Faiza Al-Kharafi

Professor Faiza M. Al-KharafiDepartment of Chemistry
Kuwait University
State of Kuwait
Tel: 00965- 4811188 Ext. 7453
Email : chesc@kuc01.kuniv.edu.kw

Faiza Al-Kharafi (Arabic: فايزة الخرافي‎ Fāyzah al-Kharāfī; born 1946) is a Kuwaiti chemist and academic. She was the president ofKuwait University from 1993 to 2002 and was the first woman to head a major university in the Middle East.^[1] She is the vice president of the World Academy of Sciences.

Faiza Mohammed Al-Kharafi
Born	1946 (age 68–69) Kuwait
Fields	Electrochemistry, corrosion engineering
Alma mater	Ain Shams University Kuwait University

Early life and education

Faiza Al-Kharafi was born to a wealthy family in Kuwait in 1946. She attended Al Merkab High School. She received her BSc from Ain Shams University in Cairo in 1967. She then attended Kuwait University where she founded the Corrosion and Electrochemistry Research Laboratory. She received her master's in 1972 and her PhD in 1975.^[2]

Career

Al-Kharafi worked in Kuwait University's Department of Chemistry from 1975 to 1981. In 1984 she became chair of the department and served as Dean of the Faculty of Science from 1986 to 1989.^[2] She became a professor of chemistry at Kuwait University in 1987.^[3] On 5 July 1993, Emir Jaber Al-Ahmad Al-Jaber Al-Sabah issued a decree appointing Al-Kharafi as rector of the University,^[4] and she became the first woman to head a major university in the Middle East.^[1] She served as president from 1993 to 2002 where she oversaw a staff of 1,500.

Al-Kharafi has studied the impact of corrosion on engine cooling systems, distillation units for crude oil, and high temperature geothermal brines. As an electrochemist, she has studied the electrochemical behavior of aluminum, copper, platinum, niobium, vanadium, cadmium, brass, cobalt, and low carbon steel.^[5] She collaborated on the discovery of a class of molybdenum-based catalysts that improve gasoline octane without benzene by-products.^[6]

She joined the Board of the United Nations University in 1998.^[7] Following the passage of women's suffrage in Kuwait in 2005, she said "[w]hen we have political rights, we can express our opinion and vote for the correct person... This gives us the chance to express our ideas."^[1] In 2006, she helped to found the American Bilingual School in Kuwait. She is the vice president of The World Academy of Sciences. She is a board member of the Kuwait Foundation for the Advancement Sciences.

Works

• Al-Kharafi, Faiza (1983). Al Saratan Aw Al Khelyat Al Moutamarida [Cancer or Rebellious Cells].
• Al-Kharafi, Faiza (1986). Al Hareb Al Kimaeya [Chemical War].
• Abdullah, Aboubakr M.; Al-Kharafi, Faiza M.; Ateya, Badr G. (May 2006). "Intergranular corrosion of copper in the presence of benzotriazole". Scripta Materialia 54 (9): 1673–1677. doi:10.1016/j.scriptamat.2006.01.014.
• Makhseed, Saad; Al-Kharafi, Faiza; Samuel, Jacob; Ateya, Badr (25 April 2009). "Catalytic oxidation of sulphide ions using a novel microporous cobalt phthalocyanine network polymer in aqueous solution". Catalysis Communications 10 (9): 1284–1287. doi:10.1016/j.catcom.2009.01.034.

