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Saturday, 21 November 2015

Aaron C. Sather


 Aaron C. Sather
 Buchwald Group
 Aaron is a NIH Postdoctoral Fellow at MIT in the research laboratory of Prof. Stephen Buchwald.

Contact Information

t: 617-253-8893

Aaron C. Sather earned his BSc at the University of Oregon, working with Prof. Darren W. Johnson on arsenic remediation and anion recognition. He graduated cum laude with the distinction of departmental honors. He then moved to The Scripps Research Institute to study molecular recognition under the guidance of Prof. Julius Rebek, Jr., where he was both a Baxter Fellow and an ARCS Fellow. Presently, Aaron is a NIH Postdoctoral Fellow at MIT in the research laboratory of Prof. Stephen Buchwald.

Lab Positions Start Date Fellowships and Awards Previous Institutions
Postdoctoral Researcher 2013 NIH Postdoctoral Fellowship Ph.D: The Scripps Research Institute, La Jolla, CA
Advisor: Prof. Julius Rebek, Jr.
Thesis: Molecular Encapsulation and the Selective Recognition of the Uranyl Ion
B.Sc: University of Oregon, Eugene, OR
Advisor: Prof. Darren W. Johnson
Thesis: Anion Recognition and Arsenic Remediation


NIH post-doctoral fellow

Massachusetts Institute of Technology (MIT)
– Present (2 years 3 months)cambridge, massachusetts

Graduate Stutent

Julius Rebek Jr. Laboratory
– Present (7 years)The Scripps Research Institute

Undergraduate Research Assistant

Darren W. Johnson Laboratory
(3 years)University of Oregon


Diastereoselectivity in the Self-Assembly of As2L2Cl2 Macrocycles is Directed by the As-π Interaction(Link)

Inorganic Chemistry
September 20, 2007
The As−π interaction, in conjunction with reversible As−thiolate bond formation, is used to direct the self-assembly of dinuclear As2L2Cl2 (L = a dithiolate) macrocycles that exist as equilibrium mixtures of both syn and anti diastereomers. The diastereomeric excess of these self-assembly reactions is controlled in a predictable manner by prudent choice of different achiral, isomeric ligands. A...more

Solution Phase Measurement of Both Weak σ and C−H···X− Hydrogen Bonding Interactions in Synthetic Anion Receptors(Link)

Journal of the American Chemical Society
July 29, 2008
A series of tripodal receptors preorganize electron-deficient aromatic rings to bind halides in organic solvents using weak σ anion-to-arene interactions or C−H···X− hydrogen bonds. 1H NMR spectroscopy proves to be a powerful technique for quantifying binding in solution and determining the interaction motifs, even in cases of weak binding.

Anion Binding Induces Helicity in a Hydrogen Bonding Receptor: Crystal Structure of a 2,6-Bis(anilinoethynyl)pyrdinium Chloride(Link)

Crystal Growth and Design
September 2, 2009
The synthesis and solid-state of 2,6-bis(anilinoethynyl)pyridine amide 1 is presented. Neutral receptor 1 forms a polymeric chain through hydrogen bonds and π stacking in the solid state. Upon protonation, receptor 1 undergoes significant conformational rearrangement to hydrogen bond to Cl−, forming a helix (H1+Cl−). This rare example of anion-induced helicity is detailed in the solid state and...more

Synthesis of Novel Aryl-1,2-oxaxoles from Ortho-hydroxyaryloximes(Link)

Tetrahedron Letters
November 11, 2009
The reaction of ortho-hydroxyaryloximes with p-toluenesulfonyl chloride in the presence of an amine base efficiently generates the corresponding aryl-1,2-oxazole. Investigations revealed that solvent polarity greatly affected the rate of the reaction with faster rates observed in more polar solvents. The reaction proceeds to completion in only a few minutes in acetonitrile at room temperature, and...more

A Synthetic Receptor for Hydrogen-Bonding to Fluorines of Trifluoroborates(Link)

Chemical Communications
September 4, 2009
A tripodal receptor featuring three inwardly-directed hydrogen-bond donors binds covalently bound fluorine atoms of trifluoroborates through hydrogen-bonding.

