under High Temperature/Pressure Conditions.
T. Razzaq, T. N. Glasnov, C. O. Kappe, Eur. J. Org. Chem. 2009, 1321-1325.
Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes.
M. Damm, T. N. Glasnov, C. O. Kappe, Org. Process Res. Develop. 2010, 14, 215-224.
 
The Microwave-to-Flow Paradigm: Translating High-Temperature Batch Microwave Chemistry to Scalable Continuous Flow Processes.
T. N. Glasnov, C. O. Kappe, Chem. Eur. J. 2011, 17, 11956-11968.
mw to flow
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Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles and Hydrazoic Acid Using a Safe and Scalable High-Temperature Microreactor Approach.
B. Gutmann, J.-P. Roduit, D. Roberge, C. O. Kappe, Angew. Chem. Int. Ed. 2010, 49, 7101-7105.
Mechanistic Insights on Azide-Nitrile Cycloadditions: On the Dialkyltin Oxide-Trimethylsilyl Azide Route and a New Vilsmeier-Haack-Type Organocatalyst.
D. Cantillo, B. Gutmann, C. O. Kappe, J. Am. Chem. Soc. 2011, 133, 4465-4475.

Safe Generation and Synthetic Utilization of Hydrazoic Acid in a Continuous Flow Reactor.
B. Gutmann, J.-P. Roduit, D. Roberge, C. O. Kappe, J. Flow Chem. 2012, 2,8-19.

tetrazole synthesis
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In Situ Generated Iron Oxide Nanocrystals as Efficient and Selective Catalysts for the Reduction of Nitroarenes in Continuous Flow.
D. Cantillo, M. Baghbanzadeh, C. O. Kappe, Angew. Chem. Int. Ed. 2012, 51, 10190-10193.

Hydrazine-Mediated Reduction of Nitro and Azide Functionalities Catalyzed by Highly Active and Reusable Magnetic Iron Oxide Nanocrystals.
D. Cantillo, M. Mirhosseini Moghaddam, C. O. Kappe, J. Org. Chem. 2013, 78, 4530-4542.

Immobilized Iron Oxide Nanoparticles as Stable and Reusable Catalysts for Hydrazine-mediated Nitro Reductions in Continuous Flow
M. Mirhosseini Moghaddam, B. Pieber, T. Glasnov, C. O. Kappe,
ChemSusChem 2014, 7, in press.
 

nitro
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Methylation Using Dimethylcarbonate Catalysed by Ionic Liquids Under Continuous Flow Conditions.
T. N. Glasnov, J. D. Holbrey, C. O. Kappe, K. R. Seddon, T. Yan, Green Chem. 2012, 14, 3071-3076.

DMC
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Direct Aerobic Oxidation of 2-Benzylpyridines in a Gas-Liquid Continuous-Flow Regime Using Propylene Carbonate as Solvent.
B. Pieber, C. O. Kappe, Green Chem. 2013, 15, 320-324.

oxidation

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Continuous Flow Synthesis of Adipic Acid from Cyclohexene Using Hydrogen Peroxide in High-Temperature Explosive Regimes.
M. Damm, B. Gutmann, C. O. Kappe, ChemSusChem 2013, 6, 978-982.

adipic acid

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In Situ Generation of Diimide from Hydrazine and Oxygen - Transfer Hydrogenation of Olefins in Continuous Flow.
B. Pieber, S. T. Martinez, D. Cantillo, C. O. Kappe, Angew. Chem. Int. Ed. 2013, 52, 10241.

diimide
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A Three Step Continuous Flow Synthesis of the Biaryl Unit of the HIV Protease Inhibitor Atazanavir.
L. Dalla-Vechia, B. Reichart, T. N. Glasnov, L. S. M. Miranda, C. O. Kappe, R. O. M. A. de Souza,
Org. Biomol. Chem. 2013, 11, 6806.

Continuous Flow Synthesis of alpha-Haloketones – Essential Building Blocks of Antiretroviral Agents.
V. D. Pinho, B. Gutmann, L. S. M. Miranda, R. O. M. A. de Souza, C. O. Kappe,
J. Org. Chem. 2014, 79, in press.

atazanavir

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Continuous Flow Generation and Reactions of Anhydrous Diazomethane Using a Teflon AF-2400 Tube-in-Tube Reactor.
F. Mastronardi, B. Gutmann, C. O. Kappe,
Org. Lett. 2013, 16, 5590-5593.

Continuous Flow Synthesis of alpha-Haloketones – Essential Building Blocks of Antiretroviral Agents.
V. D. Pinho, B. Gutmann, L. S. M. Miranda, R. O. M. A. de Souza, C. O. Kappe,
J. Org. Chem. 2014, 79, 1555-1562




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A Scalable Procedure for Light Induced Benzylic Brominations in Continuous Flow.
D. Cantillo, O. de Frutos, J. A. Rincon, C. Mateos , C. O. Kappe,
J. Org. Chem. 2014, 79,223-229.

