DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair,With death on the horizon, This will not stop me, Gods call only..........
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contributio

Friday, 6 May 2016

Renee Bouley


Renee Bouley





I am an interdisciplinary PhD candidate that headed an antibiotic discovery project resulting in a patent application and 1 first-author publication in Journal of the American Chemical Society. I have been trained in organic chemistry, microbiology, biochemistry, pharmacology, and x-ray crystallography and co-authored 4 publications including 1 publication in Nature Chemical Biology. Additionally, I have been awarded 2 individual fellowships during my graduate career from the American Chemical Society and National Institutes of Health.
Conference Poster 2014
Conference Poster 2014
Resume 2015
Resume 2015
Nature Chemical Biology cover November 2015
Nature Chemical Biology cover November 2015


University of Notre Dame

PhD, Organic Chemistry
1 first-author publication, 3 contributing author publications, 1 contributing author on patent application
(Open)5 honors and awards

Grand Valley State University

Bachelors of Science, Chemistry
1 first author publication
Activities and Societies: Chemistry Club, Tutored, Deans List
(Open)1 honor or award


Graduate Student

University of Notre Dame
– Present (6 years)
Synthesized 40 analogs and determined a structure-activity relationship.
Determined metabolic stability and plasma stability of synthetic compounds
Evaluated synthetic compounds in mouse models of infection
Identified the biological target and mechanism of action of synthetic compounds by protein activity assays, protein-ligand crystal complexes, and macromolecular synthesis assays
(Open)1 honor or award

Research Internship

Consejo Superior de Investigaciones Científicas
(4 months)Madrid, Spain
Grew crystals of membrane protein and performed co-crystallization studies with ligands
Measured protein crystals at the Swiss Light Source in Zurich, Switzerland
Analyzed the diffraction data by molecular replacement

Teaching Assistant

University of Notre Dame
(1 year 5 months)
Fall 2010:
Supervised and instructed students majoring in chemistry in organic chemistry techniques
Graded weekly lab reports and course exams
Spring 2011 & Fall 2011:
Led weekly discussion sections in which students worked on problem sets
Gave short lectures on the background information needed to complete each problem set
Graded weekly problem sets and course exams

Student Learning Assistance Facilitator

Grand Valley State University
(10 months)
Led weekly discussions in which students worked on problems sets I prepared
Gave lectures that reviewed relevant course material

Chemistry Tutor

Grand Valley State University
(1 year 8 months)
Met with individual students and small groups (up to 4) of students on a weekly basis to provide help with homework or material they found difficult to understand.

Research Assistant

Grand Valley State University
(2 years 5 months)
Synthesized a polyaniline matrix and incorporated onto electrodes
Measured polyaniline matrices by electrochemical impedance spectroscopy (EIS)
Measured resistance and capacitance of a redox protein, cytochrome c, by EIS

Analytical Chemistry Intern

(4 months)
Evaluated anti-inflammatory activity of botanical extracts using a MMP-9 protein activity assay
Evaluated botanical extracts for effects on melanonin production using a mouse tryosinase protein activity assay
Quantified solubility of active ingredients in botanical extracts using HPLC

Honors & Awards

Baxter Young Investigator Award

Baxter Healthcare
Second Tier Awardee for Baxter Young Investigator Award


Ruth L. Kirschstein NRSA Individual Predoctoral Fellowship (F31)

National Institute of Allergy and Infectious Disease


American Chemical Society Division of Medicinal Chemistry Predoctoral Fellowship

American Chemical Society Division of Medicinal Chemistry

Chemistry-Biochemistry-Biology Interface Fellowship

University of Notre Dame
Program at Notre Dame funded by the NIH to provide training to students at the interface of chemistry and the biological sciences.

