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DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
Since her appointment, MGF has established the first solid-state group in Hull and obtained funding from EPSRC, Leverhulme Trust and Yorkshire Forward. MGF is one of only few chemists in the UK to have extensive expertise in the use of advanced techniques for the preparation and characterization of oxide, mixed-anion and non-oxide compounds. She was involved in a project on the preparation of silicon nitride based nanoporous ceramics, which are tested by a range of industrial partners for application in gas sensors and as catalysts. She has reported highly novel mixed-anion compounds and the discovery and improvement via chemical manipulation of negative magnetoresistance in a family of sulphides. In this area, she has a long-standing fruitful collaboration with Drs Maignan and Hardy at CRISMAT Laboratoire, Caen. Other national and international collaborations include the University of Birmingham and with Prof G. Calestani at the University of Parma (Italy). She has given numerous invited presentations at conferences and at academic institutions and has written invited reviews in the field. She has published 61 papers to date.
Specialties: INORGANIC SOLID STATE CHEMISTRY: PREPARATION AND CHARACTERISATION OF NON-OXIDE MATERIALS
X-RAY DIFFRACTION
A novel and simple preparation of amine-modified γ-Fe2O3 nanoparticles is described. The presence of amine groups on the surface, instead of hydroxyl groups, will allow conjugation of biologically active molecules to the iron oxide nanoparticles without the need for a size increasing silica shell. Furthermore, the outer amine-layer increases the temperature of the γ-Fe2O3 to α-Fe2O3 structural...more
Doping of Inorganic Materials in Microreactors - Preparation of Zn doped Fe3O4 Nanoparticles
Lab on a Chip, 2015, 15, 3154 - 3162
Microreactor systems are now used more and more for the continuous production of metal nanoparticles and metal oxide nanoparticles owing to the controllability of the particle size, an important property in many applications. Here, for the first time, we used microreactors to prepare metal oxide nanoparticles with controlled and varying metal stoichiometry. We prepared and characterised Zn-...more
Chief Executive Officer, Chemtrix
BV,
Dr.
Charlotte Wiles has been actively researching within the area of micro
reactor technology for ten years, starting with a PhD entitled `Micro
reactors in organic chemistry`, which she obtained from The University
of Hull in 2003.
In the past decade she has authored many scientific
papers and review articles, recently co-authoring a book on the subject
'Micro reaction technology in organic synthesis'.
More recently, she has
tailored her experience to the development and evaluation of
commercially available continuous flow reactors, systems and peripheral
equipment.
WITH DR ANTHONY CRASTO, Dr VIJAY KRIPALANI
EXTREME RIGHT .....DR CHARLOTTE WILES. ....AT SELECTBIO FLOW CHEMISTRY CONFERENCE IN MUMBAI, INDIA, 22 JAN 2015
Starting her research in the area of continuous flow synthesis in 2000,
Charlotte obtained her PhD in 2003 entitled “Microreactors in organic
synthesis”.
This was followed by 5 years of Post-Doctoral research into
the rapidly developing field of continuous flow synthesis, specifically
in the area of heterogeneous catalysis for small molecule synthesis.
In
2008 Charlotte joined Chemtrix BV as a Senior Chemist where she worked
on the commercialisation of lab-scale micro reactor apparatus.
In 2010
she was promoted to Chief Technology Officer within Chemtrix BV where
she continues to research and develop continuous flow systems and
solutions for industrial partners; with more recent developments
focusing on industrial flow reactors, suited towards the development of
flexible tonne-scale production plants.
Over the course of her research
career, Charlotte has published more than 55 peer-reviewed articles,
several book chapters and in 2011 published a book “Micro reaction
technology in organic synthesis”.
With Dr Charlotte Wiles, CEO, CHEMTRIX BV , Cambridge, UK at CPhI India, Dec2015, MUMBAI, INDIA......At Pi-inc (Process Intensification Experts LLP) stall, hall 5 H47,
At Pi-inc (Process Intensification Experts LLP) stall, hall 5 H47, seen is Mr Vijay Kirpalani with Charlotte wiles —
Experience
CEO
Chemtrix BV.
– Present
In
the 5 years since the start of Chemtrix BV the Team has developed a
complete product portfolio of Flow Chemistry Equipment and Services,
setting up strategic partnerships with ESK Ceramics (Germany) and DSM
Fine Chemicals (Austria) and it is with this strong background that
Chemtrix BV will continue to grow under the Management of Dr Charlotte
Wiles.
Being part of the Company since its start in 2008, and CTO of Chemtrix
BV since 2010, I will continue to use my 13 years experience in the area
of Flow Chemistry to grow the Company in the new role of CEO, effective
as of the 7th of August 2013.