Continuous Flow alpha-Trifluoromethylation of Ketones by Metal Free Visible Light Photoredox Catalysis.
D. Cantillo, O. de Frutos, J. A. Rincon, C. Mateos , C. O. Kappe,
Org. Lett. 2013, 17, 5590-5593.




______________________________________________________________________________

Flash Carboxylation: Fast Lithiation - Carboxylation Sequence at Room Temperature in Continuous Flow.
B. Pieber, T. Glasnov, C. O. Kappe,
RSC Adv. 2014, 4, 13430-13433.




______________________________________________________________________________

Continuous Flow Synthesis of alpha-Haloketones – Essential Building Blocks of Antiretroviral Agents.
V. D. Pinho, B. Gutmann, L. S. M. Miranda, R. O. M. A. de Souza, C. O. Kappe,
J. Org. Chem. 2014, 79, 1555-1562.



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A Sequential Nitration/Hydrogenation Protocol for the Synthesis of Triaminophloroglucinol − Safe Generation and Use of an Explosive Intermediate under Continuous Flow Conditions
D. Cantillo, M. Damm, D. Dallinger, M. Bauser, M. Berger, C. O. Kappe
Org. Process Res. Develop. 2014, 18, in press.



______________________________________________________________________________
Shifting Chemical Equilibria in Flow – Efficient Decarbonylation Chemistry Driven by Annular Flow Regimes.
B. Gutmann, P. Elsner, T. Glasnov, D. M. Roberge, C. O. Kappe,
Angew. Chem. Int. Ed. 2014, 53, in press.



______________________________________________________________________________
Microwave Chemistry
The group has a 15 year experience in microwave chemistry in a variety of different disciplines, including organic synthesis, solid-phase peptide chemistry, the generation of nanomaterials, and proteomics applications. Since 1999 more than 150 publications including several review articles and books were published. We are able to perform microwave-assisted reactions from the microliter scale using microtiter plates up to the liter scale employing suitable large scale equipment.
Of particular interest over the past years was the investigation of so-called microwave effects where we have published extensively. For recent reviews on this topic see the following references and follow this link:
Microwave Effects in Organic Synthesis – Myth or Reality?
C. O. Kappe, B. Pieber, D. Dallinger, Angew. Chem. Int. Ed. 2013, 52, 1088-1094

Unraveling the Mysteries of Microwave Chemistry Using Silicon Carbide Reactor Technology.
C.O. Kappe, Acc. Chem. Res. 2013, 46, 1579-1585.

How to Measure Reaction Temperature in Microwave-heated Transformations.
C.O. Kappe, Chem. Sov. Rev. 2013, 42, 4977-4990.


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Microwave-Assisted Organic Synthesis in Near-Critical Water at 300 <sup>o</sup>C. A Proof-of-Concept Study
Microwave-Assisted Organic Synthesis in Near-Critical Water at 300 oC. A Proof-of-Concept Study
Jennifer M. Kremsner and C. Oliver Kappe
Karl-Franzens-University Graz

more »


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 http://www.ch.ic.ac.uk/ectoc/echet96/papers/016/
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 C. Oliver Kappe of the Karl-Franzens-University, Graz has found (J. Org. Chem. 2007, 72, 4440. DOI: 10.1021/jo070408f) that thioamides such as 14 couple smoothly under Pd catalysis with areneboronic acids, even more rapidly than the usually reactive alkenyl bromide. Hans-Dieter Arndt of the Universität Dortmund has developed (J. Org. Chem. 2007, 72, 4205. DOI: 10.1021/jo0703505) a hetero Diels-Alder approach to pyridines, based on the addition of alkynes such as 16 to the diene 17. Richmond Sarpong of the University of California, Berkeley, has devised (Org. Lett. 2007, 9, 2167. DOI: 10.1021/ol070658i) an elegant Pt-catalyzed rearrangement of alkynyl aziridines such as 19, giving, after sulfinate elimination, pyridines such as 20.

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Communication to me from a great scientist...cut paste below
 cokappe  to ....................ANTHONY MELVIN CRASTO

On fri 26 dec 2014



Dear Anthony,

a very pleasant surprise……Keep up the good work.

Regards, oliver


Prof. C. Oliver Kappe
Institute of Chemistry, University of Graz
Heinrichstrasse 28, A-8010 Graz, Austria
Tel.: +43 316 3805352. Fax: +43 316 3809840

Editor-in-Chief, Journal of Flow Chemistry




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GRAZ AUSTRIA
 
 

 




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