Chemistry-Biology-Biochemistry Interface Symposium Oral Presentation Competition Winner

University of Notre Dame

Chemistry-Biology-Biochemistry Interface Symposium Poster Competition Winner

University of Notre Dame

Undergraduate Award in Inorganic Chemistry

Grand Valley State University


Discovery of Antibiotic (E)-3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one(Link)

Journal of the American Chemical Society
January 28, 2015
Highlighted in ACS Chem. Biol. 2015, 10, 639
Recommended by Faculty of 1000

Synergistic, collaterally-sensitive β-lactam combinations suppress resistance in MRSA.(Link)

Nature Chemical Biology
September 14, 2015
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most prevalent multidrug-resistant pathogens worldwide, exhibiting increasing resistance to the latest antibiotic therapies. Here we show that the triple β-lactam combination meropenem-piperacillin-tazobactam (ME/PI/TZ) acts synergistically and is bactericidal against MRSA subspecies N315 and 72 other clinical MRSA isolates in vitro...more

Electrochemical Protein Redox Activity under Extreme Martian Conditions(Link)

Electrochemistry Society Transactions
May 29, 2009

Renee Bouley selected to receive prestigious ACS Predoctoral Fellowship

Published: July 02, 2013

Renee Bouley
Renee Bouley, a third year graduate student in the Department of Chemistry and Biochemistry, has been selected to receive a prestigious American Chemical Society (ACS) Division of Medicinal Chemistry Predoctoral Fellowship.  Bouley is one of only four recipients chosen for the 2013-2014 cycle.
This award supports doctoral candidates working in the area of medicinal chemistry who have demonstrated superior achievements as graduate students and who show potential for future work as independent investigators. These fellowships have been awarded annually since 1991 and include one year stipend support and an invitation to present the fellow’s research results at a special awards session at the ACS National Meeting.
Bouley’s work, conducted under the advisement of Shahriar Mobashery, Navari Family Professor in Life Sciences, and Mayland Chang, Research Professor and Director of the Chemistry-Biochemistry-Biology Interface (CBBI) Program, centers around the discovery of a new class of antibiotics that are selective against staphylococcal species of bacteria, including hard-to-treat methicillin-resistant Staphylococcus aureus (MRSA).  She has already identified a class of compounds that has in vitro activity against bacteria and demonstrated efficacy in mice. Bouley spent three months in 2012 in the laboratory of Prof. Juan Hermoso at Consejo Superior de Investigaciones Cientificas in Madrid, Spain, where she solved the crystal structure of the lead compound in complex with its target protein. Her studies have shown an unprecedented mechanism of action that opens opportunities for clinical resurrection of β-lactam antibiotics in combination with the new antibiotics. Bouley’s work during her fellowship tenure will explore structural analogs of these compounds with the goal of optimizing their potency in vivo and improving their drug-like properties.
Bouley is already the recipient of a National Institutes of Health Ruth L. Kirschstein National Research Service Award – CBBI (Chemistry-Biochemistry-Biology Interface) Program, a CBBI Research Internship Award, and an American Heart Association Predoctoral Fellowship (declined)………..https://www.linkedin.com/in/renee-bouley-43243215
University of Notre Dame.

Research experience

  • Aug 2010–
    Research Assistant
    University of Notre Dame · Department of Chemistry and Biochemistry · Shahriar Mobashery
    United States · South Bend
  • May 2009–
    Aug 2009
    Research Assistant
    Amway · Analytical Services
  • Jan 2008–
    May 2010
    Research Assistant
    Grand Valley State University · Department of Chemistry


  • Aug 2010–
    Dec 2015
    University of Notre Dame
    Chemistry · PhD
    South Bend
  • Aug 2006–
    May 2010
    Grand Valley State University
    Chemistry · BS
    USA · Grand Rapids

Awards & achievements

  • Jan 2015
    Award: Ruth L. Kirschstein NRSA Individual Predoctoral Fellowship
  • Aug 2013
    Award: ACS Medicinal Chemistry Predoctoral Fellowship
  • Aug 2013
    Award: Chemistry-Biochemistry-Biology Interface Fellowship
  • Aug 2012
    Award: Chemistry-Biochemistry-Biology Interface Fellowship


  • Languages
  • Scientific Societies
    American Chemistry Society (ACS)
    American Association for the Advancement of Science (AAAS)


No comments:

Post a Comment