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Thursday, 22 January 2015

Dr Charlotte Wiles

Charlotte Wiles

Dr Charlotte Wiles  

Chief Executive Officer, Chemtrix BV, 
Dr. Charlotte Wiles has been actively researching within the area of micro reactor technology for ten years, starting with a PhD entitled `Micro reactors in organic chemistry`, which she obtained from The University of Hull in 2003.
In the past decade she has authored many scientific papers and review articles, recently co-authoring a book on the subject 'Micro reaction technology in organic synthesis'.
More recently, she has tailored her experience to the development and evaluation of commercially available continuous flow reactors, systems and peripheral equipment.


Chief Executive Officer: Dr Charlotte Wiles

Starting her research in the area of continuous flow synthesis in 2000, Charlotte obtained her PhD in 2003 entitled “Microreactors in organic synthesis”.

This was followed by 5 years of Post-Doctoral research into the rapidly developing field of continuous flow synthesis, specifically in the area of heterogeneous catalysis for small molecule synthesis.

In 2008 Charlotte joined Chemtrix BV as a Senior Chemist where she worked on the commercialisation of lab-scale micro reactor apparatus.

 In 2010 she was promoted to Chief Technology Officer within Chemtrix BV where she continues to research and develop continuous flow systems and solutions for industrial partners; with more recent developments focusing on industrial flow reactors, suited towards the development of flexible tonne-scale production plants.

Over the course of her research career, Charlotte has published more than 55 peer-reviewed articles, several book chapters and in 2011 published a book “Micro reaction technology in organic synthesis”.



CPhI India, Dec2015, MUMBAI, INDIA.

With Dr Charlotte Wiles, CEO, CHEMTRIX BV , Cambridge, UK at CPhI India, Dec2015, MUMBAI, INDIA......At Pi-inc (Process Intensification Experts LLP) stall, hall 5 H47,

At Pi-inc (Process Intensification Experts LLP) stall, hall 5 H47, seen is Mr Vijay Kirpalani with Charlotte wiles


Chemtrix BV.


Chemtrix BV.
– Present
In the 5 years since the start of Chemtrix BV the Team has developed a complete product portfolio of Flow Chemistry Equipment and Services, setting up strategic partnerships with ESK Ceramics (Germany) and DSM Fine Chemicals (Austria) and it is with this strong background that Chemtrix BV will continue to grow under the Management of Dr Charlotte Wiles.

Being part of the Company since its start in 2008, and CTO of Chemtrix BV since 2010, I will continue to use my 13 years experience in the area of Flow Chemistry to grow the Company in the new role of CEO, effective as of the 7th of August 2013.

Chief Technology Officer

Chemtrix BV
(5 years 5 months)
As the Chief Technology Officer at Chemtrix BV I am involved in the design and evaluation of equipment developed to enable users to successfully implement continuous flow reactor technology into their synthetic processes from both a research and production perspective

Post Docotoral Research Associate

The University of Hull
(4 years 7 months)
Continuous flow organic synthesis using glass based micro reactors

With Dr (Ms) Charlote wiles, CEO chemtrix , at IISER-PUNE, Pune INDIA on 27 Aug 2016 for Flow Chemistry Symposium + Workshop ...

IGCW | Home
Dr. Charlotte Wiles Chief Executive Officer,

 Image result for university of hull


Hull University
(5 years)
Development of continuous flow reactions in custom fabricated glass micro reactors - in conjunction with Industrial partners.


John Smeaton Community High School

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Chemtrix BV is located on 2 sites. In Hull (United Kingdom) Dr Charlotte Wiles (CEO) is running the Chemtrix R&D laboratory within facilities of The University of Hull. All the other activities (Management, Engineering, Product Development, Quality Assurance, Marketing & Sales) are located at the headquarters based on the Chemelot (www.chemelot.com) site in Geleen.
Chemtrix BV, Chemical Department is located at The University of Hull

Cottingham Road
Hull HU6 7RX
United Kingdom
T: +44 (0) 1482 466 459
F: +44 (0) 1482 466 410
Chemtrix BV, Chemical Department

Company Profile

DSM and Chemtrix sign collaboration agreement in Continuous Flow Chemistry
Launch of Plantrix Industrial Flow Reactor
ESK Ceramics acquires minorty share in Chemtrix B.V.
Launch of KiloFlow®
Launch of Labtrix® Start
Launch of Labtrix® and Plantrix®
Launch of Chemtrix USA
July 2008
Entrance of new investors
April 2008
Chemtrix BV established in Geleen
Chemtrix LTD established in Hull
Start negotiations between Lionix BV and The University of Hull about co-operation
Change over to high quality chips purchased from Lionix BV (www.lionixbv.nl) in Enschede (the Netherlands)
Dr Paul Watts starts MRT Research at the University of Hull (www.hull.ac.uk) using in-house fabricated reactors

 Monograph on Microreaction Technology
Thumbnail image of graphical abstract
CRC Press, Boca Raton, 2011. 453 pp., hardcover, £ 89.00.—ISBN 978-1439824719

Micro Reaction Technology in Organic Synthesis. By Charlotte Wiles and Paul Watts.




