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Monday, 2 November 2015

Dr. Alice Varghese


Dr. Alice Varghese

Dr. Alice Varghese

Asst. Professor in Pharmaceutical Analysis at NMIMS, School of pharmacy and technology
LINKS
https://in.linkedin.com/pub/dr-alice-varghese/16/627/306
https://www.facebook.com/alice.varghese.982
https://www.researchgate.net/profile/Alice_Varghese

Official Email Id
alice.varghese@nmims.edu
Office Phone No.
+91-022-42332000
alice

Summary

• University Lecturer involved in teaching subjects in pharmacy such as pharmaceutical analysis, medicinal chemistry, organic chemistry, spectroscopy and sophisticated instrumentation • Researcher in the field of drug metabolism and pharmacokinetics, drug-drug interactions, drug herb interactions • Handled two government aided research projects • Over 10 research papers in peer reviewed journals • Two awards for best presentation at scientific conferences • Expertise in handling sophisticated instruments like HPLC, GC, LC-MS, LC-MS/MS etc. • Expertise Drug-drug and drug herb interaction studies – In vitro CYP inhibition and induction, P-gp interaction, In vivo PK-PD studies,Tissue distribution studies using mass spectroscopic techniques, Reaction phenotyping studies of new chemical entities and active herbal constituents, Drug metabolism and metabolite profiling of new chemical entities and active herbal constituents

Experience




Asst. Professor in Pharmaceutical Chemistry

NMIMS, School of pharmacy and technology
July 2009 – Present (6 years 5 months)NMIMS, Vile Parle (W)
Involved in teaching pharmaceutical analysis, pharmaceutical chemistry and allied subjects for undergraduate and post graduate students
Teaching Pharmaceutical analysis, pharm. chemistry, medicinal chemistry, NMR, Mass. RESEARCH PROJECTS HANDLED • Co-investigator of an Indian government funded project by Department of biotechnology (DBT) entitled “Investigations on the Cytochrome P450 (CYP450) interaction potential of some medicinal plants” (Rs. 38.74 lakhs/ approximately 57000 USD) • Co-investigator of an Indian government funded project by Department of biotechnology (DBT) entitled “Discovery of novel KCNQ2/Q3 potassium channel activators as potential therapeutics for epilepsy” (Rs. 21 lakhs/ approximately 35000 USD)



Research Associate

Piramal LifeSciences Limited
December 2006 – July 2009 (2 years 8 months)
AREAS OF EXPERTISE • In vitro CYP (Cytochrome P450) inhibition studies using microsomes, S9 fractions etc. • HTS cytochrome P450 inhibition study (Protocol by Invitrogen, VIVID) and standardized CYP inhibition using Human Liver Microsomes (HLM) • Enzyme induction studies assessed by enzyme activity • In vivo pharmacokinetic studies • Analytical method development and validation on HPLC and LC-MS/MS • Bioanalytical method development and validation in various biological matrices like blood, plasma, urine, feaces, tissues etc. • Drug-Plasma protein binding assay by ultrafiltration /equilibrium dialysis/ ultracentrifugation • Standardized permeability studies using Parallel Artificial Membrame Permeability Assay (PAMPA) • In vitro Cross-species metabolite profiling • Drug tissue distribution studies in rat and mice using mass spectroscopy • In vivo metabolite identification studies using mass spectroscopy • Hands on experience in handling HPTLC, HPLC, GC, LC-MS, LC-MS/MS • Drug – drug interaction studies of medicinal plants which includes IC50 determination, Ki value determination, mechanism of inhibition and time dependent inhibition of CYP enzymes • In vitro glucuronidation (Phase II studies) in liver microsomes • Preparation of herbal extracts and standardizing extracts using HPTLC and HPLC



student

Bombay College of Pharmacy
1999 – 2006 (7 years)
B.Pharm & M. Pharm
   

Education




University of Mumbai

M.Pharm, Science
1997 – 2006
 

Publications




Investigation of CYP3A4 and CYP2D6 Interactions of Withania somnifera and Centella asiatica in Human Liver Microsomes; Phytotherapy research