Awards and honours

Forbes magazine named her as one of "The 100 Most Powerful Women – Women To Watch In The Middle East" in 2005.^[1] She received the Kuwait Prize in Applied Sciences in 2006. The Council for Gulf Relations named her Top Gulf Woman of the Year in 2008.^[8] In 2011 she was the recipient of the L'Oréal-UNESCO Award for Women in Science for her work on corrosion.^[9]

Personal life

Al-Kharafi is married to Ali Mohammed Thanian Al-Ghanim and has five sons and ten grandchildren. Of her sons, Marzouq Al-Ghanim is the current speaker of Kuwait National Assembly. She spends her Summers at Lake Geneva, Switzerland. Her brothers are Jassem Al-Kharafi, former speaker of the Kuwaiti National Assembly, and the late Nasser Al-Kharafi. She shares in the family fortune from M. A. Kharafi & Sons.^[2][8]

References

1. ^ Jump up to:^a b c d "Middle Eastern Women To Watch". Forbes. 26 July 2005.
2. ^ Jump up to:^a b c "Fayza Al Khorafi". Who's Who Amongst Arab Women. Retrieved 20 June 2013.
3. Jump up^ O'Shea, Maria (1999). Kuwait (2nd ed.). New York: Marshall Cavendish Corp. p. 61. ISBN 978-0-7614-0871-0.
4. Jump up^ "This day of Kuwait's history". Kuwait News Agency. 5 July 2009.
5. Jump up^ "Faiza al-Kharafi". Kuwait–MIT Center. Retrieved 20 June 2013.
6. Jump up^ "Faiza Al-Kharafi (Αφρική και Αραβικές Χώρες)". Eleftherotypia. 3 March 2011.
7. Jump up^ "This day in Kuwait's history". Kuwait News Agency. 1 March 2008.
8. ^ Jump up to:^a b Farag, Talaat I. (July 2008). "Dr. Faiza Al-Khorafi, PhD". The Ambassadors Online Magazine.
9. "Outstanding women scientists to receive 2011 L’ORÉAL-UNESCO Awards (3 March) and Fellowships (2 March)". UNESCO. 25 February 2011.

Further reading

• "Kuwait University leader wants students who can adapt to change". Dallas Morning News. Reuters. 11 December 1993.
• "Kuwait Educator Sees a Need to Adapt College Curriculum to Changing World". Chicago Sun-Times. Reuters. 11 January 1994.
• Bollag, Burton. "A female president, the Arab world's first, guides the restoration of Kuwait U." The Chronicle of Higher Education 40.24 (1994): A45. Biography in Context. Web. 20 June 2013.

External links

• Video of Faiza al-Kharafi
• فيديو النقاش الذي دار بين د. فايزة الخرافي ود. رولا دشتي في مؤتمر البدون

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Ram Awatar Maurya

Visible-light photoredox catalysis: direct synthesis of fused [small beta]-carbolines through an oxidation/[3 + 2] cycloaddition/oxidative aromatization reaction cascade in batch and flow microreactors

Org. Chem. Front., 2015, 2,1308-1312
DOI: 10.1039/C5QO00207A, Research Article

D. Chandrasekhar, Satheesh Borra, Jeevak Sopanrao Kapure, Ghule Shailendra Shivaji, Gannoju Srinivasulu, Ram Awatar Maurya
Fused [small beta]-carbolines were synthesized via a visible light photoredox catalyzed oxidation/[3 + 2] cycloaddition/oxidative aromatization reaction cascade in batch and flow microreactors.

http://pubs.rsc.org/en/Content/ArticleLanding/2015/QO/C5QO00207A#!divAbstract

Fused β-carbolines were synthesized via a visible light photoredox catalyzed oxidation/[3 + 2] cycloaddition/oxidative aromatization reaction cascade in batch and flow microreactors.

Several structurally diverse heterocyclic scaffolds were obtained in good yields by coupling of tetrahydro-β-carbolines with a variety of dipolarophiles under photoredox multiple C–C bond forming events.

The photoredox coupling of tetrahydro-β-carboline with 1,4-benzoquinone was significantly faster in continuous flow microreactors and the desired products were obtained in higher yields compared to batch reactors.

