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Tuesday, 17 May 2016

Michal Shavit

Michal Shavit.

Michal Shavit

Research Scientist at On Target Chemistry Israel

On Target Chemistry official opening


Research Scientist

On Target Chemistry from the Recipharm group
 – Present (8 months)Ness Ziona, Israel

Postdoctoral Researcher

Technion - Israel Institute of Technology
 –  (8 months)Haifa

Research Assistant

Columbia University
 –  (1 year 1 month)


Technion - Israel Institute of Technology

Doctor of Philosophy (PhD), Chemistry

The Hebrew University

Master of Science (MSc), Chmistry

The Hebrew University of Jerusalem

Bachelor’s Degree, Chmistry


Active cytotoxic reagents based on non-metallocene non-diketonato well-defined C2-symmetrical titanium complexes of tetradentate bis(phenolato) ligands(Link)

J. Am. Chem. Soc.
September 18, 2007
A new family of non-Cp-based non-diketonato-based C2-symmetrical octahedral Ti(IV) complexes of dianionic diamine bis(phenolato) ligands, which are conveniently obtained as single isomers in quantitative yields, leads to appreciable cytotoxicity against colon and ovarian cells with a non-transferrin-dependent cell penetration mechanism. The ligand structural features including steric demands,...more

Structural characterization of dinuclear Ti(IV) complexes of rigid tetradentate dianionic diamine bis(phenolato) ligands; effect of steric bulk on coordination features(Link)

Journal of Organometallic Chemistry
October 4, 2008
A small difference in diamine bis(phenolato) ligands, namely an additional single methylene unit, directs formation of dinuclear Ti(IV) complexes rather than mononuclear ones as characterized by X-ray crystallography. Varying steric bulk of the ligand affects the coordination number in the dinuclear complexes and the ligand to metal ratio. A ligand with reduced steric bulk leads to a L2Ti2(OiPr)4...more

Antitumor Reactivity of Non-Metallocene Titanium Complexes of Oxygen-Based Ligands: is Ligand Lability Essential?(Link)

J. Biol. Inorg. Chem.
July 2007
In our attempt to define the parameters affecting anticancer activity of titanium complexes and to assess the role of hydrolytic stability, titanium compounds of oxygen-based ligands were studied. A homoleptic complex of hydroxyamino-1,3,5-triazine ligands was prepared and its hydrolysis was investigated by UV–vis spectroscopy at biologically relevant pH and temperature conditions based on its...more
4 authors
  • Michal Shavit
    Michal Shavit
    Research Scientist at On Target Chemistry Israel
  • Dani Peri
    Dani Peri
    Materials and Inorganic Chemist
  • No photo
    Artem Melman
  • No photo
    Edit Y. Tshuva

Preparation and X-Ray Structures of Ti(IV) Complexes of Bis(carboxylato) Ligands; Formation of Mono-, Di-, Tetra- and Hexanuclear Complexes With or Without OR and μ-O Ligands

Eur. J. Inorg. Chem.
2 authors

Synthesis, Characterization, Cytotoxicity, and Hydrolytic Behavior of C2 and C1-Symmetrical Ti(IV) Complexes of Tetradentate Diamine Bis(Phenolato) Ligands: A New Class of Antitumor Agents

Chem. Eur. J

TiIV Complexes of Branched Diamine Bis(phenolato) Ligands: Hydrolysis and Cytotoxicity

Eur. J. Inorg. Chem.

Increased Selectivity toward Cytoplasmic versus Mitochondrial Ribosome Confers Improved Efficiency of Synthetic Aminoglycosides in Fixing Damaged Genes: A Strategy for Treatment of Genetic Diseases Caused by Nonsense Mutations

Journal of Medicinal Chemistry

Design of Novel Aminoglycoside Derivatives with Enhanced Suppression of Diseases-Causing Nonsense Mutations

ACS Medicinal Chemistry Letters
February 8, 2016


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