Wiley Intersciences
January 2015



In-vitro & in-vivo evaluation of CYP1A interaction potential of Terminalia arjuna bark

Indian Journal of Pharmaceutical Sciences
March 2014



Development and validation of HPTLC method for Simultaneous Determination of Quercetin & Kaempferol In leaves of two chemotypes of Centella asiatica

Journal of Planar Chromatography - Modern TLC
2012
   

Experience

8.5 years (Industry – 3.5 years, Academics- 5 years)
Worked as a Quality Assurance Trainee at Inga Laboratories Pvt. Ltd., for a year. Post M.Pharm worked as a Research Associate in Dept. of Drug metabolism and Pharmacokinetics (DMPK) at Piramal Life Sciences Ltd. (December 06 – July 09). Areas of expertise involve In vitro CYP (Cytochrome P450) inhibition studies using microsomes, S9 fractions etc. In vivo pharmacokinetic studies, Analytical method development and validation on HPLC and LC-MS/MS, Bioanalytical method development and validation in various biological matrices like blood, plasma, urine, feaces, tissues etc., Drug – drug interaction studies of medicinal plants which includes IC50 determination, Ki value determination, mechanism of inhibition and time dependent inhibition of CYP enzymes. Hands on experience in handling HPTLC, HPLC, GC, LC-MS, LC-MS/MS

Interest Areas

  • Drug-drug and drug herb interaction studies – In vitro CYP inhibition and induction, P-gp interaction
  • In vivo pharmacokinetic-pharmacodynamic studies
  • Tissue distribution studies using mass spectroscopic techniques
  • Reaction phenotyping studies of new chemical entities and active herbal constituents
  • Drug metabolism and metabolite profiling of new chemical entities and active herbal constituents

Research

  • Publications – 12 (National – 06, International – 06)
  • Presentations- 07 (National- 07)
  • Government funded projects – 02
    • Co-investigator of a Department of biotechnology (DBT) project entitled “Investigations on the Cytochrome P450 (CYP450) interaction potential of some medicinal plants” (Rs. 38.74 lakhs)
    • Co-investigator of a Department of biotechnology (DBT) entitled “Discovery of novel KCNQ2/Q3 potassium channel activators as potential therapeutics for epilepsy” (Rs. 21 lakhs)

Conferences/Workshops/Seminars attended07

Academic activities

She has guided more than 15 no. of M.Pharm. students for their research projects.

 

Awards

  • Received prize for best poster at the 5th International Symposium on Drug Metabolism & Pharmacokinetics (DMPK) held at NIPER, Mohali in March 2013
  • Received 2nd prize for an oral presentation at Manshodan – December 2012, a research colloquium at Mithibai college, Mumbai
  • Qualified in Graduate Aptitude Test in Engineering (GATE- 2004), conducted by Indian Institute of Technology (IIT), Delhi, with score of 99.57 percentile, All India Rank - 36

Professional Memberships

Member of Association of Pharmacy Teachers of India (APTI).

Recent Publications

  1. Alice Varghese, Nancy Pandita & R.S. Gaud, “In-vitro & in-vivo evaluation of CYP1A interaction potential of Terminalia arjuna bark” Indian Journal of Pharmaceutical Sciences; March – April 2014; 41 – 50
  2. Alice Varghese, Nancy Pandita & R.S. Gaud, “A novel, sensitive, bioanalytical method for estimation of amlodipine besylate in rat plasma using flourescence detection by RP HPLC”, International Journal of Pharmaceutical Sciences and Research; July 2014; Vol. 5(7): 2813 - 2820.
  3. Joshi C, Savai J, Varghese A, Pandita N, Development and validation of HPTLC method for Simultaneous Determination of Quercetin & Kaempferol In leaves of two chemotypes of Centella asiatica; Journal of Planar Chromatography - Modern TLC; 25 (2012) 5, 433–438


 
 DMPK conference 2013 - NIPER, Mohali




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