Synthetic procedures General experimental procedures for the synthesis of N-alkylated of tetrahydro-β-carbolines 1a-f: In a 25 mL round bottom flask, tryptoline (86 mg, 0.5 mmol), α-halo carbonyls (0.5 mmol), Et3N (50 mg, 0.5 mmol) and CH2Cl2 (5 mL) was taken and the reaction mixture was stirred at ambient temperature for 2 h. Next the reaction mixture was diluted with CH2Cl2 (15 mL) and washed with water. The organic layer was dried over anhydrous Na2SO4 and evaporated to yield a crude product which was purified by silica-gel column chromatography using ethyl acetate/hexane in increasing polarity to yield compounds 1a-f.

General experimental procedures for the visible light photoredox catalyzed coupling of Nalkylated of tetrahydro-β-carbolines 1a-f with dipolarophiles 2a-g under batch conditions: In a 25 mL round bottom flask, tetrahydro-β-carbolines 1a-f (0.1 mmol), dipolarophiles 2a-g (0.1 mmol), [Ru(bpy)3Cl2]·6H2O (0.5 mol%) and MeCN (5 mL) was taken. The reaction vessel was kept at a distance of 10 cm (approx.) from a visible light source (11W white LED bulb) and the reaction mixture was stirred in open air condition until the reaction was complete (TLC). Next the reaction mixture was concentrated to give a crude product which was purified Electronic Supplementary Material (ESI) for Organic Chemistry Frontiers. This journal is © the Partner Organisations 2015 by silica-gel column chromatography using ethyl acetate/hexane in increasing polarity to yield compounds 3a-n

General experimental procedures for the visible light photoredox catalyzed coupling of Nalkylated of tetrahydro-β-carbolines 1a with dipolarophiles 2a in flow microreactors: A solution of tetrahydro-β-carboline 1a (0.2 mmol) and dipolarophile 2a (0.2 mmol) in MeCN (5 mL) was kept in one syringe and the solutions of photocatalyst [Ru(bpy)3Cl2]·6H2O (0.001 mmol in 5 mL MeCN) and t-BuOOH (2 mmol in 2 mL MeCN) were taken in two separate syringes. All the three solutions were pumped via two syringe pumps and mixed on an Xjunction and flown through the capillary microreactor wrapped over a visible light source (11W white LED bulb). Under stable conditions, exactly 6 mL of the reaction mixture was collected, concentrated to yield a crude product which was purified by silica-gel column chromatography using ethyl acetate/hexane in increasing polarity to yield compounds 3a

     

D. Chandrasekhar,^a   Satheesh Borra,^a  Jeevak Sopanrao Kapure,^b   Ghule Shailendra Shivaji,^b  Gannoju Srinivasulu^b and   Ram Awatar Maurya*^ac  

*Corresponding authors

^aDivision of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India
E-mail: ramaurya@iict.res.in

^bNational Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad-500035, India

^cAcademy of Scientific and Innovative Research, New Delhi 110025, India

Org. Chem. Front., 2015,2, 1308-1312

DOI: 10.1039/C5QO00207A

Ram Awatar Maurya

PhD

INSPIRE FACULTY

Indian Institute of Chemical T..., Hyderabad · Medicinal Chemistry and Pharmacology Division (IICT)

RESEARCH EXPERIENCE

 Mar 2012–Jun 2012, PostDoc Position

• Pohang University of Science and Technology · Department of Chemical Engineering · Prof Dong Pyo Kim
  South Korea · Andong
• Sep 2009–Feb 2012, Post Doctoral Fellow
  Chungnam National University
  South Korea · Daejeon

 

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Zhiyong Wang

Zhiyong Wang

WANG Zhiyong（汪志勇）

Ph.D., University of Science and Technology of China (USTC) (1992); M.S., USTC (1989); B.S., Anhui Normal University (1982).