Publications Authored By Charlotte Wiles

Against a backdrop of a struggling economic and regulatory climate, pharmaceutical companies have recently been forced to develop new ways to provide more efficient technology to meet the demands of a competitive drug industry. This issue, coupled with an increase in patent legislation and a rising generics market, makes these themes common issues in the growth of drug development. As a consequence, the importance of process chemistry and scale-up has never been more under the spotlight.
ChemSusChem 2012 Feb 8;5(2):332-8. Epub 2011 Dec 8.
Chemtrix BV, Burgemeester Lemmensstraat 358, 6163JT Geleen, The Netherlands. c.wiles@chemtrix.com
In light of the growing interest in the use of rare earth metal triflates as water-tolerant Lewis acid catalysts, we embarked upon the development of a solid-supported gallium triflate (PS-Ga(OTf)(2) ) derivative as a means of increasing the cleanliness and cost effectiveness of using these increasingly expensive catalytic materials in synthetic processes. Having previously highlighted the advantages associated with coupling solid-supported catalysis and the emerging area of micro-reaction technology, we screened PS-Ga(OTf)(2) for activity towards the ketonic Strecker reaction, in which the target α-aminonitriles were obtained in higher yield and purity compared to reactions reported in literature, in which the analogous homogeneous catalyst was used.

Beilstein J Org Chem
Beilstein J Org Chem 2011 4;7:1360-71. Epub 2011 Oct 4.
Chemtrix BV, Burgemeester Lemmensstraat 358, 6163 JT, Geleen, The Netherlands.
Whilst microwave heating has been widely demonstrated as a synthetically useful tool for rapid reaction screening, a microwave-absorbing solvent is often required in order to achieve efficient reactant heating. In comparison, microreactors can be readily heated and pressurised in order to "super-heat" the reaction mixture, meaning that microwave-transparent solvents can also be employed. To demonstrate the advantages associated with microreaction technology a series of S(N)Ar reactions were performed under continuous flow by following previously developed microwave protocols as a starting point for the investigation.
Chem. Commun. (Camb.)
Chem Commun (Camb) 2011 Jun 29;47(23):6512-35. Epub 2011 Mar 29.
Chemtrix BV, Burgemeester Lemmensstraat 358, 6163 JT, Geleen, The Netherlands. c.wiles@chemtrix.com
It is the intention of this review to provide the reader with a survey of the current literature pertaining to the use of micro reactors in synthetic chemistry; recent advances are briefly discussed, with references provided to assist with further reading on this rapidly growing research topic.

J. Am. Chem. Soc.
J Am Chem Soc 2011 Mar 22;133(10):3601-8. Epub 2011 Feb 22.
WestCHEM, Department of Pure and Applied Chemistry and CPACT, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.
A novel method has been devised to derive kinetic information about reactions in microfluidic systems. Advantages have been demonstrated over conventional procedures for a Knoevenagel condensation reaction in terms of the time required to obtain the data (fivefold reduction) and the efficient use of reagents (tenfold reduction). The procedure is based on a step change from a low (e.

Future Med Chem
Future Med Chem 2009 Dec;1(9):1593-612
Chemtrix BV, Burgemeester Lemmensstraat 358, 6163JT Geleen, The Netherlands. c.wiles@chemtrix.com
Medicinal chemists are under increasing pressure, not only to identify lead compounds and optimize them into clinical candidates, but also to produce materials in sufficient quantities for subsequent investigation. With this in mind, continuous-flow methodology presents an opportunity to reduce the time taken to, first, identify the compound and, second, scale the process for evaluation and, where necessary, production. It is therefore the aim of this review to provide the reader with an insight into the advantages associated with the use of continuous-flow chemistry through the use of strategically selected literature examples.

Beilstein J Org Chem
Beilstein J Org Chem 2009 2;5:27. Epub 2009 Jun 2.
Department of Chemistry, The University of Hull, Cottingham Road, Hull, HU6 7RX, UK. c.wiles@chemtrix.com
We report the use of an immobilised form of Candida antarctica lipase B, Novozym((R)) 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidant hydrogen peroxide (100 volumes). Initial investigations focussed on the lipase-mediated oxidation of 1-methylcyclohexene, with the optimised reaction conditions subsequently employed for the epoxidation of an array of aromatic and aliphatic alkenes in 97.6 to 99.

A (+)-gamma-lactamase was precipitated, cross-linked and the resulting solid crushed prior to immobilisation within a capillary column microreactor. The microreactor was subsequently used to study enzyme stability, activity, kinetics and substrate specificity. The thermophilic (+)-gamma-lactamase retained 100% of its initial activity at the assay temperature, 80 degrees C, for 6 h and retained 52% activity after 10 h, indicating the advantage of immobilisation.