Chief Technology Officer
Chemtrix BV
– (5 years 5 months)
As
the Chief Technology Officer at Chemtrix BV I am involved in the design
and evaluation of equipment developed to enable users to successfully
implement continuous flow reactor technology into their synthetic
processes from both a research and production perspective
Post Docotoral Research Associate
The University of Hull
– (4 years 7 months)
Continuous flow organic synthesis using glass based micro reactors www2.hull.ac.uk/
With Dr (Ms) Charlote wiles, CEO chemtrix , at IISER-PUNE, Pune INDIA on 27 Aug 2016 for Flow Chemistry Symposium + Workshop ...
Organisation
Chemtrix
BV is located on 2 sites. In Hull (United Kingdom) Dr Charlotte Wiles
(CEO) is running the Chemtrix R&D laboratory within facilities of
The University of Hull. All the other activities (Management,
Engineering, Product Development, Quality Assurance, Marketing &
Sales) are located at the headquarters based on the Chemelot (www.chemelot.com) site in Geleen.
Chemtrix BV, Chemical Department is located at The University of Hull
Against a backdrop of a struggling economic and regulatory
climate, pharmaceutical companies have recently been forced to develop
new ways to provide more efficient technology to meet the demands of a
competitive drug industry. This issue, coupled with an increase in
patent legislation and a rising generics market, makes these themes
common issues in the growth of drug development. As a consequence, the
importance of process chemistry and scale-up has never been more under
the spotlight.
Chemtrix BV, Burgemeester Lemmensstraat 358, 6163JT Geleen, The Netherlands. c.wiles@chemtrix.com
In light of the growing interest in the use of rare earth
metal triflates as water-tolerant Lewis acid catalysts, we embarked upon
the development of a solid-supported gallium triflate (PS-Ga(OTf)(2) )
derivative as a means of increasing the cleanliness and cost
effectiveness of using these increasingly expensive catalytic materials
in synthetic processes. Having previously highlighted the advantages
associated with coupling solid-supported catalysis and the emerging area
of micro-reaction technology, we screened PS-Ga(OTf)(2) for activity
towards the ketonic Strecker reaction, in which the target
α-aminonitriles were obtained in higher yield and purity compared to
reactions reported in literature, in which the analogous homogeneous
catalyst was used.
Chemtrix BV, Burgemeester Lemmensstraat 358, 6163 JT, Geleen, The Netherlands.
Whilst microwave heating has been widely demonstrated as a
synthetically useful tool for rapid reaction screening, a
microwave-absorbing solvent is often required in order to achieve
efficient reactant heating. In comparison, microreactors can be readily
heated and pressurised in order to "super-heat" the reaction mixture,
meaning that microwave-transparent solvents can also be employed. To
demonstrate the advantages associated with microreaction technology a
series of S(N)Ar reactions were performed under continuous flow by
following previously developed microwave protocols as a starting point
for the investigation.
It is the intention of this review to provide the reader
with a survey of the current literature pertaining to the use of micro
reactors in synthetic chemistry; recent advances are briefly discussed,
with references provided to assist with further reading on this rapidly
growing research topic.
WestCHEM,
Department of Pure and Applied Chemistry and CPACT, University of
Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.
A novel method has been devised to derive kinetic
information about reactions in microfluidic systems. Advantages have
been demonstrated over conventional procedures for a Knoevenagel
condensation reaction in terms of the time required to obtain the data
(fivefold reduction) and the efficient use of reagents (tenfold
reduction). The procedure is based on a step change from a low (e.
Chemtrix BV, Burgemeester Lemmensstraat 358, 6163JT Geleen, The Netherlands. c.wiles@chemtrix.com
Medicinal chemists are under increasing pressure, not only
to identify lead compounds and optimize them into clinical candidates,
but also to produce materials in sufficient quantities for subsequent
investigation. With this in mind, continuous-flow methodology presents
an opportunity to reduce the time taken to, first, identify the compound
and, second, scale the process for evaluation and, where necessary,
production. It is therefore the aim of this review to provide the reader
with an insight into the advantages associated with the use of
continuous-flow chemistry through the use of strategically selected
literature examples.
Department of Chemistry, The University of Hull, Cottingham Road, Hull, HU6 7RX, UK. c.wiles@chemtrix.com
We report the use of an immobilised form of Candida
antarctica lipase B, Novozym((R)) 435, in a preliminary investigation
into the development of a continuous flow reactor capable of performing
the chemo-enzymatic oxidation of alkenes in high yield and purity,
utilising the commercially available oxidant hydrogen peroxide (100
volumes). Initial investigations focussed on the lipase-mediated
oxidation of 1-methylcyclohexene, with the optimised reaction conditions
subsequently employed for the epoxidation of an array of aromatic and
aliphatic alkenes in 97.6 to 99.