Professor of Chemistry
Department of Chemistry
School of Chemistry and Materials Science
University of Science and Technology of China
Hefei, Anhui 230026, P. R. China
Tel: 86-551-63603185
Fax: 86-551-63603185
E-mail: zwang3@ustc.edu.cn
Personal Homepage:
http://staff.ustc.edu.cn/~zwang3/default.htm

RESEARCH INTERESTS
Research in our group will focus on the general areas of reaction development and chemical synthesis. Our studies will be driven by the discovery of new and useful catalysts. By virtue of the developed organic reactions various organic ligands are synthesized and used as probes in biological progress. Brief summaries of three research directions illustrating these objectives are shown below:
1) The preparation of heterogeneous catalysts;
2) The theoretical calculation for the mechanism of organic reactions;
The application of organic ligands as probes or inhibitors to explore the molecular mechanism of HIV transcription.
PUBLICATIONS
http://www.researcherid.com/rid/F-7955-2010

WANG Zhiyong, Professor

Name: Zhiyong Wang（汪志勇） Born: June, 1962, Anhui, P. R. China Address: Department of Chemistry, University of Science and Technology of China, 230026 Hefei, P. R. China Tel: 86-551-63603185 Fax: 86-551-63603185 E-mail: zwang3@ustc.edu.cn EDUCATION AND RESEARCH EXPERIENCE 　1978-1982 B.S., Anhui Normal University 　1982-1986 Lecturer, South Anhui Agricultural College, China 　1986-1989 M.S., University of Science and Technology of China 　1989-1992 Ph.D., University of Science and Technology of China 　1992-1997 Lecturer, Associate Professor, University of Science and Technology of China 　1997-1999 Research Fellow, Tulane University & Brandeis University 　1999-Now Professor of Chemistry, University of Science and Technology of China RESEARCH INTERESTS 1) Organic reactions in aqueous media and development of synthetic methodology; 2) Supramolecular assembly under the control of organic ligands; 3) Drug design on the base of PCAF bromodomain. CURRENT RESEARCH PROJECTS 1) Organic reactions in water mediated by nano-metals and its application in asymmetric synthesis, National Natural Science Foundation (2004-2006) 2) Crystal Engineering under control of organic ligands, Foundation from Education Department of Anhui Province (2003-2005) REPRESENTATIVE PUBLICATIONS 1) C-F. Pan, M. Meze, S. Mujtaba, M. Muller, L. Zeng, J-M. Li, Z-Y. Wang,* M-M. Zhou* “Structure-Guided Optimization of Small Molecules Selectively Inhibiting HIV-1 Tat and PCAF Association” J. Med. Chem., 2007, 50, 2285 2) Y. Xie, Z-P. Yu, X-Y. Huang, Z-Y. Wang,* L-W. Niu, M-K. Teng, J. Li “Rational Design on the MOFs Constructed from modified Aromatic Amino Acids” Chem. Eur. J., 2007, 13, 9399 3) Z-H. Zhang, C-F. Pan, Z-Y. Wang* “Synthesis of chromanones: a novel palladium-catalyzed Wacker-type oxidative cyclization involving 1,5-hydride alkyl to palladium migration” Chem. Commun, 2007, 4686 4) Y. Xie, Y. Yan, H-H. Wu, G-P. Yong, Y. Cui, Z-Y. Wang*, L. Pan, J. Li “Homochiral Metal-organic Coordination Networks from L-Tryptophan” Inorg. Chim. Acta., 2007, 360,1669 5) Y. Xie, H-H. Wu, G-P. Yong,, Z-Y. Wang*, R. Fan , R-P. Li, G-Q. Pan, Y-C. Tian, L-S. Sheng, L. Pan, J. Li “Synthesis, Crystal Structure, Spectroscopic and Magnetic Properties of Two Cobalt Molecules Constructed from Histidine” J. Mol. Struct., 2007, 833, 88 6) Z-H. Zhang, Z-Y. Wang* “Diatomite-Supported Pd Nanoparticles: An Efficient Catalyst for Heck and Suzuki Reactions” J. Org. Chem., 2006, 71, 7485 7) Z-H. Zhang, Z-G. Zha, C-S. Gan, C-F. Pan, Y-Q. Zhou, Z-Y. Wang*, M-M. Zhou* “Catalysis and Regioselectivity of the Aqueous Heck Reaction by Pd(0) Nanoparticles under Ultrasonic Irradiation” J. Org. Chem., 2006, 71, 4339