Sol-gel nanoprobes, also known as Photonic Explorer for Bioanalysis with Biologically Localised Embedding (PEBBLE), capable of performing in-vitro intracellular monitoring of reactive oxygen species have been developed using a modified form of 5(6)-carboxyfluorescein diacetate. A sol-gel matrix was selected for the design of the probes as it is photostable, optically transparent and chemically inert, and to minimise leaching of the dye from the porous matrix it was covalently immobilised to silica nanoparticles (15 nm). Using this approach,
Chem. Commun. (Camb.)
Chem Commun (Camb) 2007 Dec(46):4928-30
The University of Hull, Hull, UK. c.wiles@chem.hull.ac.uk
We present herein a micro reactor set-up that enables parallel syntheses to be performed under electroosmotic flow conditions.
Expert Opin Drug Discov
Expert Opin Drug Discov 2007 Nov;2(11):1487-503
University of Hull, Department of Chemistry, Cottingham Road, Hull, HU6 7RX, UK +44 (0)1482 466410 ; P.Watts@hull.ac.uk.
Owing to the competitive nature of the pharmaceutical industry, researchers involved in lead compound generation are under continued pressure to identify and develop promising programmes of research in order to secure intellectual property. The potential of a compound for therapeutic development depends not only on structural complexity, but also on the identification of synthetic strategies that will enable the compound to be prepared on the desired scale. One approach that is of present interest to the pharmaceutical industry is the use of continuous flow reactors, with the flexible nature of the technology being particularly attractive as it bridges the changes in scale required between the initial identification of a target compound and its subsequent production.

Chem. Commun. (Camb.)
Chem Commun (Camb) 2007 Mar 11(9):966-8. Epub 2006 Dec 11.
Department of Chemistry, Faculty of Science and the Environment, The University of Hull, Cottingham Road, Hull HU6 7RX, UK.
By employing a series of reactions we demonstrate the use of electroosmotic flow as a continuous pumping mechanism suitable for semi-preparative scale synthesis, affording an array of small organic compounds, of analytical purity, with yields ranging from 0.57-1.71 g h(-1)
Org. Biomol. Chem.
Org Biomol Chem 2007 Mar 30;5(5):727-32. Epub 2007 Jan 30.
Department of Chemistry, The University of Hull, Cottingham Road, Hull, UK. P.Watts@hull.ac.uk
This review focuses on the use of micro reactors as tools in synthetic organic chemistry, aiming to highlight the many advantages associated with their use, in particular their ability to synthesise products in high yield, purity and, where relevant, selectivity.
Lab Chip
Lab Chip 2007 Mar 8;7(3):322-30. Epub 2007 Jan 8.
Department of Chemistry, University of Hull, Hull, HU6 7RX, UK.
Micro reaction technology offers a safe, controllable and information rich technique suitable for the long-term production of pharmaceutical agents and fine chemicals. To date however, few of the syntheses performed using this technology have addressed the problems associated with product purification. With this in mind, we report herein the incorporation of multiple supported reagents into EOF-based miniaturized flow reactors for the two-step synthesis of analytically pure compounds.
Chem. Commun. (Camb.)
Chem Commun (Camb) 2007 Feb 12(5):443-67. Epub 2006 Oct 12.
The University of Hull, Cottingham Road, Hull, UKHU6 7RX. P.Watts@hull.ac.uk
Although in its infancy, the field of micro reaction technology is growing rapidly, with many research groups investigating the practical advantages associated with reaction miniaturisation. With this in mind, the following Feature Article aims to provide an overview of the progress made in the past decade, paying particular attention to the field of synthetic organic chemistry.

Lab Chip
Lab Chip 2004 Jun 17;4(3):171-3. Epub 2004 Mar 17.
Department of Chemistry, The University of Hull, Cottingham Road, Hull, UK HU6 7RX.
A simple technique for the diastereoselective alkylation of a metal stabilised enolate is demonstrated within a pressure-driven micro reactor whereby enhanced diastereoselectivities were obtained compared to batch. 
Lab Chip
Lab Chip 2002 Aug 17;2(3):141-4. Epub 2002 Jun 17.
Department of Chemistry, University of Hull, Cottingham Road, Hull, UKHU6 7RX.
We demonstrate that peptides derived from alpha-amino acids may be prepared in a micro reactor. The peptides were prepared in 20 min with quantitative conversion, compared to batch reactions which require prolonged reaction times. We illustrate that by using dilute reagent concentrations and short reaction times, less racemisation is observed in micro reactions than in bulk reactions.

Chem. Commun. (Camb.)
Chem Commun (Camb) 2002 May(10):1034-5
Department of Chemistry, Faculty of Science and the Environment, University of Hull, Cottingham Road, Hull, UK HU6 7RX.
We demonstrate a simple method for the regioselective preparation of 1,3-diketones within a micro reactor from silyl enol ethers where the products are free from both competing O-acylation and diacylation products.

Lab Chip
Lab Chip 2002 May 19;2(2):62-4. Epub 2002 Apr 19.
Department of Chemistry, Faculty of Science and the Environment, University of Hull, Cottingham Road, Hull, UKHU6 7RX.
We demonstrate the formation of a series of diketone enolates and their subsequent reaction with alpha,beta-unsaturated carbonyl compounds in order to prepare a variety of Michael adducts. In all cases, the conversions observed within a micro reactor were greater than those obtained in batch.Read More...http://www.pubfacts.com/author/Charlotte+Wileshttp://www.pubfacts.com/author/Charlotte+Wiles


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