A (+)-gamma-lactamase was precipitated, cross-linked and
the resulting solid crushed prior to immobilisation within a capillary
column microreactor. The microreactor was subsequently used to study
enzyme stability, activity, kinetics and substrate specificity. The
thermophilic (+)-gamma-lactamase retained 100% of its initial activity
at the assay temperature, 80 degrees C, for 6 h and retained 52%
activity after 10 h, indicating the advantage of immobilisation.
Department of Chemistry, The University of Hull, Cottingham Road, Hull, UK HU6 7RX.
Sol-gel nanoprobes, also known as Photonic Explorer for
Bioanalysis with Biologically Localised Embedding (PEBBLE), capable of
performing in-vitro intracellular monitoring of reactive oxygen species
have been developed using a modified form of 5(6)-carboxyfluorescein
diacetate. A sol-gel matrix was selected for the design of the probes as
it is photostable, optically transparent and chemically inert, and to
minimise leaching of the dye from the porous matrix it was covalently
immobilised to silica nanoparticles (15 nm). Using this approach,
University of Hull, Department of Chemistry, Cottingham Road, Hull, HU6 7RX, UK +44 (0)1482 466410 ; P.Watts@hull.ac.uk.
Owing to the competitive nature of the pharmaceutical
industry, researchers involved in lead compound generation are under
continued pressure to identify and develop promising programmes of
research in order to secure intellectual property. The potential of a
compound for therapeutic development depends not only on structural
complexity, but also on the identification of synthetic strategies that
will enable the compound to be prepared on the desired scale. One
approach that is of present interest to the pharmaceutical industry is
the use of continuous flow reactors, with the flexible nature of the
technology being particularly attractive as it bridges the changes in
scale required between the initial identification of a target compound
and its subsequent production.
Department of Chemistry, Faculty of Science and the Environment, The University of Hull, Cottingham Road, Hull HU6 7RX, UK.
By employing a series of reactions we demonstrate the use
of electroosmotic flow as a continuous pumping mechanism suitable for
semi-preparative scale synthesis, affording an array of small organic
compounds, of analytical purity, with yields ranging from 0.57-1.71 g
h(-1)
Department of Chemistry, The University of Hull, Cottingham Road, Hull, UK. P.Watts@hull.ac.uk
This review focuses on the use of micro reactors as tools
in synthetic organic chemistry, aiming to highlight the many advantages
associated with their use, in particular their ability to synthesise
products in high yield, purity and, where relevant, selectivity.
Department of Chemistry, University of Hull, Hull, HU6 7RX, UK.
Micro reaction technology offers a safe, controllable and
information rich technique suitable for the long-term production of
pharmaceutical agents and fine chemicals. To date however, few of the
syntheses performed using this technology have addressed the problems
associated with product purification. With this in mind, we report
herein the incorporation of multiple supported reagents into EOF-based
miniaturized flow reactors for the two-step synthesis of analytically
pure compounds.
The University of Hull, Cottingham Road, Hull, UKHU6 7RX. P.Watts@hull.ac.uk
Although in its infancy, the field of micro reaction
technology is growing rapidly, with many research groups investigating
the practical advantages associated with reaction miniaturisation. With
this in mind, the following Feature Article aims to provide an overview
of the progress made in the past decade, paying particular attention to
the field of synthetic organic chemistry.
Department of Chemistry, The University of Hull, Cottingham Road, Hull, UK HU6 7RX.
A simple technique for the diastereoselective alkylation of
a metal stabilised enolate is demonstrated within a pressure-driven
micro reactor whereby enhanced diastereoselectivities were obtained
compared to batch.
Department of Chemistry, University of Hull, Cottingham Road, Hull, UKHU6 7RX.
We demonstrate that peptides derived from alpha-amino acids
may be prepared in a micro reactor. The peptides were prepared in 20
min with quantitative conversion, compared to batch reactions which
require prolonged reaction times. We illustrate that by using dilute
reagent concentrations and short reaction times, less racemisation is
observed in micro reactions than in bulk reactions.
Department of Chemistry, Faculty of Science and the Environment, University of Hull, Cottingham Road, Hull, UK HU6 7RX.
We demonstrate a simple method for the regioselective
preparation of 1,3-diketones within a micro reactor from silyl enol
ethers where the products are free from both competing O-acylation and
diacylation products.
Department of Chemistry, Faculty of Science and the Environment, University of Hull, Cottingham Road, Hull, UKHU6 7RX.
We demonstrate the formation of a series of diketone
enolates and their subsequent reaction with alpha,beta-unsaturated
carbonyl compounds in order to prepare a variety of Michael adducts. In
all cases, the conversions observed within a micro reactor were greater
than those obtained in batch.Read More...http://www.pubfacts.com/author/Charlotte+Wileshttp://www.pubfacts.com/author/Charlotte+Wiles
.
UNIV OF HULL
UNIV OF HULL 