Scheme 1
Control experiments.
The ubiquitous oxazoles have attracted more and more attention in both industrial and academic fields for decades. This interest arises from the fact that a variety of natural and synthetic compounds which contain the oxazole substructure exhibit significant biological activities and antiviral properties. Although various synthetic methodologies for synthesis of oxazols have been reported, the development of milder and more general procedure to access oxazoles is still desirable.

Initially, compound A, formed by the substitution reaction of 1a with 2a, which can be transformed following two pathways: (a) I⁺, generated by the oxidation of iodine, could oxidize A to radical intermediate B, which eliminates one molecular of CO₂ to generate radical C, which is further oxidized to imine Dor its isomer E. Subsequently, F is obtained by intramolecular nucleophilic addition of E. Finally, the desired product (3a) is given by deprotonation and oxidation of F; (b) G is formed from the oxidation of A. Then 3a is obtained through H, I, J, K following a process similar to path a.

Scheme 2
Plausible mechanism.

General procedure for the synthesis of polysubstituted oxazoles

1a (105.8 mg, 0.7 mmol), 2a (99.5 mg, 0.5 mmol), I₂ (50.8 mg, 0.2 mmol), DMA (2 mL) and TBHP (70% aqueous solution, 1 mmol) were placed in a tube (10 mL) and sealed with a thin film. Then the reaction mixture was stirred at 25°C for 4 h, heated up to 60°C and stirred at this temperature for another 4 h. After that, the resulting mixture was cooled to the room temperature, diluted with water, extracted with ethyl acetate. The organic phase was washed with saturation sodium chloride solution, dried and filtrated. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column separation (petroleum ether:ethyl acetate = 10:1) to give 3a(154.7 mg, 70%) as light yellow solid, mp = 70–72°C.
2,5-diphenyloxazole (3a) [1]
Synthesized according to typical procedure and purified by column chromatography (petroleum ether:ethyl acetate = 10:1) to give light yellow solid (154.7 mg, 70%), mp = 70-72 °C.

1H NMR (300 MHz, CDCl3): δ 8.12-8.09 (m, 2 H), 7.72-7.69 (m, 2 H), 7.50-7.40 (m, 6 H), 7.35-7.24 (m, 1 H).

13C NMR (75 MHz, CDCl3): δ 161.3, 151.4, 130.4, 129.0, 128.9, 128.5, 128.1, 127.6, 126.4, 124.3, 123.6.

HRMS (APCI-FTMS) m/z: [M + H]+ calcd for C15H12NO: 222.0913, Found: 222.0911.

The scope of the reaction. Standard conditions: 0.7 mmol of amino acids (1a-1h), 0.5 mmol of2a-2j, 0.1 mmol of I₂, 1 mmol of TBHP, 2 mL of DMA, were stirred at 25°C for 4 h then slowly raised to 60°C for 4 h. Catalysts amount and isolated yields were based on 2.

Metal-free synthesis of polysubstituted oxazoles via a decarboxylative cyclization from primary α-amino acids

Yunfeng Li, Fengfeng Guo, Zhenggen Zha and Zhiyong Wang^*

• *Corresponding author: Zhiyong Wang zwang3@ustc.edu.cn

Zhiyong Wang

Department of Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China

Sustainable Chemical Processes 2013, 1:8  doi:10.1186/2043-7129-1-8
The electronic version of this article is the complete one and can be found online at:http://www.sustainablechemicalprocesses.com/content/1/1/8

ADDITIONAL SPECTRAL DATA FROM NET

Hefei, Anhui China






 

 




////Metal-free,  Synthesis,  Oxazoles,  Oxidation,  Decarboxylative cyclization,  α-amino acids