Autocatalysis and Organocatalysis with Kemp’s Triacid Compounds(Link)

August 20, 2010
Synthetic structures capable of autocatalysis based on molecular recognition – self-replication – were introduced nearly 20 years ago. These systems involved neither informational oligomers such as nucleic acids nor conditions that are generally regarded as prebiotic, but they revealed how self-complementary molecules could act as templates for their own formation and helped define the structure...more

Reactivity of N-nitrosoamides in Confined Spaces(Link)

Tetrahedron Letters
April 27, 2011
The thermal rearrangement of several N-nitrosoamides was studied by 1H NMR in the context of reversible encapsulation. The N-nitrosoamide guests were isolated from the bulk solvent in a hydrogen-bonded dimeric host capsule which prevented their rearrangement. The guests appear to be preserved in their ground state conformations by the pressure exerted by the host. The conformations of the free and...more

Selective Recognition and Extraction of the Uranyl Ion(Link)

Journal of the American Chemical Society
September 14, 2010
A tripodal receptor capable of extracting uranyl ion from aqueous solutions has been developed. At a uranyl concentration of 400 ppm, the developed ligand extracts 59% of the uranyl ion into the organic phase. The new receptor features three carboxylates that converge on the uranyl ion through bidentate interactions. Solution studies reveal slow exchange of the carboxylates on the NMR time scale....more

Supramolecular Architecture with a Cavitand – Capsule Chimera(Link)

Angewandte Chemie International Edition
January 18, 2011
Molecule-within-molecule complexes are widely used in supramolecular chemistry for studies of molecular recognition and catalysis. Self-assembled hosts isolate their guests from the bulk media and reveal unique molecular behaviors. An assembly that features well-differentiated and non-interacting binding sites stabilized through hydrogen-bonding interactions is described.

A Light Controlled Cavitand Wall Regulates Guest Binding(Link)

Chemical Communications
September 14, 2010
Here we report a cavitand with a photochemical switch as one of the container walls. The azo-arene switch undergoes photoisomerization when subjected to UV light producing a self-fulfilled cavitand. This process is thermally and photochemically reversible. The reported cavitand binds small molecules and these guests can be ejected from the cavitand through this photochemical process.

Design, Synthesis and Characterization of Self-Assembled As2L3 and Sb2L3 Cryptands(Link)

Dalton Transactions
July 28, 2011
The syntheses and X-ray crystal structures of six new self-assembled supramolecular As and Sb-containing cryptands are described. Analysis in the context of previously reported As2L3 and Sb2L3 cryptands reveals that small differences in ligand geometries result in significant differences in the helicity of the complexes and the stereochemistry of the metal coordination within the assembled...more

A Deep Cavitand with a Fluorescent Wall Functions as an Ion Sensor(Link)

Organic Letters
September 13, 2011
The synthesis and characterization of a deep cavitand bearing a fluorescent benzoquinoxaline wall is reported. Noncovalent host–guest recognition events are exploited to sense small charged molecules including acetylcholine. The cavitand also exhibits an anion dependent change in fluorescence that is used to differentiate halide ions in solution.

Switchable Catalysis with a Light Responsive Cavitand(Link)

Angewandte Chemie International Edition
September 8, 2011
A cavitand with an azobenzene wall adopts an introverted shape when irradiated with UV light. This conformation has been characterized in solution and the solid state and is used to control guest binding. By incorporating an organocatalyst guest, the rate of the Knoevenagel condensation is controlled with light.

Synthesis of Fused Indazole Ring Systems and Application to Nigeglanine Hydrobromide(Link)

Organic Letters
March 2, 2012
The single-step synthesis of fused tricyclic pyridazino[1,2-a]indazolium ring systems is described. Structural details revealed by crystallography explain the unexpected reactivity. The method is applied to the gram scale synthesis of nigeglanine hydrobromide.

Uranyl Ion Coordination with Rigid Aromatic Carboxylates and Structural Characterization of their Complexes(Link)

Chemical Communications
May 31, 2013
Uranyl complexes of rigid aromatic carboxylates were synthesized and their solid-state structures characterized by X-ray crystallography. The new ligands create cavities lined with endohedral functions to encapsulate the uranyl ion.

Pnictogen-Directed Synthesis of Discrete Disulfide Macrocycles(Link)

Chemical Communications
June 5, 2013
Cyclic disulfide macrocycles were rapidly synthesized cleanly and selectively from rigid dithiols via oxidation with iodine when activated by pnictogen additives (As and Sb). Macrocycles were confirmed by 1H-NMR spectrscopy and X-ray crystallography. A p-xylyl-based disulfide trimer and tetramer crystallized in hollow, stacked columns stabilized by intermolecular, sulfur…sulfur close contacts.


The Scripps Research Institute

Doctor of Philosophy (PhD), Chemistry

University of Oregon

Bachelor of Applied Science (B.A.Sc.), Chemistry

With Aaliyah and Lupita Sather.

Cambridge, Massachusetts

 Map of cambridge ma








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